Modular Protein Domains

The definitive reference on protein modules covers all relevant modular domains mediating protein–protein interactions:SH2, SH3, WW domainsEVH1 and GYF domainsPTB and FHA domainsProtein kinase domainsSET, Bromo and Chromo domainsPDZ and EH domainsUbiquitin– and actin–binding domainsPhosphoinositide–binding domains
Structure, function and interaction partners of the domains are systematically treated, a general section covers methods to study protein–protein interactions on a proteome–wide scale.

Spis treści:
Preface.
List of Contributors.
Prologue: An Overview of Protein Modular Domains as Adaptors (Sir Tom L. Blundell).
1 The SH2 Domain: a Prototype for Protein Interaction Modules (Tony Pawson, Gerald D. Gish, and Piers Nash).
1.1 The Multidomain Nature of Signaling Proteins and Identification of the SH2 Domain.
1.2 SH2 Domains as a Prototype for Interaction Domains.
1.3 Structure and Binding Properties of SH2 Domains.
1.4 Different Modes of SH2 Domain–Phosphopeptide Recognition.
1.5 Signaling Pathways and Networks.
1.6 Plasticity of SH2 Domains.
1.7 SH2 Domain Dimerization.
1.8 Tandem SH2 Domains.
1.9 Composite and Complex Interaction Domains.
1.10 Allosteric Regulation.
1.11 SH2 Domains and Disease.
1.12 Summary.
References.
2 SH3 Domains (Bruce J. Mayer and Kalle Saksela).
2.1 Brief Overview.
2.2 Historical Perspective.
2.3 Predicting Binding Partners.
2.4 Experimental Exploitation of SH3 Specificity.
2.5 Conclusion.
References.
3 The WW Domain (Marius Sudol).
3.1 Introduction and Brief History of Module Discovery.
3.2 Structure of the WW Domain–Ligand Complex.
3.3 WW Domains and Human Diseases.
3.4 Emerging Directions and Recent Developments.
3.5 Concluding Remarks.< br>References.
4 EVH1/WH1 Domains (Linda J. Ball, Urs Wiedemann, Jürgen Zimmermann, and Thomas Jarchau).
4.1 Introduction.
4.2 Occurrence and Distribution of EVH1 Domains.
4.3 Structures of EVH1 Domains and Their Complexes.
4.4 Biological Function and Signaling Pathways Involving EVH1 Domains.
4.5 Emerging Research Directions and Recent Developments.
4.6 Concluding Remarks.
References.
5 The GYF Domain (Christian Freund).
5.1 Introduction.
5.2 Structure of the CD2BP2–GYF Domain and Its Interaction with the CD2 Signaling Peptide SHRPPPPGHRV.
5.3 Molecular and Signaling Function of GYF Domains.
5.4 Emerging Research Directions and Recent Developments.
5.5 Concluding Remarks.
References.
6 PTB Domains (Ben Margolis and Linton M. Traub).
6.1 Introduction.
6.2 Function of PTB Domain Proteins.
6.3 PTB Domain Structure.
6.4 Conclusions.
References.
7 The FHA Domain (Daniel Durocher).
7.1 Introduction.
7.2 FHA Domain Structure.
7.3 Molecular and Signaling Function.
7.4 Emerging Research Direction.
7.5 Concluding Remarks.
References.
8 Phosphoserine/Threonine Binding Domains (Andrew E. H. Elia and Michael B. Yaffe).
8.1 Introduction.
8.2 The 14–3–3 Proteins.
8.3 WW Domains.
8.4 FHA Domains.
8.5 WD40 Repeats of F–box Proteins.
8.6 Polo–box Domains.
8.7 Conclusions and Future Directions.
References.
9 The Eukaryotic Protein Kinase Domain (Arvin C. Dar, Leanne E. Wybenga–Groot, and Frank Sicheri).
9.1 Introduction.
9.2 Architecture of the Kinase Domain.
9.3 Catalytic Switching Mechanisms.
9.4 Protein Kinase Substrate Recognition.
9.5 Conclusions.
References.
10 Structure, Specificity, and Mechanism of Protein Lysine Methylation b y SET Domain Enzymes (James H. Hurley and Raymond C. Trievel).
