Autoimmunity, Part D: Autoimmune Disease, Annus Mirabilis, Volume 1108

The incidence of autoimmune diseases is increasing worldwide, and the search for better management of these diseases and even for a cure is being pursued by scientists from many disciplines. Tools from the areas of genetics, neuroscience, cell biology, virology, and infectious disease are being applied to the problem and are yielding useful results.
This is the fourth and final volume of a series on autoimmunity, and findings related to particular clinical manifestations are presented, particularly systemic lupus erythematosus, scleroderma, rheumatoid arthritis, Sjogren′s syndrome, antiphospholipid antibodies, and infections and autoantibodies.
Part A presents new principles in autoimmunity and new diagnostic tools; Part B focuses on genetics and advances in treatment; and Part C begins the focus on the clinical venue.
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Spis treści:
Foreword: Yehuda Shoenfeld and M. Eric Gershwin.
Part I: Systemic Lupus Erythematosus:.
1. Glomerular Targets for Autoantibodies in Lupus Nephritis – An Apoptotic Origin: Svetlana N. Zykova, Natalya E. Seredkina, Ole Petter Rekvig.
2. Type I IFN Inhibition of Inflammatory Th Cell Responses in SLE: Alyson J. Mangini, Robert Lafyatis, Jean Maguire van Seventer.
3. Vascular Elasticity of Systemic Lupus Erythematosis Patients is Associated with Steroids and Hydroxychloroquine Treatment: Amir Tanay, Eyal Leibovitz, Angela Frayman, Rueven Zimlichman, Dov Gavish.
4. Sun–Induced Life–Threatening Lupus Nephritis: Enno Schmidt, Hans–Peter Tony, Eva–Bettina Bröcker, Christian Kneitz.
5. Blood Concentrations of Hydroxychloroquine and its Desethyl Derivative Correlate Negatively with the Percentage of CD45RO+ Cells Among CD4+ Lymphocytes in Hydroxychloroquine Treated Lupus Patients: Laurent Sailler, Bénédicte Puissant, Pascal Méliani, Jean Olivier Castex, Sylvie Saivin, D. Adoue, B. Fournie, Philippe Arlet, Jean–Louis Montastruc, Maryse Laoetyre–Mestre, Jaques Pourrat, Antoine Blancher.
6. Advances in Lupus and Sjögren’s Syndrome. A Tribute to Josep Font: Manuel Ramos–Casals, Munther A. Khamashta.
7. Regulatory T Cells and Systemic Lupus Erythematosus: Véronique Parietti, Hélène Chifflot, Sylviane Muller, Fanny Monneaux.
8. Occurrence of Malignancies in Hungarian Patients with Systemic Lupus Erythematosus. Results from a Single Centre: Tünde Tarr, Balázs Gyorfy, Éva Szekanecz, Harjit Pal Bhattoa, Margit Zeher, Gyula Szegedi, Emese Kiss.
9. Reduced Paraoxonase1 Activity is a Risk for Atherosclerosis in Patients with Systemic Lupus Erythematosus: Emese Kiss, Ikdikó Seres, Tünde Tarr, Zsolt Kocsis, Gyula Szegedi, György Paragh.
10. A Potential Trigger of Nephritogenic Anti–DNA Antibodies in Lupus Nephritis: Y. Hirabayashi, Y. Oka, M. Tada, R. Takahashi, T. Ishii.
11. Annexin A5 as a Novel Player in Prevention of Atherithrombosis in SLE and in the General Population: Anna Cederholm, Johan Frostegärd.
12. A Central Role of Nucleosomes in Lupus Nephritis: Kristen A. Fenton, Ole Petter Rekvig.
13. Systemic Lupus Erythematosus: The Face of Asia: Pao–Hsii Feng.
14. Intima–Media Thickness (IMT): A Marker of Accelerated Atherosclerosis in Women with SLE: Barbara Maria Colombo, Giuseppe Murdaca, Matteo Caiti, Guido Rodriguez, Lidia Grassia, Edorado Rossi, Francesco Indiveri, Francesco Puppo.
15. DNA Methylation and Systemic Lupus Erythematosus: Eva Balada, Josep Ordi–Ros, Miguel Vilardell–Tarrés.
16. Antibodies Towards High Density Lipoprotein Components Inhibit Paraoxonase Activity in Patient with Systemic Lupus Erythematosus: J. R. Batuca, P.R.J. Ames, D.A. Issenberg, Alves J. Delgado.
17. Induction of Endothelial Cell Apoptosis by IgG Antibodies from SLE Patients with Nephropathy: A Potential Role for Anti–endothelial–cell–antibodies (AECA): P. van Paassen, A, Duijvestijn, L. Debrus–Palmans, J. Damoiseaux, M. Vroomen, J.W. Cohen Tervaert.
18. Prolactine Effect on Lymphocytes Activation From Systemic Lupus Erythematosus Patients: Chavez–Rueda Karina, Legorreta–Haquet Ma. Victoria, Cervera–Castillo Hernando, Sánchez Lourdes, Jara Luis Javier, Zenteno Edgar, Chavez–Sanchez Luis, Blanco–Favela Francisco.
19. Drug–Induced Lupus: Andrea T. Borchers, Carl L. Keen, M. Eric Gershwin.
and Complement Receptors20. Altered Expression of Fc on B Cells in Systemic Lupus Erythematosus: Péter Gergely Jr., Andrea Isaák, Zsuzsanna Szekeres, József Prechl, Anna Erdei, Zsolt B. Nagy, János Gergely, Gyula Poór.
21. Pediatric Systemic Lupus Erythematosus with C1q Deficiency: Maryam Kallel Sellami, Lilia Baili Klila, Yousr Zerzeri, Lillia Laadhar, Jaques Blouin, Mohamed Slim Abdelmoula, Mondher Aitoun, Véronique Fremeaux–Bacchi, Marie France Ben Dridi, Sondes Makni.
22. Hereditary Complement Deficiency and Lupus: Report f 4 Tunisian Cases: Maryam Kallel Sellami, Lilia Baili Klila, Yousr Zerzeri, Lillia Laadhar, Jaques Blouin, Rim Abdelmalek, Véronique Fremeaux–Bacchi, Mondher Zitouni, Sondes Makni.
23. Highly Specific Novel Method for Isolation and Purification of Lupus Anti–DNA Antibody Via Oligo– (DT) Magnetic Bead s: Mirjana Pavlovic, Ram Chen, Anna M. Kats, Michelle F. Cavallo, Seth Saccocio, Patricia Keating, James X. Hartmann.
24. Proactin Levels are Associated with Lupus Activity, Lupus Antcoagulant and Poor Outcome in Pregnancy: Luis J. Jara, Heidi Pacheco–Reyes, Gabriela Medina, Ulises Angeles, Polita Cruz–Cruz, Miguel A. Saavedra.
25. Autoantibodies Against Protective Molecules –C1q, C–reactive Protein (CRP), Serum Amyloid P (SAP), Mannose–binding Lectin (MBL), and Apolipoprotein A1 (Apo A1). Prevalence in Systemic Lupus Erythematosus: Yehuda Shoenfeld, Martine–Szyper–Kravitz, Tortsen Witte, Andrea Doria, Akito Tsutsumi, Abe Tatsuya, Jean–Michel Dayer, