Principles of Computational Cell Biology: From Protein Complexes to Cellular Networks

This first textbook of its kind provides an ideal introduction to computational cell biology for students of biology and bioinformatics. In particular the text focuses on a network–based approach to the study of cellular systems. Almost 30 carefully designed study exercises offer excellent support for those preparing for exams in these subjects, and help introduce the more technical aspects of the topic while keeping maths to a minimum.

Spis treści:
Preface.
1. Networks in Biological Cells.
2. Algorithms on Mathematical Graphs.
3. Protein–Protein Interaction Networks – Pairwise Connectivity.
4. Protein–Protein Interaction Networks – Structural Hierarchies.
5. Gene Regulatory Networks.
6. Metabolic Networks.
7. Kinetic Modeling of Cellular Processes.
8. Structures of Protein Complexes and Subcellular Structures.
9. Bimolecular Association and Binding.
10. Integrated Networks.
11. Outlook.
Index.

Nota biograficzna:
Volkhard Helms has been Professor of Bioinformatics in the Center of Bioinformatics, Saarland University since 2003, where he heads the bioinformatics department. He worked for his PhD in the European Molecular Biology Laboratory in Heidelberg and carried out post–doctoral work at UC San Diego. He then went on to lead a research group in theoretical biophysics at the Max Plank Institute of Biophysics in Frankfurt. In 2001 he was selected as an EMBO Young Investigator. His work focuses on computational approaches to the study of protein–protein interactions, transmembrane proteins, and cellular networks.

Okładka tylna:
This first textbook of its kind provides an ideal introduction to computational cell biology for students of biology and bioinformatics. In particular the text focuses on a network–based approach to the study of cellular systems. Almost 30 carefully designed study exercises offer excellent sup port for those preparing for exams in these subjects, and help introduce the more technical aspects of the topic while keeping maths to a minimum.