Asymmetric Synthesis of Nitrogen Heterocycles

Long awaited and truly needed –– the only book to focus on this hot topic.
Heterocycles play an important role in our every day life. Vitamins, hormones, antibiotics, pharmaceuticals, dyes and other products contain heterocycles, such that every organic chemist needs to know the chemistry of this substance class. Asymmetric synthesis in particular is a challenging field in today′s synthetic chemistry.
Here, all aspects of the topic are presented in a compact manner, written by an international team of authors who provide important experimental procedures, including industrial applications.
This monograph is clearly structured and divided into two sections –– asymmetric synthesis of heterocycles containing only one nitrogen and that of those with more than one nitrogen as a heteroatom. This means that the necessary information may be found at a glance.
Essential for synthetic chemists in pharmaceutical and agrochemical chemistry, as well as organic and medicinal chemists, as well as those working with/on organometallics.

Spis treści:
Preface.
List of Contributors.
Part One: Asymmetric Synthesis of Nitrogen Heterocycles Containing Only One Heteroatom.
1 Asymmetric Synthesis of Three– and Four–Membered Ring Heterocycles (Giuliana Cardillo, Luca Gentilucci and Alessandra Tolomelli).
1.1 Substituted Aziridines.
1.2 Substituted Monocyclic Azetidines and Carbocyclic–Fused systems.
References.
2 Asymmetric Synthesis of Five–Membered Ring Heterocycles (Pei–Qiang Huang).
2.1 Monocyclic Pyrrolidines and Pyrrolidinones.
2.2 Pyrrolines.
2.3 Fused Bicyclic Systems with Bridgehead Nitrogen.
2.4 Acknowledgments.
References.
3 Asymmetric Synthesis of Six–Membered Ring Heterocycles (Naoki Toyooka).
3.1 Introduction.
3.2 Dihydropyridines.
3.3 Tetrahydropyridines .
3.4 Monocyclic Piperidines and Carbocyclic Fused Systems.
3.5 Fused Tri– or Bicyclic System with Bridgehead Nitrogen.
References.
4 Asymmetric Synthesis of Seven– and More–Membered Ring Heterocycles (Yves Troin and Marie–Eve Sinibaldi).
4.1 Substituted Azepines.
4.2 Substituted Azocines.
4.3 Substituted Large Nitrogen–Containing Rings.
References.
Part Two: Asymmetric Synthesis of Nitrogen Heterocycles with More Than One Heteroatom.
5 Asymmetric Synthesis of Three– and Four–Membered Ring Heterocycles with More Than One Heteroatom (Steve Lanners and Gilles Hanquet).
5.1 Introduction.
5.2 Three–Membered N–Heterocycles with Two Heteroatoms.
5.3 Four–Membered N–Heterocycles with Two Heteroatoms.
5.4 Conclusions.
References.
6 Asymmetric Synthesis of Five–Membered Ring Heterocycles with More Than One Heteroatom (Catherine Kadouri–Puchot and Claude Agami).
6.1 Five–Membered Heterocycles with N and O Atoms.
6.2 Five–Membered Heterocycles with Two N Atoms.
6.3 Five–Membered Heterocycles with N and S Atoms.
References.
7 Asymmetric Synthesis of Six–Membered Ring Nitrogen Heterocycles with More Than One Heteroatom (Péter Mátyus and Pál Tapolcsányi).
7.1 Six–Membered Rings with Another Heteroatom in the Same Ring.
References.
8 Asymmetric Synthesis of Seven–Membered Rings with More Than One Heteroatom (Jacques Royer).
8.1 Diazepines.
8.2 Oxazepines.
8.3 Thiazepines.
References.
Index.

Nota biograficzna:
Jacques Royer is Director of Research at the CNRS. He is currently the head of a laboratory of medicinal chemistry at the University Paris Descartes. He got his PhD at the University of Paris–Sud Orsay, and worked for 18 years at the Institut de Chimie des Substances Naturelles at the CNRS in Gif–sur–Yvette in the group of Prof. Henri–Philippe Husson. His research areas are asymmetric synthesis of natural products and more particularly alkaloids, amino alcohols and amino acids as well as original methods of synthesis including electrosynthesis. He is the author of about 100 publications in international renowned journals.

Okładka tylna:
Long awaited and truly needed –– the only book to focus on this hot topic.
Heterocycles play an important role in our every day life. Vitamins, hormones, antibiotics, pharmaceuticals, dyes and other products contain heterocycles, such that every organic chemist needs to know the chemistry of this substance class. Asymmetric synthesis in particular is a challenging field in today′s synthetic chemistry.
Here, all aspects of the topic are presented in a compact manner, written by an international team of authors who provide important experimental procedures, including industrial applications.
This monograph is clearly structured and divided into two sections –– asymmetric synthesis of heterocycles containing only one nitrogen and that of those with more than one nitrogen as a heteroatom. This means that the necessary information may be found at a glance.
Essential for synthetic chemists in pharmaceutical and agrochemical chemistry, as well as organic and medicinal chemists, as well as those working with/on organometallics.