Autoimmunity, Part B: Novel Applications of Basic Research

The incidence of autoimmune diseases is increasing worldwide, and the search for better management of these diseases and even for a cure is being pursued by scientists from many disciplines. Tools from the areas of genetics, neuroscience, cell biology, virology, and infectious disease are being applied to the problem and are yielding useful results.
This is the second volume of a series of four on autoimmunity, and findings related to particular organs, organ systems, and diseases are presented. The focus in Part B is on genetics and advances in treatment. Part A presents new principles in autoimmunity and new diagnostic tools. See Parts C and D for clinical venues in autoimmunity.
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Spis treści:
Foreword: M. Eric Gershwin and Yehuda Shoenfeld.
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Part I: Genetics and Autoimmunity:.
1. Recent Advances in the Genetics of Autoimmune Diseases: Marta E. Alarcón–Riquelme.
2. Immunoglobulin–Like Transcripts as Risk Genes for Autoimmunity: Gamze Kabalak, Silke Koch, Baukje Dobberstein, Yu–Han The, Torsten Matthias, Sebastian Schnarr, Reinhold E. Schmidt, Torsten Witte.
3. Genetic Polymorphisms of Transforming Growth Factor Beta–1 Promoter and Primary Biliary Cirrhosis in Japanese Patients: Kentaro Kikuchi, Atsushi Tanaka, Masanao Matsushita, Eriko Kitazawa, Naomi Hosoya, Yumi Kawashima, Carlo Selmi, M. Eric Gershwin, Hiroshi Miyakawa.
4. Genetic Background of Anti–Cyclic Citrullinated Autoantibody Production in Hungarian Patients with Rheumatoid Arthritis: Gyula Poór, Zsolt B. Nagy, Zsuzsanna Schmidt, Márta Brózik, Katalin Merétey, Péter Gergely Jr.
5. Profiling Meta–Analysis Reveals Primarily Gene Co–Expression Concordance Between Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA): Guilherme L. Silva, Cristina M. Junta, Stephano S. Mello, Paula S. Garcia, Diane M. Rassi, Elza T. Sakamoto–Hojo, Eduardo A. Donadi, Geraldo A.S. Passos.
6. Role of the Interferon–Inducible Gene IFI16 in the Etiopathogenesis of Systemic Autoimmune Disorders: Michele Mondini, Matteo Vidali, Paolo Airò, Marco De Andrea, Piersandro Riboldi, Pier Luigi Meroni, Marisa Gariglio, Santo Landolfo.
7. The X Chromosome in Female Predominant Autoimmune Diseases: Pietro Invernizzi.
8. PolyI:C Induction of Diabetes is Controlled by Iddm4 in Rats with a Full Regulatory T–Cell Pool: Lars Hornum, Dorthe Lundsgaard, Helle Markholst.
9. Nitric Oxide Signaling Triggered by the Rheumatoid Arthritis Shared Epitope: A New Paradigm for MHC–Disease Association?: Joseph Holoshitz, Song Ling.
10. X Monosomy in Female Systemic Lupus Erythematosus: Pietro Invernizzi, Monica Miozzo, Sabine Oertelt–Prigione, Pier Luigi Meroni, Luca Persani, Carlo Selmi, Pier Maria Battezzati, Massimo Zuin, Simona Lucchi, Bianca Marasini, Silvana Zeni, Mitchell Watnik, Silvia Tabano, Silvia Maitz, Simone Pasini, M. Eric Gershwin, Mauro Podda.
11. MICA Gene Polymorphism in the Pathogenesis of Type 1 Diabets. By G. Gambelunghe, A. Brozzetti, M. Ghaderi, P. Candeloro, C. Tortoioli, A. Falorni.
12. Gene Vaccination for the Induction of Immune Tolerance: Francesca Ferrera, Antonio La Cava, Marta Rizzi, Bevra H. Hahn, Francesco Indiveri, Gilberto Filaci.
13. “B27 Disease” is a New Autoimmune Disease That Affects Millions of People: Alan Ebringer, Taha Rashid.
14. HCV–Related Disorders: Role of the HLA Class II: Valli De Re, Laura Caggiari, Maria Paola Simula, Salvatore De Vita, Cesare Mazzaro, Marco Lenzi, Massimo Galli M. Giuseppe Monti, Clodoveo Ferri, Anna Linda Zignego, Armando Gabrielli, Domenico Sansonno, Franco Dammacco, Massimo Libra, Nicoletta Sacchi, Renato Talamini, Michele Spina, Umberto Tirelli, Renato Cannizzaro, Riccardo Dolcetti.
