Drug Addiction: Research Frontiers and Treatment Advances, Volume 1120

This volume brings together basic and clinical science to provide in–depth understanding and current knowledge concerning new conceptual insights into the CNS acting drugs and drugs of abuse and treatment of drug addiction.
Methamphetamine, MDMA, PMA and different solvents are the most widely abused drugs in the Europe, United States, Central America, South America and Asian Countries and their use has dramatically increased over the last two decades. These drugs of abuse are known to cause neurotoxicity in several species including not only rodents, dogs and nonhuman primates, but also humans. However, precise neurochemical mechanisms underlying this drug–induced neurotoxicity remain unclear.
This volume addresses the following:
1) Role of Genomics, Proteomics and Metabonomics in Drug–induced Neurotoxicity
2) Drugs of Abuse and Medication Development
3) Molecular Biology and Free Radicals in Drugs of Abuse–induced neurotoxicity
4) Substituted Amphetamines–induced Neurochemical Changes and Relationship to Neurotoxicity
5) Drug of Abuse and Imaging Brain Structure and Function
6) GHB/Volatile Solvent/Inhalant Neurotoxicity
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Spis treści:
Part I: Gene Regulation and Drug Abuse:.
1. c–Fos Is an Intracellular Regulator of Cocaine–induced Long–term Changes: Ming Xu.
2. The Expression of NMDA Receptor Subunit mRNA in Human Chronic Alcoholics: Influence of Cirrhosis and Genotype: Justin P. Ridge, Ada M.–C. Ho, David J.Innes, and Peter R. Dodd.
3. Dopamine Receptor d4 Gene –521c/t polymorphism Is Associated with Opioid Dependence through Cold–Pain Responses: Ada M.–C. Ho, Nelson L.–S.Tang, Ben K.–L. Cheung, and Alfreda. Stadlin.
4. Injection of the Neuropeptide CNP into Dopaminergic Rat Brain Areas Decreases Alcohol Intake: Pascal Romieu, Serge Gobaille, Dominique Aunis, and Jean Zwiller.
5. Transcriptional Correlates of Human Substance Use: Elin Lehrmann and William J. Freed.
6. Association Study between Casein Kinase 1 Epsilon Gene and Methamphetamine Dependence: T. Kotaka, H. Ujike, Y. Morita, M. Kishimoto, Y. Okahisa, T. Inada, M. Harano, T. Komiyama, T. Hori, M. Yamada, Y. Sekine, N. Iwata, M. Iyo, I. Sora, N. Ozaki, and S. Kuroda.
7. Short Allele of 5–HTTLPR As a Risk Factor for the Development of Psychosis in Japanese Methamphetamine Abusers: Norikazu Ezaki, Kazuhiko Nakamura, Yoshimoto Sekine, Ismail Thanseem, Ayyappan Anitha, Yasuhide Iwata, Masayoshi Kawai, Kiyokazu Takebayashi, Katsuaki Suzuki, Nori Takei, Masaomi Iyo, Toshiya Inada, Nakao Iwata, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Hiroshi Ujike, and Norio Mori.
8. Association Study of the Calcineurin A Gamma Subunit Gene (PPP3CC) and Methamphetamine Use Disorder in the Japanese Population. A Collaborative Study by Japanese Genetics Iinitiative for Drug Abuse: Y. Kinoshita, M. Ikeda, H. Ujike, T. Kitajima, Y. Yamanouchi, B. Aleksic, T. Kishi, K. Kawashima, T. Ohkouchi, N. Ozaki, T. Inada, M. Harano, T. Komiyama, T. Hori, M. Yamada, Y. Sekine, M, Iyo, I. Sora, and N. Iwata.
9. Glutamate Cysteine Ligase Modifier (GCLM) Subunit Gene Not Associated with Methamphetamine Use Disorder and Schizophrenia in the Japanese Population: Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro K awashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Masaomi Iyo, Ichiro Sora, Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike, and Nakao Iwata.
