Proteomics in Drug Research

By delving beyond the genomic information, proteomics can address problems that are inaccessible to conventional genomics studies. These new and powerful analytical techniques open up new possibilities for the investigation of drug action and for the development of new drugs.
From skillful handling of the wide range of technologies to successful applications in drug discovery –– this handbook has all the information professional proteomics users need.
Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field.
Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein–protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer′s disease, neuroproteomics, plasma and T–cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics.
With its coverage of a wide range of technologies and areas of application, this book is invaluable for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.

INTRODUCTION
Administrative Optimization of Proteomics Networks for Drug Development
Proteomic Data Standardization, Deposition and Exchange
PROTEOMIC TECHNOLOGIES
Difference Gel Electrophoresis (DIGE): the Next Generation of Two–Dimensional Gel Electrophoresis for Clinical Research
Biological Mass Spectrometry: Basics and Drug Discovery Related Approaches
Multidimensional Column Liquid Chromatography (LC) in Proteomics
Peptidomics Technologies and Applications in Drug Research
Protein Biochips in the Proteomic Field
Current Developments for the In Vitro Characterization of Protein Interactions
APPLICATIONS
Molecular Networks in Morphologically Intact Cells and Tissue–Challenge for Biology and Drug Development
From Target to Lead Synthesis
Differential Phosphoproteome Analysis in Medical Research
Biomarker Discovery in Renal Cell Carcinoma Applying Proteome–Based Studies in Combination with Serology
Studies of Drug Resistance Using Organelle Proteomics
Clinical Neuroproteomics of Human Body Fluids: CSF and Blood Assays for Early and Differential Diagnosis of Dementia
Proteomics in Alzheimer′s Disease
Cardiac Proteomics
Innovation Processes

All six editors are Researchers at the Medical Proteom–Center hosted by the University of Bochum (Germany). This international research center was established in 2002 under the leadership of Helmut E. Meyer, a co–founder of the Protagen AG. Professor Meyer is also initiator and coordinator of the Human Brain Proteome Project within the German National Genome Research Net (NGFN) as well as of the Brain Proteome Project within the Human Proteome Organisation (HUPO BPP).

"The scope is broad, encompassing administrative, scientific, and marketing components .this book can certainly find a place in the library of any organization that makes use of proteomics." ( Journal of Medicinal Chemistry, December 14, 2006)