15. A Genome–Wide Study of Lupus: Preliminary Analysis and Data Release: Alessandra C.L. Cervino, Nicholas F. Tsinoremas, Robert W. Hoffman.
16. Autoimmune Diabetes Mellitus with Adult Onset and Type 1 Diabetes Mellitus in Children Have Different Genetic Predispositions: Marie Cerna, Katarina Kolostova, Peter Novota, Marianna Romzova, Pavlina Cejkova, Daniela Pinterova, Stepanka Pruhova, Ludmila Treslova, Michal Andel.
17. Genetic Control of Immune Response in Carriers of the 8.1 Ancestral Haplotype: Correlation with Levels of IgG subclasses. Its Relevance in the Pathogenesis of Autoimmune Disease: Giuseppina Candore, Anna Maria Campagna, Irne Cuppari, Daniele Di Carlo, Claudia Mineo, Calogero Caruso.
18. Genetic Dissection of Autoimmune Polyendocrine Syndrome Type 2–Common Origin of a Spectrum of Phenotypes: Annalisa Ballarini, Min Ae Lee–Kirsch.
19. Association of the 5A/6A Promoter polymorphism of the MMP–3 Gene with the Radiographic Progression of Rheumatooid Arthritis: Petr Nemec, Monika Pavkova–Goldbergova, Jindra Gatterova, Anna Vasku, Miroslav Soucek.
20. Genotypic Approaches to Therapy in Children (GATC): A National Active Surveillance Network to Study the Pharmacogenomics of Severe Adverse Drug Reactions in Children: Colin J.D. Ross, Bruce Carleton, Dana G. Warn, Sunita B. Stenton, Shahrad Rod Rassekh, Michael R. Hayden.
21. Thyroid Epigenetics: X Chromosome Inactivation in Patients with Autoimmune Thyroid Disease: Xiaoming Yin, Rauf Latif, Yaron Tomer, Terry F. Davies.< br>22. Genetics and New Treatment Modalities for Familial Mediterranean Fever: Anupama Bhat, Stanley M. Naguwa, M. Eric Gershwin.
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Part II: Treatment:.
23. MMF (Mycophenolate Mofetil) and Atheroclerosis: Results of Animal and Human Studies: William Thomas Gibson , Michael Reuben Hayden.
24. T Cell Receptor Gene Therapy for Autoimmune Diseases. By Keishi Fujio, Tomohisa Okamura, Akiko Okamoto, Kazuhiko Yamamoto.
25. CD44 Involvement in Autoimmune Inflammations: The Lesson to be Learned from CD44–Targeting by Antibody or from Knock Out Mice: David Naor, Shlomo Nedvetzki, Marita Walmsley, Avner Yayon, Eva A. Turley, Ira Golan, Dan Caspi, Lora Eshkar Sebban, Yehiel Zick, Tali Garin, Dimitrios Karussis, Nathalie Assayag–Asherie, Itamar Raz, Lola Weiss, Shimon Slavin, Itshak Golan.
26. Efficacy of Intravenous Immunoglobulin in Multifocal Motor Neuropathy: Jean–Marc Leger, Steven Vargas, Isabelle Lievens.
27. New Autoantibodies in Paediatric Opsoclonus–Myoclonus Syndrome: A. Kirsten, S. Beck, V. Fühlhuber, M. Kaps, T. Kreutz, M. Korfei, S. Schmitt, K.T. Preissner, F. Blaes.
28. Current State of Biologicals in the Management of Systemic Vasculitis: Peter Lamprecht, Andreas Till, Jörg Steinmann, Peer M. Aries, Wolfgang L. Gross.
29. Interstitial Lung Disease Assocaited with Systemic Sclerosis: What is the Evidence for an Efficacy of Cyclophosphamide?: Alice Bérezné, Dominique Valeyre, Brigitte Ranque, Loïc Guillevin, Luc Mouthon.
30. Treatment of Autoimmune Disease with Rabbit Anti–T Lymphocyte Globulin (rATG): Clinical Efficacy and Potential Mechanisms of Action: Simon D. Lytton, Christopher P. Denton, Achim Nutzenberger.
31. Bromocriptine During Pregnancy in Systemic Lupus Erythematosus. A Pilot Clinical Trial: Luis J. Jara, Polita Cruz–Cruz, Miguel A. Saavedra, Gabriela Medina, Adriana Garciá–Flores, Ulises Angeles, Juan M. Miranda–Limòn.
32. Eff