Post–Transcriptional Gene Regulation: RNA Processing in Eukaryotes

Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post–transcriptional gene regulation thereby focussing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA editing and others, the book also discusses the critical role of RNA processing for the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, clinics as well as pharmaceutical industry.

Spis treści:
Transcription and Splicing
Transcription Termination
Histone RNA Processing
SnRNP Biogenesis/Protein Arginine Methylation
Pre–mRNA Splicing & Catalytic Mechanisms
Alternative Splicing Regulation in the Nervous System, Impact & Mechanism
Visualization and Manipulation of Alternative Splicing in Vivo
Splicing Regulation and Diseases
Translation Control
Nonsense–mediated mRNA Decay
RNA Interference
Evolution of Non–protein Coding RNA Genes
Additional Chapters will added on the topics of:
1. non–coding ncRNA:
2.miRNA;
3. RNA modifications [directed by C/D and H/ACA box snoRNAs ]
4. RNA editing


Nota biograficzna:
Dr. Jane Y. Wu is the Charles Louis Mix Professor in Neurology at Lurie Cancer Center and the Center for Genetic Medicine of Northwestern University in Chicago, USA. Having obtained her degree from Stanford Univeristy and postdoctoral training at Harvard University, Dr. Wu has been studying molecular mechanisms underlying pre–mRNA splicing and neurodevelopment/degeneration, both linking basic biology to human diseases.