Metathesis in Natural Product Synthesis: Strategies, Substrates and Catalysts

The tremendous success of the so–called metathesis reaction during the last decade (Nobel prize 2005) is reflected in its huge impact on natural product synthesis and related fields. A very significant portion of contemporary total syntheses comprises at least one metathetic conversion; while many of them rely on metathesis as the key strategic element.
Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications.
From the contents:
∗ Synthesis of natural products containing medium–size carbocycles, macrocycles, oxygen and nitrogen heterocycles by ring–closing alkene metathesis
∗ Phosphorus and sulfur heterocycles
∗ Tethered ring–closing metathesis
∗ Metathesis involving a relay and applications in natural products synthesis
∗ Ene–yne metathesis
∗ Ring–closing alkyne metathesis
∗ Cross, cascade and asymmetric metathesis
∗ Solid–phase metathesis reactions
Written by top international authors, this is a real must–have for anyone working in natural product synthesis.


Spis treści:
Synthesis of Natural Products Containing Medium–Size Carbocycles by Ring–Closing Alkene Metathesis
Natural Products Containing Medium–Sized Nitrogen Heterocycles Synthesized by Ring–Closing Alkene Metathesis
Synthesis of Natural Products Containing Medium–Size Oxygen Heterocycles by Ring–Closing Alkene Metathesis
Phosphorus and Sulfur Heterocycles via Ring–Closing Metathesis: Application in Natural Product Synthesis
Synthesis of Natural Products Containing Macrocycles by Alkene Ring–Closing Metathesis
Synthesis of Natural Products and Related Compounds Using Ene– Yne Metathesis
Ring–Closing Alkyne Metathesis in Natural Product Synthesis
Temporary Silicon–Tethered Ring–Closing Metathesis Reactions in Natural Product Synthesis
Metathesis Involving a Relay and Applications in Natural Product Synthesis
Cross–Metathesis in Natural Products Synthesis
Cascade Metathesis in Natural Product Synthesis
Catalytic Enantioselective Olefin Metathesis and Natural Product Synthesis
Metathesis Reactions in Solid–Phase Organic Synthesis

Nota biograficzna:
Janine Cossy graduated from the University of Reims. After a postdoctoral stay with Barry Trost (1980–1982) at the University of Wisconsin, she returned to Reims where she became Director of Research of the CNRS in 1990. In the same year she moved to Paris to become Professor of Organic Chemistry at the ESPCI (Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris). She has published more than 330 articles and 12 patents in the field of synthetic organic chemistry and natural product synthesis. She is Associate Editor at Organic Letters since 2005.
Stellios Arseniyadis completed his PhD in 2002 with Dr. C. Mioskowski at the Universite Louis Pasteur (Strasbourg) and joined Rhodia Chirex (Boston) for an 18 months military service. After a first postdoctoral fellowship with Professor A. C. Spivey at Imperial College, he joined Professor K. C. Nicolaou′s group at The Scripps Research Institute. In 2005 he was appointed a CNRS researcher position in the group of Professor Cossy. His research interests include the development of new methods in the field of asymmetric synthesis and their application to natural product synthesis.
Christophe Meyer graduated from the Ecole Nationale Superieure de Chimie de Paris in 1991 and received his PhD from University Pierre et Marie Curie (Paris) in 1994 under the supervision of Professor Jean–Francois Normant and Doctor Ilan Marek. After a postdocto ral stay at the University of Toronto (Canada) in the laboratory of Professor Mark Lautens, he was appointed Charge de Recherche at the CNRS in 1996 in the group of Professor Janine Cossy (ESPCI). His research focuses on the development of synthetic methodologies and total synthesis of natural products.

Okładka tylna:
The tremendous success of the so–called metathesis reaction during the last decade (Nobel prize 2005) is reflected in its huge impact on natural product synthesis and related fields. A very significant portion of contemporary total syntheses comprises at least one metathetic conversion; while many of them rely on metathesis as the key strategic element.
Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications.
From the contents:
∗ Synthesis of natural products containing medium–size carbocycles, macrocycles, oxygen and nitrogen heterocycles by ring–closing alkene metathesis
∗ Phosphorus and sulfur heterocycles
∗ Tethered ring–closing metathesis
∗ Metathesis involving a relay and applications in natural products synthesis
∗ Ene–yne metathesis
∗ Ring–closing alkyne metathesis
∗ Cross, cascade and asymmetric metathesis
∗ Solid–phase metathesis reactions
Written by top international authors, this is a real must–have for anyone working in natural product synthesis.