Reactive Intermediates: MS Investigations in Solution

Edited by a top expert, this book represents a powerful tool showing how to successfully apply ESI–MS in revealing, elucidating and helping to consolidate several proposed mechanisms of organic reactions that need to be emphasized.
With a foreword by Chris Enke

Spis treści:
Foreword.
Preface.
List of Contributors.
1 A Brief Overview of the Mechanisms Involved in Electrospray Mass Spectrometry (Paul Kebarle and Udo H. Verkerk).
1.1 Introduction.
1.2 Production of Gas–Phase Ions by Electrospray and Electrospray Ionization Mass Spectrometry.
2 Historical Perspectives in the Study of Ion Chemistry by Mass Spectrometry: From the Gas Phase to Solution (Hao Chen).
2.1 A Brief History and Recent Advances in Mass Spectrometry.
2.2 Overview of the Study of Ion/Molecule Reactions in the Gas Phase by Mass Spectrometry.
2.3 Future Perspectives.
3 Organic Reaction Studies by ESI–MS (Fabiane M. Nachtigall and Marcos N. Eberlin).
3.1 Introduction.
3.2 Reaction Mechanisms.
3.3 General Remarks.
4 Studies of Reaction Mechanism Intermediates by ESI–MS (Rong Qian, Jing Zhou, Shengjun Yao, Haoyang Wang, and Yinlong Guo).
4.1 Introduction.
4.2 Studies on the Intermediates and Mechanisms of Pd–Catalyzed Reactions.
4.3 Studies on Some Reactive Intermediates and Mechanisms of Radical Reactions.
4.4 Studies on the Intermediates and Mechanism of Organocatalysis Reactions.
4.5 Studies on the Intermediates and Mechanism of Transition Metal–Catalyzed Polymerization Reactions.
5 On–line Monitoring Reactions by Electrospray Ionization Mass Spectrometry (Leonardo S. Santos).
5.1 Introduction.
5.2 Preservation of the Charge in the Transit of Ions from Solution to the Gas Phase Using the ESI Technique.
5.3 Developing Methods to Study Reaction Mechanisms.
5.4 Probing Reactivity of Intermediates.< br>5.5 Conclusion.
6 Gas Phase Ligand Fragmentation to Unmask Reactive Metallic Species (Richard A. J. O.Hair).
6.1 Introduction and Scope of the Review.
6.2 Unmasking Reactive Metallic Intermediates via Collision–Induced Dissociation.
6.3 Conclusions.
7 Palladium Intermediates in Solution (Anna Roglans and Anna Pla–Quintana).
7.1 Introduction.
7.2 ESI–MS Studies in Suzuki–Miyaura Cross–Coupling and Related Reactions.
7.3 ESI–MS Studies in the Identification of Oxidative Addition Intermediates.
7.4 ESI–MS Studies in Mizoroki–Heck and Related Reactions.
7.5 ESI–MS Studies in Stille Cross–Coupling Reactions.
7.6 ESI–MS Studies in Palladium–Catalyzed Reactions Involving Allenes.
7.7 ESI–MS Studies in Palladium–Catalyzed Alkynylation Reactions.
7.8 ESI–MS Studies in Palladium–Catalyzed Allylic Substitution Reactions.
7.9 ESI–MS Studies in Palladium–Catalyzed Oxidation of 2–Allylphenols.
7.10 ESI–MS Studies in Palladium–Catalyzed Polymerization Reactions.
7.11 Conclusions.
8 Practical Investigation of Molecular and Biomolecular Noncovalent Recognition Processes in Solution by ESI–MS (Kevin A. Schug).
8.1 Introduction.
8.2 Methods and Applications.
8.3 Practical Aspects of Titration Analysis.
8.4 Summary and Outlook.
References.
Index.

Nota biograficzna:
After being awarded his MSc in 1999 Leonardo Silva Santos joined the Universidade Estadual de Campinas in Brasil for his thesis working on the total synthesis of natural products, while also doing research for two years at the University of Chicago in 2001–2002. After beind awarded his Ph.D. in 2003 he did postdoctoral research at UNICAMP, Brasil, and at the Carl von Ossietzky Universität Oldenburg. He is currently Professor at the Universidad de T alca, Chile.