The Biochemistry of Drug Metabolism: Volume 1: Principles, Redox Reactions, Hydrolyses

Understanding the biochemistry of drug metabolism is today one of the most critical aspects of new drug development to assure safe and efficacious medicines of the future. The present work provides an exemplary scientific basis for the biochemistry of drug metabolism upon which both experienced and newly initiated drug–metabolism scientists may depend. It documents the progresse and major advances in our understanding of drug metabolism in an encyclopedic, but very readable format. The figures in this volume represent a Powerpoint presentation to simulate a well–organized, comprehensive, and readily understandable series of slides as would be given in an oral presentation. the text provides the reader with the sound bites that the lectu4rers present to explicate the slides. But as an added bonus, the text contains all the thoroughly referenced citations to the discussion for further examination by the reader. I find the presentation technique to be delightful and expect that other readers will have the same experience.′ – Leslie Z. Benet
The present volume features the principles of drug metabolism, followed by the enzymes and reactions of oxidation, reduction, and hydrolysis. A continuation is in preparation.

Spis treści:
Part 1: Principles and Overview
1.1. Drugs and Xenobiotics
1.2. What Are Drug Disposition and Metabolism?
1.3. Where Does Drug Metabolism Occur?
1.4. Consequences of Drug Metabolism – An Overview
1.5. Drug Metabolism and Drug Discovery
Part 2: Redox Reactions and Their Enzymes
2.1. Cytochromes P450 (CYPs) and Flavin–Containing Monooxygenases (FMOs)
2.2. CYP–Catalyzed sp3–C–Oxidations
2.2. CYP–Catalyzed sp2–C– and sp–C–Oxidations
2.4. Oxidations of N– and S–Atoms Catalyzed by CYPs and/or FMOs
2.5. Other Reactions Catalyzed by CYPs
2.6. Other Oxidoreductases and Their Reactions
Part 3: Reactions of Hydrolysis and Their Enzymes
3.1. A Survey of Hydrolases
3.2. The Hydrolysis of Carboxylic Esters
3.3. Synthetic Reactions of Esterases
3.4. The Hydrolysis of Amides and Peptides
3.5. Hydrolytic Ring Opening
3.6. The Hydrolysis of Esters of Inorganic Acids
3.7. The Hydration of Epoxides
3.8. Miscellaneous Reactions

Okładka tylna:
Understanding the biochemistry of drug metabolism is today one of the most critical aspects of new drug development to assure safe and efficacious medicines of the future. The present work provides an exemplary scientific basis for the biochemistry of drug metabolism upon which both experienced and newly initiated drug–metabolism scientists may depend. It documents the progresse and major advances in our understanding of drug metabolism in an encyclopedic, but very readable format. The figures in this volume represent a Powerpoint presentation to simulate a well–organized, comprehensive, and readily understandable series of slides as would be given in an oral presentation. the text provides the reader with the sound bites that the lectu4rers present to explicate the slides. But as an added bonus, the text contains all the thoroughly referenced citations to the discussion for further examination by the reader. I find the presentation technique to be delightful and expect that other readers will have the same experience.′ – Leslie Z. Benet
The present volume features the principles of drug metabolism, followed by the enzymes and reactions of oxidation, reduction, and hydrolysis. A continuation is in preparation.