Diabetes

This significant new publication provides a summary and overview of the most recent scientific advances in diabetes research, and highlights the role of these developments in advancing clinical practice. Diabetes is one of the major causes of morbidity and mortality in the developed world, and its prevalence elsewhere is on the increase. It affects in excess of 100 million people worldwide. Recent scientific advances have clarified our understanding of the causes and consequences of this devastating disease. These scientific developments are playing an increasingly important role in clinical practice and could well lead the way to the prevention of complications and even a cure for the disease. An international and authoritative team of authors draws together this knowledge and the most recent developments to provide an up-to-date account which will benefit researchers and clinicians.

Spis treści:
1. The regulation of insulin gene transcription
2. Molecular structure of insulin
3. Regulation of insulin secretion
4. Insulin receptors
5. The role of protein phosphorylation in insulin action
6. Glucose transport mechanisms
7. Glucose homeostasis
8. Epidemiology of insulin-dependent diabetes mellitus (IDDM)
9. Genetics of IDDM
10. Aetiology of Type 1 (insulin-dependent) diabetes
11. Epidemiology of NIDDM
12. Genetic basis of the aetiology of non-insulin-dependent diabetes (NIDD)
13. Islet amyloid polypeptide and amyloid in the islets of Langerhans
14. Primary insulin resistance
15. Epidemiology of the complications of diabetes
16. Macrovascular disease in diabetes
17. Diabetic neuropathy
18. Diabetic foot infections
19. Ocular complications of diabetes
20. Diabetic nephropathy
21. The personal, social and economic burden of diabetic complications
22. Mortality among persons with diabetes
23. Glycation and diabetic complications
24. The sorbitol pathway and diabetic complications
25. Proteinuria and diabetic complications
26. Pharmacologic approaches to NIDDM
27. Insulin and insulin analogues
28. Hypoglycaemia
29. Strategies for prevention of Type 1 (insulin-dependent) diabetes
30. Treatment of early diabetic renal disease
31. Pancreatic transplantation in humans with diabetes mellitus
32. Rational insulin management of IDDM
33. Rationale in the management of non-insulin-dependent diabetes mellitus (NIDDM)
34. Psychosocial aspects of diabetes care
Index.