Modern Alkaloids: Structure, Isolation, Synthesis, and Biology

This book presents all important aspects of modern alkaloid chemistry, making it the only work of its kind to offer up–to–date and comprehensive coverage. Concentrating initially on the structure and biology of bioactive alkaloids, the book then analyses new trends in alkaloid isolation and structure elucidation, progressing to the synthesis and biosynthesis of alkaloids.
A must for biochemists, organic, natural products, and medicinal chemists, as well as pharmacologists, pharmaceutists, and those working in the pharmaceutical industry.

Spis treści:
Preface.
List of Contributors.
I: BIOACTIVE ALKALOIDS: STRUCTURE AND BIOLOGY.
1. Ecological Roles of Alkaloids (Michael Wink).
2. Antitumor Alkaloids in Clinical Use or in Clinical Trials (Muriel Cuendet and John M. Pezzuto).
3. Alkaloids and the Bitter Taste (Angela Bassoli, Gigliola and Gilberto Busnelli).
4. Capsaicin and Capsaicinoids(Giovanni Appendino).
5. Glycosidase–Inhibiting Alkaloids: Isolation, Structure, and Application (Naoki Asano).
6. Neurotoxic Alkaloids from Cyanobacteria (Rashel V. Grindberg, Cynthia F. Shuman, Carla M. Sorrels, Josh Wingerd and William H. Gerwick).
7. Lamellarin Alkaloids: Structure and Pharmacological Properties (Jérôme Kluza, Philippe Marchetti and Christian Bailly).
8. Manzamine Alkaloids (Jiangnan Peng, Karumanchi V. Yeun–Mun Choo and Mark T. Hamann).
9. Antiangiogenic Alkaloids from Marine Organisms (Ana R. Diaz–Marrero, Christopher A. Gray, Lianne McHardy, Kaoru Warabi, Michel Roberge and Raymond J. Andersen).
10. A Typical Class of Marine Alkaloids: Bromopyrroles (Anna Aiello, Ernesto Fattorusso, Marialuisa Menna and Orazio Taglialatela–Scafati).
11. Guanidine Alkaloids from Marine Invertebrates (Roberto G. S. Berlinck and Miriam H. Kossuga).
II: NEW TRENDS IN ALKALOID ISOLATION AND STRUCTURE ELUCIDATION.
12. Analysis of Tropane Alkaloid s in Biological Matrices (Philippe Christen, Stegan Bieri and Jean–Luc Veuthey).
13. LC–MS of Alkaloids: Qualitative Profiling, Quantitative Analysis, and Structural Identification (Steven M. Colegate and Dale R. Gardner).
14. Applications of 15NNMR Spectroscopy in Alkaloid Chemistry (Gary E. Martin, Marina Solntseva and Antony J. Williams).
III: NEW TRENDS IN ALKALOID SYNTHESIS AND BIOSYNTHESIS.
15. Synthesis of Alkaloids by Transition Metal–Mediated Oxidative Cyclizations (Hans–Joachim Knölker).
16. Camptothecin and Analoges: Structure and Synthetic Efforts (Sabrina Dallavalle and Lucio Merlini).
17. Combinatorial Synthesis of Alkaloid–like Compounds In Search of Chemical Probes of Protein–Protein Interactions (Michael Prakesch, Prabhat Arya, Marwen Naim, Traian Sulea, Enrico Purisima, Aleksey Yu. Denisov, Kalle Gehring, Trina L. Foster and Robert G. Korneluk).
18. Daphniphyllum alkaloids: Structures, Biogenesis, and Activities (Hiroshi Morita and Jun′ichi Kobayashi).
19. Structure and Biosynthesis of Halogenated Alkaloids (Gordon W. Gribble).
20. Engineering Biosynthetic Pathways to Generate Indolocarbazole Alkaloids in Microorganisms (César Sánchez, Carmen Méndez and José A. Salas).
Index.

Nota biograficzna:
Ernesto Fattorusso is Professor of Organic Chemistry at the Faculty of Pharmacy of the University of Naples "Federico II", where he has twice been elected Dean. He has won the "A. Quilico Award" of the Società Chimica Italiana and the "P. Scheuer Award" of the Akademie of Erfurt. The focus of his scientific activity is on the structure and biogenesis of melanins, as well as the chemistry of bioactive metabolites from marine organisms and from Mediterranean flora. Prof Fattorusso has more than 300 research papers and 9 patents to his name.
Orazio Taglialatela Scafati is Ass ociate Professor in Organic Chemistry, Faculty of Pharmacy, University of Naples "Federico II". He got the Ph.D. in "Bioactive Natural Products " in 1997, under the supervision of Prof. Fattorusso. His research interests deal with isolation, structure elucidation and semisynthetic transformations of bioactive secondary metabolites from marine invertebrates and terrestrial plants. Prof. Taglialatela Scafati is author of more than 50 research papers, two patents and is the editor of the book "Flavour and Fragrance Chemistry".

Okładka tylna:
This book presents all important aspects of modern alkaloid chemistry, making it the only work of its kind to offer up–to–date and comprehensive coverage. Concentrating initially on the structure and biology of bioactive alkaloids, the book then analyses new trends in alkaloid isolation and structure elucidation, progressing to the synthesis and biosynthesis of alkaloids.
A must for biochemists, organic, natural products, and medicinal chemists, as well as pharmacologists, pharmaceutists, and those working in the pharmaceutical industry.