Bioorganometallic Chemistry: Applications in Drug Discovery, Biocatalysis, and Imaging

First defined in 1985, the field of bioorganometallic chemistry studies the role of metal ions or complexes in natural biological processes a well as the practicability of these results for the development of novel drugs, biosensors, radiopharmaceuticals, and artificial enzymes. This important field has continuously expanded over the past 25 years, and the first bioorganometallics have already been applied, including platin compounds for cancer chemotherapy and technetium compounds as nuclear medicine imaging agents. This up–to–date reference reflects the significant advances and key breakthroughs made over the last decade. The result is an overview of recent developments and future trends in the field, focusing on such applications as potentially active organometallic drugs for fighting currently incurable diseases, as well as in such areas as catalysis, energy, analytical chemistry, and imaging. Here, the renowned editor, who is responsible for coining the term "bioorganometallics", and his international team of experts have put together a valuable resource for researchers in organometallic, inorganic, medicinal, and biochemistry.

MEDICINAL CHEMISTRY Ruthenium and Osmium Complexes with Anticancer Properties Mechanisms of Action of Anticancer Ruthenium Complexes Mechanism of Action of Ferrocifens Organometallic Enzymes Inhibitors Mechanism of Actions of Ferroquines CO–Releasing Molecules METALLOPROTEINS, CATALYSIS, ENERGY Models of Hydrogenases Hydrogenases Artificial Metalloproteins BIOANALYSIS Organometallic Bioprobes for Cellular Imaging

Gérard Jaouen obtained his PhD degree in organic chemistry at the University of Rennes, France, in 1969. From 1973 to 1974 he did postdoctoral studies at the University of Cambridge, UK, working with Professor (now Lord) Jack Lewis. He became a member of the CNRS in 1970, was appointed Maitre de Recherche (Directeur de Recherche) in 1976 and became Professor at the École Nationale de Chimie in Paris in 1982, where in 1984 he set up a CNRS associated research unit. He is now appointed as a "classe exceptionnelle" professor. Professor Jaouen is the author of 400 papers and holds 14 patents. His achievements in bioorganometallic chemistry have been recognized by several awards. He was awarded "Chevalier dans l′ordre de la Legion d′Honneur" (Knight of the National Order of the Legion of Honour, 2006) and elected as a fellow of the European Academy of Sciences (2012). Michèle Salmain received her PhD degree in organic chemistry from the Université Pierre et Marie Curie, Paris, France in 1990. She has been appointed as a reseacher by the Centre National de la Recherche Scientifique since 1992 and currently holds a position of Directeur de Recherche. Her main research interest lies in the field of biochemistry, such as immunosensors for analytical applications and artificial metalloenzymes for enantioselective catalysis applications.