Immunology of Diabetes V: From Bench to Bedside, Volume 1149

This volume an overview of current research in the field of immunology as it relates to diabetes. Topics covered include: autoantibody markers for type 1 diabetes; cellular immune markers for type 1 diabetes; animal models of type 1 diabetes; the pancreas in type 1 diabetes; genetics of type 1 diabetes; the role of toll–like receptors and innate immunity in type 1 diabetes; cell–based therapies for type 1 diabetes; environmental and mechanistic causes of type 1 diabetes; mechanisms of beta–cell death; role of the immune response in type 1 diabetes; and islet transplantation.
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Spis treści:
Preface: C.B. Sanjeevi.
Part I: Special Reports:.
1. The Environmental Determinants of Diabetes in the Young (TEDDY) Study: The TEDDY Study Group and Marian Rewers.
2. Type 1 Diabetes TrialNet – An International Collaborative Clinical Trials Network: Jay S. Skyler, Carla J. Greenbaum, John M. Lachin, Ellen Leschek, Lisa Rafkin–Mervis, Peter Savage, Lisa Spain, and the Type 1 Diabetes TrialNet Study Group.
3. What will it Take to get Therapies Approved for Type 1 Diabetes?: Alexander Flemming.
Part II: The Pancreas in Type 1 Diabetes:.
4. Islet Glia, Neurons and β–cells: The Neuroimmune–Interface in Type 1 Diabetes Pathogenesis: Hubert Tsui, Shawn Winer, Yin Chan, Dorothy Truong, Lan Tang, Jason Yantha, Geoffrey Paltser, and Hans–Michael Dosch.
5. Hedgehog signalling during expansion of human Pancreatic Islet–Derived precursors: Rita Gallo, Fabio Arturo Grieco, Lorella Marselli, Elisabetta Ferretti, Alberto Gulino, Piero Marchetti and Francesco Dotta.
Part III: Update on Animal Models of Type 1 Diabetes:.
6. Humanized Mice for the Study of Type 1 Diabetes and Beta Cell Function: Marie King, Todd Pearson, Aldo A. Rossini, Leonard D. Shultz, and Dale L. Greiner.
7. Developing a Novel Model System to Target Insulin Reactive CD8 T Cells: Gwen S. Scott, Sigal Fishman, Alon Margalit, L. Khai Siew, Stephen Chapman, Li Wen, Gideon Gross, and F. Susan Wong.
8. GATA–2 Gene (Chr6、38.5cM) Locates Close to Idd20 (Chr6、37.7cM): Lowered Expressions of the NF–κB Family Members in Dendritic Cells from NOD Mice are Associated with a Reduced Expression of GATA–2: Kazuma Takahashi, Jo Satoh, and Yoshitomo Oka.
9. Measurement of CD8+ T–Cell Responses in Human Type 1 Diabetes: Emanuela Martinuzzi, François A. Lemonnier, Christian Boitard, and Roberto Mallone.
10. Comparative Analysis of the Islet Proteome Between NOD/Lt and ALR/Lt Mice: Ping Yang, Manyu Li, Dehuang Guo, Feili Gong, Bao–Ling Adam, Mark A. Atkinson and Cong–Yi Wang.
Part IV: Genetics of Type 1 Diabetes: The Next Generation:.
11. MicroRNA Genes: Are They Susceptibility Candidates for Human Type 1 Diabetes?: Li Zhou, Hongzhi He, Jenny X. Mi, Changgui Lia, Byung Lee, and Qing–Sheng Mi.
12. Independent Association of Tumor Necrosis Factor Polymorphism with Type 1 Diabetes Susceptibility: Hyoung Doo Shin, Sei Won Yang, Duk Hee Kim, and Yongsoo Park.
13. HLA Class I Supertypes in Type 1 Diabetic Children in an Urban Children’s Hospital: Zoltan Antal, Irene Jarchum, and Teresa P. DiLorenzo.
14. Congenic Mapping of the MHC–Linked Susceptibility to Type 1 Diabetes in the NOD Mouse: at Least Two Genes Contribute to the Idd16 Effect: Yoshihisa Hiromine, Tomomi Fujisawa, Shinsuke Noso, Naru Babaya, Yumiko Kawabata, and Hiroshi Ikegami.
15. STAT4 Polymorphism is Associated with Early–onset Type 1 Diabetes, but not with Late–onset Type 1 Diabetes: Hye–Soon Lee, Hyewon Park, Seiwon Yang, Dukhee Kim, and Yongsoo Park.
