The Chemical Biology of DNA Damage

A modern reference on a key topic in biochemical toxicology that reaches out into molecular biology, molecular medicine and environmental science, The Chemical Biology of DNA Damage covers basic concepts as well as the analysis and prediction of genotoxicty at the molecular level.

Spis treści:
CHEMISTRY AND BIOLOGY OF DNA LESIONS
Chemical biology of DNA adducts: Origins, formation and impact
Inflammation and DNA damage
Chemical pathways of oxidative DNA damage by reactive oxygen species
DNA adducts from lipid oxidation
Polycyclic aromatic hydrocarbons: Multiple pathways of formation of DNA lesions
Heterocyclic aromatic amines as food mutagens
The genotoxic endogenous and exogenous estrogen pathway and DNA damage
UNDERSTANDING STRUCTURE–FUNCTION RELATIONSHIPS AND BIOLOGICAL ACTIVITY
Overview
NMR solution structures of small DNA lesions
Structures of bulky lesions from NMR studies
DNA base sequence effects on structures of aromatic amine–guanine adducts in solution
Insight into base excision repair of oxidative lesions
Structure–function relationships in nucleotide excision repair
Transcription and transcription–coupled repair
X–ray crystallographic studies of DNA lesions in polymerases
Modeling polymerases containing DNA lesions at their active sites
Bulky DNA lesions for probing polymerase switching phenomena in translesion DNA replication

Nota biograficzna:
Nicholas E. Geacintov is Professor of Chemistry and currently the Chair of the Department of Chemistry at New York University. He received his PhD degree in physical chemistry from Syracuse University and spent most of his career at NYU. His current research interests are focused on electron transfer and radical reactions in DNA, and the chemistry and biology of DNA damage. He has published over 300 manuscripts and is currently serving on the Editorial Board of the Journal of Biologi cal Chemistry.
Suse Broyde is Professor of Biology and Affiliate Professor of Chemistry at New York University. Her research interests have focused for many years on computer modeling of DNA lesions in solution and more recently in DNA polymerases and repair enzymes with the goal of elucidating structure function relationships. She holds a PhD degree in physical chemistry with a minor in physics from the Polytechnic Institute of New York and has published over 160 papers in peer–reviewed journals. She is currently a member of the Editorial Advisory Board of Chemical Research in Toxicology.