10. No Association between Alpha4 and Beta2 Subunits of Neuronal Nicotinic Acetylcholine Receptor Genes and Methamphetamine Use Disorder in the Japanese Population: Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Masaomi Iyo, Ichiro Sora, Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike, and Nakao Iwata.
11. No Association between Prostate Apoptosis Response 4 Gene (PAWR) and Methamphetamine Use Disorder in the Japanese Population: Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Masaomi Iyo, Ichiro Sora, Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike, Nakao Iwata.
12. Transient Enhanced Expression of cdk5 Activator p25 after Acute and Chronic d–Amphetamine Administration: Estela Cecilia Mlewski, Favio Ariel Krapacher, Soledad Ferreras, and Gabriela Paglini.
13. Methamphetamine–induced Early Increase of IL–6 and TNF–α mRNA Expression in the Mice Brain: Joana Gonçalves, Tânia Martins, Raquel Ferreira, Nuno Milhazes, Fernanda Borges, Carlos Fontes Ribeiro, João O. Malva, Tice R. Macedo, and Ana P. Silva.
Part II: Substituted Amphetamine Neurotoxicity:.
14. Differential Response of Neurotensin to Methamphetamine Self–administration: Role of Contingency: Paul S. Frankel, Amanda J. Hoonakker, and Glen R. Hanson.
15. Dopamine Disposition in the Presynaptic Process Regulates the Severity of Methamphetamine–Induced Neurotoxicity: Donald M. Kuhn, Dina M. Francescutti–Verbeem, and David M. Thomas.
16. The Relative Importance of Dose, Hyperthermia, Seizures and the Blood Brain Barrier in the Brain Region Specific Neurodegenerative Profiles Induced by Amphetamine: John F. Bowyer, Monzy Thomas, Larry C. Schmued, and Syed Ali.
17. Sex Differences in Dopamine– and Vesicular Monoamine–transporter Functions: Implications for Methamphetamine Use and Neurotoxicity: D. E. Dluzen and J. L. McDermott.
18. Development and Characterization of a Novel Animal Model of Intermittent MDMA ("Ecstasy") Exposure During Adolescence: Jerrold S. Meyer, Brian J. Piper, and Valerie E. Vancollie.
19. Connection Between the Striatal Neurokinin–1 Receptor and Nitric Oxide Formation During Methamphetamine Exposure: Jing Wang, Wenjing Xu, Syed F. Ali, and Jesus A. Angulo.
20. The Agonist of M(1)–Muscarinic Acetylcholine Receptor Agonist Prevents Neurotoxicity Induced by Amphetamine Via Nitric Oxide Pathway: Valentina Bashkatova, Ariane Hornick, Anatoly Vanin, and Helmut Prast.
21. Pathways of Methamphetamine Toxicity: Effects of Autophagy and SOD Alteration in the Spinal Cord: Michela Ferrucci, Livia Pasquali, Antonio Paparelli, Stefano Ruggieri, and Francesco Fornai.
22. Analysis of Single, Purified Inclusions as a Novel Approach to Understand Methamphetamine Neurotoxicity: Paola Lenzi, Federica Fulceri, Gloria Lazzeri, Alessandro Casini, Stefano Ruggieri, Antonio Paparelli, and Francesco Fornai.
23. Role of Autophagy during Methamphetamine Neurotoxicity: Livia Pasquali, Gloria Lazzeri, Ciro Isidoro, Stefano Ruggieri, Antonio Paparelli, and Francesco Fornai.
24. Chronic Low Dose Oxidative Stress Induces Caspase–3 Dependent PKCδ Proteolytic Activation and Apoptosis in a Cell Culture Model of Dopaminergic Neurodegeneration: Martha Carvour, Chunjuan Song, Siddharth Kaul, Vellareddy Anantharam, Anumantha Kanthasamy, and Arthi Kanthasamy.
25. A Role for mGluR5 Receptors in Intravenous Methamphetamine Self–administration: Megan P.H. Osborne and M. Foster Olive.
26. Acute Increase of the