Modern Biocatalysis: Stereoselective and Environmentally Friendly Reactions

This reference covers the wide and rapidly growing field of biocatalysis. It combines complementary expertise from such areas as microbiology, enzymology, molecular biology, structural biology and organic chemistry, this highlighting the interdisciplinary nature of the subject. With its special focus on progress and new developments towards environmentally beneficial reactions with high levels of selectivity for the production of key compound classes, this book will enlighten both chemists and biologists as to the advances and opportunities existing in enzyme catalysis.

Spis treści:
Preface.
List of Contributors.
1. Fluorescence Assays for Biotransformation (Jean–Louis Reymond).
2. Immobilization as a Tool for Improving Enzymes (Ulf Hanefeld).
3. Continuous–flow Microchannel Reactors with Surface–Immobilized biocatalysts (Malene S. Thomsen and Bernd Nidetzky).
4. Activity and Stability of Proteases in Hydrophilic Solvents (Lars Haastrup Pedersen, Sinthuwat Ritthitham, and Morten Kristensen).
5. Importance of Enzyme Formulation for the Activity and Enantioselectivity of Lipases in Organic Solvents (Francesco Secundo).
6. Direct Esterification with Dry Mycelia of Molds: a (Stereo) selective, Mild and Efficient Method for Obtaining Structurally Diverse Esters (Francesco Molinari, Diego Romano, Raffaella Gandolfi, Lucia Gardossi, Ulf Hanefeld, Attilio Converti and Patrizia Spizzo).
7. Factors Affecting Enantioselectivity: Allosteric Effects (Elisabeth Egholm Jacobsen and Thorlief Anthonsen).
8. Kinetic Resolution of Sec–alcohol in Non–conventional Media (Maja Habulin, Mateja Primozic and Zeljko Knez).
9. Strategies for the biocatalyst Lipophilization of Phenolic Antioxidants (Maria H. Katsoura, Eleni Theodosiou, Haralambos Stamatis and Fragiskos N. Kolisis).
10. Biocatalysis Applied to the Synthesis of Nucleoside Analogs (Vincente Gotor).
11. Efficient Fructooligosaccharide Synthesi s with a Fructosyltransferase from Aspergillus aculeatus (Francisco J. Plou,Miguel Alcalde, Iraj Ghazi, Lucia Fernandez–Arrojo and Antonio Ballesteros).
12. Hydantoin Racemase: the Key Enzyme for the Production of Optically Pure x–Amino Acids (Francisco Javier Las Heras–Vazquez, Josefa Maria Clemente–Jimenez, Sergio Martinex–Rodriguez and Felipe Rodriguez–Vico).
13. Chemo–enzymatic Deracemization Methods (Davide Tessaro, Gianluca Molla, Lorendano Pollegioni and Stefano Servi).
14. Nitrilases from Filamentous Fungi (Ludmila Martinkova, Vojtech Vejvoda, Ondrej Kaplan, Vladimir Kren, Karel Bezouska and Maria Cantarella).
15. Nitrilase– and Nitrile Hydratase–catalyzed Enantioselective Preparation of Non–proteinogenic Amino Acids (Morbert Klempier and Margit Winkler).
16. Nitrilases in the Enantioselective Synthesis of x–Hydroxycarboxylic Acids (Fred van Rantwijk, cesar Mateo, Andrzej Chmura, Bruno C. M. Fernandes and Roger A. Sheldon).
17. UF–Membrane bioreactors for Kinetics Characterization of Nitrile Hydratase–Amidase–catalyzed reactions: a Short Survey (Maria Cantarella, Alberto Gallifuoco, Agata Spera, Laura Cantarella, Ondrej Kaplan and Ludmila Martinkova).
18. Enzymes Catalyzing C–C bond Formation for the Synthesis of Monosaccharide Analogs (Laurence Hecquet, Virgil Helaine, Franck Charmantray and Marielle Lemaire).
19. Novel Strategies in Aldolase–catalyzed Synthesis of Iminosugars (Pere Clapes, Georg A. Sprenger and Jesus Joglar).
20. Biocatalytic Asymmetric Oxidations with Oxygen (Roland Wohlgemuth).
21. Second Generation Baeyer–Villiger Biocatalysts (Veronique Alphand, Marco W. Fraaije, Marko D. Mihovilovic and Gianluca Ottolina).
Index.

Nota biograficzna:
Wolf–Dieter Fessner obtained his PhD from the University of Freiburg, following which he carried out postdoctoral research at Harvard University with George Whitesides and at the University of Southern California with George Olah. Since 1998 he has been Full Professor of Organic Chemistry at the Technische Universität Darmstadt. His primary research interest is focused on the development of practical methods for enzymatic carbon–carbon bond formation and oligosaccharide synthesis, and on the interface between chemical and biological catalysis.
Thorleif Anthonsen is Professor of Organic Chemistry at The Norwegian University of Science and Technology, NTNU, in Trondheim. He has been a post doc/visiting scholar at Glasgow University, UK, at UCLA Los Angeles, with Donald Cram at MIT Cambridge, USA, with Alexander Klibanov and at Cytel Corporation, San Diego. He has led the biocatalysis group at NTNU whose research focused on synthesis of enantiopure compounds directed towards production of chiral drugs. In 2001 he initiated COST action D25, Applied Biocatalysis, which he also chaired from beginning to end. Professor Anthonsen′s primary research interests are natural product chemistry and biocatalysis in organic chemistry.

Okładka tylna:
This reference covers the wide and rapidly growing field of biocatalysis. It combines complementary expertise from such areas as microbiology, enzymology, molecular biology, structural biology and organic chemistry, this highlighting the interdisciplinary nature of the subject. With its special focus on progress and new developments towards environmentally beneficial reactions with high levels of selectivity for the production of key compound classes, this book will enlighten both chemists and biologists as to the advances and opportunities existing in enzyme catalysis.