Marine Microbiology: Bioactive Compounds and Biotechnological Applications

Deliberately breaking with the classical biology–centered description of marine organisms and their products, this reference emphasizes microbial technology over basic biology, setting it apart from its predecessors. As such, it systematically covers the technology behind high–value compounds for use as pharmaceuticals, nutraceuticals or cosmetics, from prospecting to production issues. Following a definition of the field, the book goes on to address all industrially important aspects of marine microbial biotechnology. The first main part contains a description of the major production organisms, from archaebacteria to cyanobacteria to algae and symbionts, including their genetic engineering. The remaining four parts look at commercially important compounds produced by these microorganisms together with their applications. Throughout, the emphasis is on technological considerations, and the future potential of these organisms or compound classes is discussed. A valuable and forward–looking resource for innovative biotechnologists in industry as well as in academia.

Preface XIX Biography XXI List of Contributors XXIII 1 Introduction to Marine Actinobacteria 1 Panchanathan Manivasagan, Jayachandran Venkatesan, and Se–Kwon Kim 2 Treasure Hunting for Useful Microorganisms in the Marine Environment 21 Chiaki Imada 3 Strategy of Marine Viruses in Global Ecosystem 33 Amardeep Singh, Manoj Trivedi, Pranjal Chandra, and Rajendra N. Goyal 4 Taxonomic Study of Antibiotic–Producing Marine Actinobacteria 45 Priyanka Kishore, Neelam Mangwani, Hirak R. Dash, and Surajit Das 5 Marine Cyanobacteria: A Prolific Source of Bioactive Natural Products as Drug Leads 59 Lik Tong Tan 6 Marine Bacteria Are an Attractive Source to Overcome the Problems of Antibiotic–Resistant Staphylococcus aureus 83 Dae–Sung Lee, Sung–Hwan Eom, Myung–Suk Lee, and Young–Mog Kim 7 Marine Bacteria as Probiotics and Their Applications in Aquaculture 97 Chamilani Nikapitiya 8 Small–Molecule Antibiotics from Marine Bacteria and Strategies to Prevent Rediscovery of Known Compounds 127 Matthias Wietz, Maria Mansson, Nikolaj G. Vynne, and Lone Gram 9 Marine Bacteriophages for the Biocontrol of Fish and Shellfish Diseases 161 Mahanama De Zoysa 10 Marine Actinomycetes as Source of Pharmaceutically Important Compounds 173 M.L. Arvinda swamy 11 Antimicrobial Agents from Marine Cyanobacteria and Actinomycetes 191 Arnab Pramanik, Malay Saha, and Barindra Sana 12 Bioactive Compounds from Marine Actinomycetes 207 Ana M.—I∼niguez–Martínez, Graciela Guerra–Rivas, Nahara E. Ayala–S—anchez, and Irma E. Soria–Mercado 13 Fungal Bioactive Gene Clusters: A Molecular Insight 223 Ira Bhatnagar and Se–Kwon Kim 14 Anticancer Potentials of Marine–Derived Fungal Metabolites 237 Se–Kwon Kim and Pradeep Dewapriya 15 Antifungal and Antimycotoxin Activities of Marine Actinomycetes and Their Compounds 247 Pei–Sheng Yan, Li–Xin Cao, and Jing Ren 16 Antituberculosis Materials from Marine Microbes 261 Quang Van Ta and Se–Kwon Kim 17 Harnessing the Chemical and Genetic Diversities of Marine Microorganisms for Medical Applications 267 Xinqing Zhao, Wence Jiao, and Xiaona Xu 18 Marine Symbiotic Microorganisms: A New Dimension in Natural Product Research 295 S.W.A. Himaya and Se–Kwon Kim 19 Application of Probiotics from Marine Microbes for Sustainable Marine Aquaculture Development 307 Nguyen Van Duy, Le Minh Hoang, and Trang Sy Trung 20 Antimicrobial Properties of Eicosapentaenoic Acid (C20 : 5n—3) 351 Andrew P. Desbois 21 Bioprospecting of Marine Microbial Symbionts: Exploitation of Underexplored Marine Microorganisms 369 Ocky K. Radjasa 22 Marine Microorganisms and Their Versatile Applications in Bioactive Compounds 379 Sougata Jana, Arijit Gandhi, Samrat Chakraborty, Kalyan K. Sen, and Sanat K. Basu 23 Metabolites of Marine Microorganisms and Their Pharmacological Activities 393 Kustiariyah Tarman, Ulrike Lindequist, and Sabine Mundt 24 Sponges: A Reservoir for Microorganism–Derived Bioactive Metabolites 417 Visamsetti Amarendra, Ramachandran S. Santhosh, and Kandasamy Dhevendaran 2 5 Bioactive Marine Microorganisms for Biocatalytic Reactions in Organic Compounds 453 Lenilson C. Rocha, Julieta R. de Oliveira, Bruna Vacondio, Gisele N. Rodrigues, Mirna H. Regali Seleghim, and Andre L. Meleiro Porto 26 Marine Microbial Enzymes: Biotechnological and Biomedical Aspects 491 Barindra Sana 27 Biomedical Applications of Mycosporine–Like Amino Acids 509 Richa and Rajeshwar P. Sinha Acknowledgment 526 References 526 Index 535

Se–Kwon Kim is Professor of Marine Biochemistry at Pukyong National University in Busan, South Korea. A graduate of PKNU, he conducted his postdoctoral studies at the University of Illinois (USA), and was a visiting scientist at the Memorial University of Newfoundland (Canada). His major research interests are the investigation and development of bioactive substances derived from marine organisms and their application as cosmeceuticals and nutraceuticals. Professor Kim is the current editor–in–chief of the Korean Journal of Marine Bioscience and Biotechnology . He has authored over 450 research papers, holds 72 patents, and has written or edited more than 30 books.