New Strategies Combating Bacterial Infection

Combating bacterial infections calls for multidisciplinary approach and this is what is on offer here. Written by an experienced international team of researchers from various fields ranging from biotechnology to traditional medicine, the book provides complete comprehensive coverage of topics relevant to new antibacterial drugs.
Divided into three sections, the first describes the problem of drug resistance an the need for new drugs, while the second treats recent trends and new classes of drugs, including relevant developments in transcriptomics and proteomics leading to new antimicrobial drug discovery, and a new generation of antibiotics and non–antibiotics. The third section on natural products discusses the antibacterial action of phytocompounds, plant extracts, essential oils and honey as well as the role of robotics in bacterial infections.
Invaluable to student so medicine, pharmaceutical sciences, phyto–medicine and microbiology and all those wanting to know about the possibilities and limitations of new antibacterial drugs,. Furthermore, its coverage of plants and other natural products makes this relevant to the pharmaceutical and herbal industries.

Spis treści:
Preface.
List of Contributors.
1. Molecular Mechanisms of Antibiotic Resistance: The Need for Novel Antimicrobial Therapies (John W. Dale–Skinner and Boyan B. Bonev).
1.1. Introduction.
1.2. Molecular Mechanisms of Resistance.
1.3. B–Lactams.
1.4. Glycopeptides.
1.5. Lantibiotics.
1.6. Aminoglycosides.
1.7. Macrolides.
1.8. Tetracyclines.
1.9. Fluoroquinolones.
1.10. Conclusions.
References.
2. Novel Approaches to Combat Drug–Resistant Bacteria (Iqbal Ahmad, Maryam Zahin, Farrukh Aqil, Mohd Sajjad Ahmad Khan, and Shamim Ahmad).
2.1. Introduction.
2.2. Approaches to Antibacterial Drug Discovery and Combating the Problem of Drug Resistance.
2.3. Combination Drug Therapy.< br>2.4. Strategies to Target Mechanism of Drug resistance.
2.5. Quorum Sensing Inhibition: A Novel Anti–Infective Drug Target.
2.6. Phage Therapy: An Alternative Therapy.
2.7. Antibiotic Use Policy: Practical Management of the Problem of Antibiotic Resistance.
2.8. Conclusions.
3. Promising Current Drug Candidates in Clinical Trials and Natural Products Against Multidrug–resistant Tuberculosis (Marcus Vinicius and Nora de Souza).
3.1. Introduction.
3.2. Current MDR–TB Treatment.
3.3. Current Drugs in Development Against MDR–TB.
3.4. Natural Products Against MDR–TB.
3.5. References.
4. Non–antibiotics – An Alternative for Microbial Resistance: Scope and Hope (Debprasad Chattopadhyay, Soumen Kumar Das, Arup Ranjan Patra, and Sujit Kumar Bhattacharya).
4.1. Introduction.
4.2. Historical Development: Non–antibiotics with Antimicrobial Potential.
4.3. Psychotherapeutics as N on–antibiotics.
4.4. Sedatives and Tranquilizers as Non–antibiotics.
4.5. Antihistaminics as Non–antibiotics.
4.6. In vitro and In vivo Antimicrobial Potential of Non–antibiotics.
4.7. Single and Combined Activity Against Bacteria.
4.8. Synergism and ′Reversal of Resistance′: A Special Synergy.
4.9. Mechanism of Action of Non–antibiotics.
4.10. Conclusions.
5. Use of Natural Products to Combat Multidrug–Resistant Bacteria (Christine M. Slover, Larry H. Danziger, Bolanle A. Adeniyi, and Gail B. Mahady).
5.1. Introduction.
5.2. Natural Product Development.
5.3. MRSA.
5.4. Natural Products for MDR Microorganisms.
6. West African Plans and Related Phytocompounds with Anti–Multidrug–Resistance Activity (Kone Mamidou Witabouna and Kamanzi Atindehou Kagoyire).
6.1. Introduction.
6.2. MDR Bacteria in West Africa.
6.3. Plants Used in Bacterial Disease treatment in West Africa.
6.4. W est African Medicinal Plants with Activity against MDR Bacteria.
6.5. Metabolites Isolated from West African Medicinal Plants Effective on MDR Bacteria.
6.6. Conclusions.
7. Essential Oils and New Antimicrobial Strategies (Sabulal Baby and Varughese George).
7.1. Introduction : Essential Oils.
7.2. Biosynthetic Origin.
7.3. Extraction of Essential Oils.
7.4. Storage of Essential Oils.
7.5. Chemical Analysis of Essential Oils.
7.6. Physical Parameters.
7.7. Olfactory Evaluation.
7.8. Essential Oils as Antimicrobials.
7.9. Antimicrobial Activity: Mode of Action.
7.10. Antimicrobial Assays.
7.11. Other Applications of Essential Oils.
7.12. Toxicity of Essential Oils.
7.13. Scope for Future Research.
8. Application of Plant Extracts and Products in Veterinary Infections (Jacobus N. Eloff and Lindy J. McGaw).
8.1. Introduction.
8.2. Veterinary Infectious Diseases and their Significance.
8.3. Plants as Sources of Antimicrobial Compounds.
8.4. Antibiotic Resistance and the Impact of Antibiotic Feed Additives.
8.5. Plants as Replacements for Antibiotic Feed Additives.
8.6. Conclusions.
9. Honey: Antimicrobial Actions and role in Disease Management (Peter Molan).
9.1. Introduction.
9.2. Nature of the Antimicrobial Activity of Honey.
9.3. Spectrum and Potency of the Antimicrobial Activity of Honey.
9.4. Other Actions.
9.5. Clinical Uses of Honey as an Antimicrobial Agent.
9.6. Clinical Evidence for Effectiveness of Honey on Infected Wounds.
9.7. Resistant Bacteria.
9.8. Benefits Apart from control of Infection in Topical treatment with Honey.
9.9. Future Directions.
10. Honey: Biological Characteristics and Potential role in Disease Management (Mohammed Shahid).
10.1. Introduction.
10.2. biological Characteristics of Honey.
10.3. Antibacterial Potential of Honey.
10.4. Potential Use of Honey as an Antibacterial Agent.
10.5. Use of Honey against Multidrug resistance.
10.6. Conclusions.
11. Probiotics: Benefits in Human Health and Bacterial Disease Management (Maria Carmen Collado and Yolanda Sanz).
11.1. Gut Microbiota.
11.2. Probiotics, Intestinal Microbiota and Host Health.
11.3. Studies on the Management and Prevention of Diseases.
11.4. Clinical Prospects of Gut Microbiota Research.
Index.

