Medicinal Chemistry: Fundamentals

After the definition and the cycle of the life of drugs, the physico-chemical properties of these compounds and the consequences in the development to obtain a drug are described. The fundamental concepts of Medicinal Chemistry (pharmacophore, prodrugs, Lipinsky rules) are studied in this book. Finally, the book studies that which concerns the European Pharmacopeia - "the industrialist’s bible" - its role and the description of the monographs of the active principles.

Defines the life cycle of drugsExplains the physico-chemical properties, consequences of a drugStudies the fundamental concepts of medicinal chemistryDescribes the active ingredient monographs

1. Medicines and Drugs 2. Importance and Evaluation of the pKa 3. Importance and Evaluation of Lipophilicity 4. Importance and Evaluation of Solubility 5. Importance and Evaluation of the Polar Surface Area (PSA and TPSA) 6. Lipinski’s Rule of Five 7. Principle of a Prodrug 8. Pharmacophore 9. The European Pharmacopoeia