16. From Type 1, LADA to Type 2 Diabetes: A Continuous Spectrum? The Evidence of HLA–DQ Gene: J. Lin, Z.G. Zhou, J.P. Wang, C. Zhang, and G. Huang.
17. Molecular Scanning of the Gene for Thioredoxin, an Antioxidative and Antiapoptotic Protein, and Genetic Susceptibility to Type 1 Diabetes: Hiroshi Ikegami, Masaya Ono, Tomomi Fujisawa, Yoshihisa Hiromine, Yumiko Kawabata, and Eiji Yamato.
18. The Risk Conferred by HLA–DR and DQ for Type 1 Diabetes in 0–35 Years Age Group is not Uniform and are Different in Different Regions of Sweden: Carani B. Sanjeevi, Saikiran K Sedimbi, Mona Landin–Olsson , Ingrid Kockum, Åke Lernmark on behalf of the Swedish Childhood Diabetes and the Diabetes Incidence in Sweden Study Groups.
Part V: Toll–like Receptors and Innate Immunity in Type 1 Diabetes:.
19. The Circle between the Bedside and the Bench: Toll–Like Receptors in Models of Viral Induced Diabetes: Rita Bortell, Steven C. Pino, Dale L. Greiner, Danny Zipris, and Aldo A. Rossini.
20. Toll–like Receptors and Diabetes: F. Susan Wong and Li Wen.
21. Different KIRs Confer Susceptibility and Protection to Latent Autoimmune Diabetes in Adults in Latvian and Asian–Indian Populations: Arun Shastry, Saikiran K Sedimbi, Raja Rajalingam, Ingrida Rumba, Alok Kanungo, and CB Sanjeevi.
22. Innate Immune Pathways in Virus–Induced Autoimmune Diabetes: Anjali Nair, Travis R. Wolter, Adam J. Meyers, and Danny Zipris.
23. The Distribution of Adiponectin Receptors on Human Peripheral Blood Mononuclear Cells: Terence TL Pang and Parth Narendran.
24. The Role of Toll– ;Like Receptors 3 and 9 in the Development of Autoimmune Diabetes in NOD Mice: F. Susan Wong, Changyun Hu, Li Zhang, Wei Du, Lena Alexopoulou, Richard A Flavell, and Li Wen.
25. TLR Agonists Abrogate Costimulation Blockade–Induced Mixed Chimerism and Transplantation Tolerance: David M. Miller, Thomas Thornley, Todd Pearson, Masahiro Yamazaki, Michael A. Brehm, Aldo A. Rossini, and Dale L. Greiner.
Part VI: Prevention or Reversal of Type 1 Diabetes:.
26. Exendin–4 Therapy in New Onset NOD Mice Increases Regulatory T Cell Frequency: Song Xue, Clive H. Wasserfall, Matthew Parker, Todd M. Brusko, Sean McGrail, Kieran McGrail, Marcus Moore, Martha Campbell–Thompson, Desmond A. Schatz, Mark A. Atkinson, and Michael J. Haller.
27. Role of increased ROS dissipation in prevention of T1D: Lessons from the ALR mouse: Jing Chen, Aaron M Gusdon, Terri C Thayer, and Clayton E Mathews.
28. Apoptotic Non–β Cells Suppress β Cell Antigen–Reactive T Cells and Induce β Cell Antigen–Specific Regulatory T Cells: Transfusion of Apoptotic Splenic Stromal Cells Prevents Type 1 Diabetes: Chang–Qing Xia, Yushi Qiu, Ruihua Peng, Jeannette Lo–Dauer, and Michael J Clare–Salzler.
29. Persistence of Residual Beta Cells and Islet Autoimmunity During Increasing Duration of Diabetes in NOD Mice and Experimental Approaches Towards Reversing New–Onset Disease With Bioactive Peptides: Shiva Reddy, Carlos Chun Ho Cheung, Ryan Chau Chia Chai and Jessica Astrid Rodrigues.
30. TGF Plasmid Construction and Delivery for the Prevention of Type 1 Diabetes: Leejin Park, Eunjig Lee, Sangkyung Lee, Minsu Lim, Hekyung Hong, Geewook Shin, and Yongsoo Park.
31. Intravenous Administration of Murine Proinsulin1 or 2 Expressing Fiber–mutant Recombinant Adenovirus Vector Protects Diabetes in NOD Mice: Hiroaki Moriyama, Katsumi Yamada, Yasuyo Okumachi, Takashi Arai, Mami Kameno, Minoru Kishi, Hisafumi Yasuda, K