Modern Gold Catalyzed Synthesis

With its impressive features, gold has added another facet to organic catalysis. Focusing on homogeneous catalysis this book also covers the main applications in heterogeneous catalysis.
Following a look at the gold–catalyzed addition of heteroatom nucleophiles to alkynes, this monograph goes on to discuss gold–catalyzed additions to allenes and alkenes, gold–catalyzed benzannulations, cycloisomerization and rearrangement reactions, as well as oxidation and reduction reactions. The whole is finished off with a section on gold–catalyzed aldol and related reactions and the application of gold–catalyzed reactions to natural product synthesis.


Spis treści:
GOLD–CATALYZED ADDITION OF HETEROATOM NUCLEOPHILES TO ALKYNES
Gold–Alkyne Complexes
Hydrochlorination
Hydration
Hydroalkoxylation
Hydroamination
Hydrothiloation
Cyclization to Aromatic Heterocycles
GOLD–CATALYZED ADDITIONS TO ALLENES
Gold–Allene Complexes
O–Nucleophiles
N–Nucleophiles
S–Nucleophiles
GOLD–CATALYZED ADDITIONS TO ALKENES
Gold–Alkene Complexes
O–Nucleophiles
N–Nucleophiles
GOLD–CATALYZED BENZANNULATIONS
GOLD–CATALYZED CYCLOISOMERIZATION AND REARRANGEMENT REACTIONS
Enyne Cyclization and Related Cycloisomerizations
Rearrangement of Propargyl Esters, Amides and Related Substrates
Sigmatropic Rearrangements
GOLD–CATALYZED OXIDATION REACTIONS
Oxidation of Alkenes
Oxidation of Alcohols
GOLD–CATALYZED REDUCTION REACTIONS
Hydrogenation of C–C Multiple Bonds
Reduction of C–O Double Bonds
Reduction of Nitro Compounds
GOLD–CATALYZED ALDOL AND RELATED REACTIONS
Aldol Reactions
Mannich Reactions
Michael Additions
APPLICATION OF GOLD–CATALYZED REACTIONS TO NATURAL PRODUCT SYNTHESIS

Nota biograficzna:
Dean Toste received his B.Sc. and M.Sc. degrees in chemistry from the University of Toronto and his PhD from Stanford University with Professor Barry M. Trost. Following postdoctoral studies with Professor Robert H. Grubbs at Caltech, he joined the faculty at the University of California, Berkeley in July of 2002, where he is currently the Chevron Assistant Professor of Chemistry. Since arriving at Berkeley, Professor Toste has been the recipient of numerous awards, including an A.P. Sloan Research Fellowship and a Cope Scholar Award from the American Chemical Society.
Stephen Hashmi is professor for Organic Chemistry at Universität Stuttgart, Germany. He obtained his academic degrees from Ludwig–Maximilians–Universität München, after his postdoctoral studies with Barry M. Trost at Stanford University he started his Habilitation at Freie Universität Berlin with Johann Mulzer. During that time he followed Prof. Mulzer to Johann Wolfgang Goethe–Universität Franfurt and Universität Wien. He then returned to Frankfurt to finish his Habilitation. After the stations University of Tasmania, Australia, and Universität Marburg he was appointed a permanent position at Universität Stuttgart. He has authored over 100 scientific publications and received a Karl–Ziegler fellowship and the ORCHEM–price for natural scientists.