Design and Strategy in Organic Synthesis: From the Chiron Approach to Catalysis

This long–awaited graduate level textbook adopts a refreshingly unique approach, and is written by one of the world′s leading organic chemists.
Following an introductory look at the concept of synthesis, the text goes on to discuss sources of enantiomerically pure compounds, the Chiron approach, locating the various substructures, synthesis with the various precursors and computer–aided synthesis. The whole is rounded off by an appendix with selected transformations of amino acids, carbohydrates, hydroxyacids and terpenes.
A must–have source of first–class information for everyone working in organic synthesis, not only for graduate students.

Spis treści:
The Concept of Synthesis
The "Why" of Synthesis
The "What" of Synthesis
The "How" of Synthesis
Sources of Enantiomerically Pure Compounds
The Chiron Approach
In Search of Chirons
Locating Amino Acid Substructures
Locating Carbohydrate Substructures
Locating Hydroxy Acid Substructures
Locating Terpenes Substructures
Locating Carbocycles and Lactone Substructures
Synthesis with Amino Acid Precursors
Synthesis with Carbohydrates Precursors
Synthesis with Hydroxy Acids
Synthesis with Terpenes Precursors
Synthesis with Carbocyclic Precursors
Synthesis with Lactone Precursors
Computer–aided Synthesis –
The Chiron Program
Appendix–Selected transformation of amino acids, carbohydrates, hydroxyacids and terpenes


Nota biograficzna:
Stephen Hanessian is the Achaogen Research Chairholder at the University of Montreal and an Adjunct Professor of Chemistry and Chemical Biology at the University of California, Irvine. He has received several awards, e.g. the A. C. Cope Scholar Award, the Queen Elisabeth Golden Jubilee Medal and many others. His research interests span a wide cross–section of areas related to organic, bioorganic, and medicinal chemistry.
Simon Girou x joined the Hanessian group as a Ph.D. student and he is currently an NSERC Postdoctoral Fellow at Harvard University with Prof. E. J. Corey.