Nota biograficzna:
Iqbal Ahmad is a Senior Faculty of microbiology at Aligarh Muslim University (AMU), India, and Principal Investigator of a research project on "Anti–quorum Sensing Activity of natural Products" of the University Grant commission, New Delhi. he gained his M. Phil, and Ph.D. in microbiology from AMU carrying out his doctoral research at the central Drug research Institute, Lucknow, India. Iqbal Ahmad had worked on plasmid biology of E. coli, bacterial virulence and pathogenicity, drug resistance, microbial ecology, metal–microbe interactions, plant–bacteria interactions, bioactivities and therapeutic potentials of Indian medicinal plants. recent research interests include quorum sensing modulation by natural products and exploring novel anti–infective compounds against drug resistant microbial pathogens. Iqbal Ahmad hads published more than 50 original research papers and edited three books.
Farrukh Aqil is currently a post doctoral scholar at the University of Louisville, USA, with Ramesh C. Gupta in the cancer chemoprevention group. He has completed his studies in microbiology with Iqbal Ahmad from Aligarh Muslim University, India. He worked on bacterial drug resistance and bioactivities of potential Indian medicinal plants which includes in vitro antimicrobial, antioxidant and antimutagenic properties. before moving to the USA he has been lecture for microbiology and biotechnology at Integral University, Lucknow, India. His research interest has a focus on anticancer bioactive compounds from nat ural products and its efficacy in vitro and in animal models. Farrukh Aqil has published 16 research papers and edited one book.

Okładka tylna:
Combating bacterial infections calls for multidisciplinary approach and this is what is on offer here. Written by an experienced international team of researchers from various fields ranging from biotechnology to traditional medicine, the book provides complete comprehensive coverage of topics relevant to new antibacterial drugs.
Divided into three sections, the first describes the problem of drug resistance an the need for new drugs, while the second treats recent trends and new classes of drugs, including relevant developments in transcriptomics and proteomics leading to new antimicrobial drug discovery, and a new generation of antibiotics and non–antibiotics. The third section on natural products discusses the antibacterial action of phytocompounds, plant extracts, essential oils and honey as well as the role of robotics in bacterial infections.
Invaluable to student so medicine, pharmaceutical sciences, phyto–medicine and microbiology and all those wanting to know about the possibilities and limitations of new antibacterial drugs,. Furthermore, its coverage of plants and other natural products makes this relevant to the pharmaceutical and herbal industries.