Bioreactor Modeling: Interactions between Hydrodynamics and Biology

Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand, have the ability to modulate the rate of substrate assimilation. Moreover, the nature of the biochemical transformations results from a compromise between the needs of the cell and the available resources. This book revisits the modeling of bioreactors using a multi-scale approach. It addresses issues related to mixing, phase-to-phase transfers and the adaptation of microorganisms to variations in concentration, and explores the use of population balances for the simulation of bioreactors. By adopting a multidisciplinary perspective that draws on process engineering, fluid mechanics and microbiology, this book sheds new light on the particularity of bioprocesses in relation to physical and chemical phenomena.

Presents a multiphase description of bioreactor modelingIncludes a combination of concepts issued from different scientific fields to address a practical issueProvides a detailed description of the population balance concept as applied to biological systemsCovers a set of illustrative examples of the interaction between hydrodynamics and biological response

1. Basic Concepts for Bioreactor Modelling 2. Mixing, Transfer and Reaction 3. Flow Characterization and Particle Trajectory 4. From Average Cell to Population Balance Approach 5. Mechanical Interactions