The Sugar Code: Fundamentals of Glycosciences

A reader friendly, strategically structured introduction to glycosciences, guiding from the basics of the sugar alphabet and pertinent aspects of chemical/natural glycosylation to functional carbohydrate recognition (sugar code), with an eye on emerging medical relevance. All chapters, intimately connected by cross–referencing, share the same interdisciplinary level to make the information readily digestible. Story–telling info boxes add an entertaining touch.
Written by a team of renowned glycoscientists from the forefront of research with the clear intention to convey their enthusiasm for teaching key lessons and edited by a leading figure of the field, this book is a perfect primer for students in life and medical sciences and for specialists looking for a concise overview. With its remarkable set of summary illustrations and its focus on landmark references, it is ideally suited as practical resource to teach classes, run courses and get prepared for contributing to the dynamic development of glycosciences.
Supplementary Material is available at www.wiley–vch.de/home/thesugarcode

Spis treści:
CHEMICAL BASIS
The Biochemical Basis and Coding Capacity of the Sugar Code (Rudiger, Gabius)
Three–dimensional Aspects of the Sugar Code (Kozar, Andre, Ulicny, Gabius)
The Chemist′s Way to Synthesize Glycosides (Oscarson)
The Chemist′s Way to Prepare Multivalency (Chabre, Roy)
Analytical Aspects: The Analysis of Protein–Bound Glycans (Nakagawa)
NATURAL GLYCOSYLATION –
GLYCOPROTEINS
N–Glycosylation (Zuber, Roth)
O–Glycosylation: Structural Diversity and Functions (Patsos, Corfield)
Glycosylation of Model and "Lower" Organisms (Wilson, Paschinger, Rendic)
Glycosylphosphatidylinositol Anchors: Structure, Biosynthesis and Functions (Shams–Eldin, Debierre–Grockiego, Schwarz)
NATURAL GLYCOSYLATION –
GLYCOLIPIDS, PROTEOGLYCANS, CH ITIN
Glycolipids (Kopitz)
Proteoglycans (Buddecke)
Chitin (Merzendorfer)
PROTEIN–CARBOHYDRATE INTERACTIONS
Protein–Carbohydrate Interactions: Basic Concepts and Methods for Analysis (Solis, Romero, Menendez, Jimenez–Barbero)
How to Determine Specificity: From Lectin Profiling to Glycan Mapping and Arrays (Tateno, Kuno, Hirabayashi)
The History of Lectinology (Rudiger, Gabius)
Ca2+: Mastermind and Active Player for Lectin Activity (Including a Gallery of Lectin Folds) (Gabius)
Bacterial and Viral Lectins (Holgersson, Gustafsson, Gaunitz)
Plant Lectins (Rudiger, Gabius)
Animal and Human Lectins (Gabius)
Routes in Lectin Evolution: Case Study on the C–Type Lectin–Like Domains (Gready, Zelensky)
Carbohydrate–Carbohydrate Interactions (Bucior, Burger, Fernandez–Busquets)
BIOMEDICAL ASPECTS AND CASE STUDIES
Diseases of Glycosylation (Hennet)
Animal Models to Delineate Glycan Functionality (Honke, Taniguchi)
Glycobiology of Fertilization and Early Embryonic Development (Habermann, Sinowatz)
Glycans as Functional Markers in Malignancy? (Andre, Kopitz, Kaltner, Villalobo, Gabius)
Small is Beautiful: Mini–Lectins in Host Defense (Lehrer)
Inflammation and Glycosciences (Schwartz–Albiez)
Sugars as Pharmaceuticals (Osborn, Turkson)
Platelet Glycoproteins as Lectins in Hematology (Hoffmeister, Falet)
Neurobiology meets Glycosciences (Ledeen, Wu)
COMPANION WEB–SITE: www.wiley–vch.de/home/thesugarcode

Nota biograficzna:
Hans–Joachim Gabius studied biochemistry at the University of Hannover and the University of California San Diego. He received his PhD degree in 1982 for investigating proofreading mechanisms by phenylalanyl–tRNA synthetases, then starting his contribution to glycosciences in 1983 at the Max–Planck–Institute for Experimental Medicine in Göttingen with his discovery and characterizatio n of lectins in tumors. Following an appointment as associate professor for pharmaceutical chemistry from 1991–1993 at the Philipps–University Marburg he became chairman of the Institute for Physiological Chemistry in the Faculty of Veterinary Medicine of the Ludwig–Maximilians–University Munich. Hans–Joachim Gabius received numerous research awards including the Otto–Hahn–Medal of the Max–Planck–Society, and awards of the Dr. Carl–Duisberg Foundation and the Paul–Martini Foundation. He has published over 500 research articles in peer–reviewed journals with over 13,000 citations and an h–factor of 59, this resource for teaching and self–study being the fifth book for which he served as editor.

Okładka tylna:
A reader friendly, strategically structured introduction to glycosciences, guiding from the basics of the sugar alphabet and pertinent aspects of chemical/natural glycosylation to functional carbohydrate recognition (sugar code), with an eye on emerging medical relevance. All chapters, intimately connected by cross–referencing, share the same interdisciplinary level to make the information readily digestible. Story–telling info boxes add an entertaining touch.
Written by a team of renowned glycoscientists from the forefront of research with the clear intention to convey their enthusiasm for teaching key lessons and edited by a leading figure of the field, this book is a perfect primer for students in life and medical sciences and for specialists looking for a concise overview. With its remarkable set of summary illustrations and its focus on landmark references, it is ideally suited as practical resource to teach classes, run courses and get prepared for contributing to the dynamic development of glycosciences.
Supplementary Material is available at www.wiley–vch.de/home/thesugarcode