RNA Regulation, 2 Volumes

Since it was first considered that RNA could function as both messenger and part of the translation machinery, RNAs have been found to be versatile molecules that not only play key roles in many important biological processes – like splicing, editing, protein export among others – but can also act catalytically and have many complex regulatory roles in cellular processes. There is still much work to be done before we fully understand RNA’s diverse nature, let alone all of its roles in both healthy and diseased states. With each contributor carefully selected and a recognized expert in his or her field, these two volumes bring together the different functions of the various forms of RNA in a comprehensive overview, with special focus on the different forms of gene expression regulation, which have potential applications in health and disease.  

Preface IX Volume 1 Part I Molecular Cell Biology 1 1 RNA Regulation in Apoptosis 3 Christopher von Roretz and Imed–Eddine Gallouzi 2 Bacterial trans–Translation: From Functions to Applications 47 Emmanuel Giudice and Reynald Gillet 3 RNA–mediated Control of Bacterial Gene Expression: Role of Regulatory non–Coding RNAs 81 Pierre Mandin, Alejandro Toledo–Arana, Aymeric Fouquier d’H´erouel and Francis Repoila 4 Functions and Applications of RNA–Guided CRISPR–Cas Immune Systems 117 Rodolphe Barrangou and Philippe Horvath 5 RNA Regulation in Myogenesis 141 Andrie Koutsoulidou, Nikolaos P. Mastroyiannopoulos and Leonidas A. Phylactou 6 Regulation of Animal Gene Expression by Ingested Plant Small RNAs 169 Xi Chen, Lin Zhang and Chen–Yu Zhang 7 RNA Interference in Animals 185 Mikiko C. Siomi 8 To Translate or Degrade: Cytoplasmic mRNA Decision Mechanisms 211 Daniel Beisang and Paul R. Bohjanen 9 RNA Modification 237 Yuri Motorin and Bruno Charpentier 10 Regulation of Gene Expression 285 Anil Kumar, Sarika Garg and Neha Garg 11 RNA Silencing in Plants 345 Charles W. Melnyk and C. Jake Harris 12 mRNA Stability 391 Ashley T. Neff, Carol J. Wilusz and Jeffrey Wilusz 13 Visualization of RNA and RNA Interactions in Cells 417 Natalia E. Broude 14 RNA as a Regulator of Chromatin Structure 437 Yota Murakami 15 Intracellular RNA Localization and Localized Translation 471 Florence Besse 16 tRNA Subcellular Dynamics 513 Tohru Yoshihisa Volume 2 Part II Methods for Analysis and Manipulation of RNA–mediated Regulation 545 17 RNA Methodologies 547 Robert E. Farrell, Jr. 18 Bacterial Vectors for RNAi Delivery to Cancer Cells 585 Hermann Lage 19 RNAi Screening and Assays 605 Marie Lundbæk and Pa¢ª l Sætrom Part III Medical Applications 631 20 Translation Regulation by microRNAs in Acute Leukemia 633 Christos K. Kontos, Diamantina Vasilatou, Sotirios G. Papageorgiou and Andreas Scorilas 21 Cancer Stem Cells 663 Mei Zhang and Jeffrey M. Rosen 22 RNAi Synthetic Logic Circuits for Sensing, Information Processing, and Actuation 687 Zhen Xie, Liliana Wroblewska and Ron Weiss 23 Emerging Clinical Applications and Pharmacology of RNA 711 Sailen Barik and Vira Bitko 24 RNAi to Treat Chronic Hepatitis C Infection 751 Usman Ali Ashfaq, Saba Khaliq and Shah Jahan 25 RNAi Gene Therapy to Combat HIV–1 Infection 781 Pierre Corbeau 26 Virus–Encoded microRNAs 807 Lee Tuddenham and S´ebastien Pfeffer Index 849

Dr. Robert A. Meyers , the Editor in Chief (EiC) of the Encyclopedia of Cell and Molecular Biology and Molecular Medicine, originated the Encyclopedia and continues responsibility for the project. Dr. Meyers has a Ph.D. in organic chemistry from UCLA and was a postdoctoral and faculty member at the California Institute of Technology. He is president of Ramtechlimited and is author or editor in chief of an additional twelve books and 20 technical papers as well as ten patents.