Multi–Step Organic Synthesis: A Guide Through Experiments

Combining theoretical knowledge of synthetic transformations, practical considerations, structural elucidation by interpretation of spectroscopic data as well as rationalization of structure–property relations, this textbook presents a series of 16 independent exercises, including detailed comments, questions, and answers. The comments are very helpful for guiding less experienced students toward a successful approach to problem–solving, while the broad scope of the questions and answers is excellent for learning purposes. The exercises are based on published research articles, adapted for didactic purposes, and will thus inspire students by way of having to solve real–life problems in chemistry.
A must–have for MSc and PhD students as well as postdocs in organic chemistry and related disciplines, and lecturers and organizers of lab courses in organic chemistry.

INTRODUCTION
PROBLEMS
SEN794
Atovaquone
Glucokinase activator
Oral H1–H3 Antagonist
Eletriptan
Muricatacin and analogues
(+)–Muricatacin
(–)–Muricatacin
(+)–epi–Muricatacin
Stemoamide and analogues
(–)–Stemoamide
(±)–9,10–bis–epi–Stemoamide
Leiodermatolide
(–)–Martinellic acid
Streptophenazine A
Caraphenols B and C


Nicolas Bogliotti is Assistant Professor at École normale supérieure Paris–Saclay, France. After his undergraduate studies at Université Nice Sophia–Antipolis, France, he obtained his MSc and PhD Degrees at Université Pierre et Marie Curie in Paris, France. He was a postdoc at ETH Zürich, Switzerland and Institut Curie, France, before his current position. His research interests focus on the synthesis of photosensitive molecules allowing visualization of recognition events, induction of a biological response and modulation of chemical reactivity.

Roba Moumné is Assistant Professor at Université Pierre et Marie Curie, France. She studied chemistry and completed her MSc and PhD at the same university. Before her current position, she was also a postdoctoral fellow at Max–Planck–Institut in Mülheim and der Ruhr, Germany, at University of Zürich, Switzerland and at Université Paris Descartes, France. Her research interests include bioorganic chemistry and peptide synthesis.