10.1 Discovery and Biology of SET Domains.
10.2 Structure of the SET Domain.
10.3 Substrate Specificity and Catalytic Mechanism.
10.4 Emerging Directions and Conclusions.
References.
11 The Structure and Function of the Bromodomain (Kelley S. Yan and Ming–Ming Zhou).
11.1 Introduction.
11.2 The Bromodomain Structure.
11.3 The Bromodomain as an Acetyl–lysine Binding Domain.
11.4 Emerging Developments.
11.5 Concluding Remarks.
References.
12 Chromo and Chromo Shadow Domains (Joel C. Eissenberg and Sepideh Khorasanizadeh).
12.1 Introduction and Brief History of the Module’s Discovery.
12.2 Structures of the Chromo and Chromo Shadow Domains.
12.3 Function of the Chromo Domain.
12.4 Genetic, Cytological, and Molecular Properties of the Chromo Domain.
12.5 Emerging Research Directions and Recent Developments.
References.
13 PDZ Domains: Intracellular Mediators of Carboxy–terminal Protein Recognition and Scaffolding (Laurence A. Lasky, Nicholas J. Skelton, and Sachdev S. Sidhu).
13.1 Introduction.
13.2 Structural Analysis of PDZ Domains.
13.3 Analysis of PDZ Domain–Ligand Interactions with Mutagenesis and Synthetic Peptides.
13.4 Molecular and Signaling Functions of PDZ Domains.
13.5 Concluding Remarks.
References.
14 EH Domains and Their Ligands (Brian K. Kay, Michael D. Scholle, and Fred J. Stevens).
14.1 Introduction.
14.2 EH Domain–containing Proteins.
14.3 Peptide Ligands.
14.4 Cellular Ligands.
14.5 Structures of the Domain and Its Ligands.
14.6 Evolutionary Origins of the EH Domain.
14.7 Functions of the EH Domain.
References.
15 Ubiquitin Binding Modules: The Ubiquitin Network Beyond the Proteasome (Stefano Co nfalonieri and Pier Paolo Di Fiore).
15.1 Introduction: The Ubiquitin System in Proteolysis and Beyond.
15.2 CUE and UBA Domains.
15.3 The Ubiquitin–interacting Motif.
15.4 The UEV Domain.
15.5 The PAZ and NZF Domains.
15.6 Ubiquitin–based Networks.
15.7 Conclusions.
References.
16 The Calponin Homology (CH) Domain (Mario Gimona and Steven J. Winder).
16.1 Introduction and Brief History.
16.2 Structure of the Domain – The CH Domain Fold.
16.3 Molecular and Signaling Function.
16.4 Emerging Research Directions and Recent Developments.
16.5 Concluding Remarks.
References.
17 PH Domains (Mark A. Lemmon and David Keleti).
17.1 Introduction.
17.2 PH Domain Structure and Phosphoinositide Binding.
17.3 Molecular and Signaling Function of PH Domains.
17.4 Emerging Research Directions and Recent Developments.
References.
18 ENTH and VHS Domains (Vimal Parkash, Olli Lohi, Ismo Virtanen, and Veli–Pekka Lehto).
18.1 Introduction.
18.2 History of ENTH.
18.3 Structure of ENTH Domains.
18.4 Signaling and Molecular Functions of ENTH.
18.5 History of VHS.
18.6 Structure of VHS Domains.
18.7 Function of GGA–VHS Domains.
18.8 Function of Non–GGA VHS Domains.
18.9 Involvement of ENTH and VHS Domains in Human Disease.
18.10 Emerging Research Directions.
18.11 Concluding Remarks.
References.
19 PX Domains (Matthew L. Cheever and Michael Overduin).
19.1 Introduction and History of the PX Domain Discovery.
19.2 Structure of the PX Domain.
19.3 Biological Function of the PX Domain.
19.4 Emerging Research Directions and Recent Developments.
References.
20 Peptide and Protein Repertoires for Global Analysis of Modules (Krzysztof Bialek, Andrzej Swistowski, and Ronald Frank).
20.1 Introductio