Protein Folding Handbook: 5 Volume Set

Based on the expertise of more than 60 research groups from around the globe, this unique reference integrates theoretical, biophysical, biochemical and medical aspects of protein folding for an in–depth coverage of the entire field.
Part I
Principles of Protein Stability
Kinetics of Protein Folding
Folding of Membrane Proteins
Structure and Dynamics of Unfolded States
Folding Intermediates
Molecular Dynamics Simulations of Protein Folding
Part II
In vivo Study of Protein Folding
Cellular Function and Regulation of Chaperones
Misfolded Proteins and Prions
Protein Folding Diseases
Design of Stable Proteins
Biotechnology of Protein Folding
Throughout the book, theoretical as well as practical aspects are addressed, including detailed protocols for key techniques in protein folding research.
The comprehensiveness and outstanding quality of the carefully selected contributions render this the ultimate resource for every scientist with an interest in protein folding.


Spis treści:
PART I: Principles of Protein Folding and Stability.
Spectroscopic techniques to study protein folding and stability.
Solvent effects on protein stability.
Analysis of protein folding kinetics, kinetic mechanisms, transition states.
Single molecule protein folding.
Dynamics of unfolded polypeptide chains.
Folding and stability of oligomeric proteins.
Folding of membrane proteins.
Molecular dynamics simulations of folding and unfolding.
Ab initio methods for protein structure prediction.
PART II: Protein Misfolding, Molecular Chaperones and Folding Catalysts.
Methods to study aggregate formation.
Amyloid diseases.
Polyglutamine repeat diseases.
Protein refolding technology.
Engineering protein stability.
Chaperone machines.
Folding of nascent polypeptides.
Protein assembly processes.

Nota biograficzna:
Johannes Buchner holds t he chair of Biotechnology at the Technical University of Munich (Germany). He studied Biology at the University of Regensburg and afterwards joined the group of Ira Pastan at the National Cancer Institute in Bethesda (United States). Returning to Germany, he took a up junior group leader position at Regensburg before becoming full professor at Munich in 1998.
Professor Buchner′s research is centered on the folding process of proteins and its efficiency in vitro and in vivo. To improve the efficiency of protein production, he has pioneered the biotechnological use of chaperones and holds several patents in this area of research.
Thomas Kiefhaber is Professor of Biophysical Chemistry at the Biozentrum, University of Basel (Switzerland). He studied Biology at the University of Regensburg (Germany) and, after completing his PhD in Biophysical Chemistry, spent two years as a post–doc with R. L. Baldwin at Stanford University. Since 1993 he is a member of the faculty of Basel University and was named professor for Biophysical Chemistry in 1999.
Professor Kiefhaber′s research is centered on the investigation of kinetics and mechanism of protein folding with biophysical methods.

Okładka tylna:
Based on the expertise of more than 60 research groups from around the globe, this unique reference integrates theoretical, biophysical, biochemical and medical aspects of protein folding for an in–depth coverage of the entire field.
Part I
Principles of Protein Stability
Kinetics of Protein Folding
Folding of Membrane Proteins
Structure and Dynamics of Unfolded States
Folding Intermediates
Molecular Dynamics Simulations of Protein Folding
Part II
In vivo Study of Protein Folding
Cellular Function and Regulation of Chaperones
Misfolded Proteins and Prions
Protein Folding Diseases
Design of Stable Proteins
Biotechnology of Protein Folding
Throughout the book, theoretical as well as practical aspects are addressed, including detailed protocols for key techniques in protein folding research.
The comprehensiveness and outstanding quality of the carefully selected contributions render this the ultimate resource for every scientist with an interest in protein folding.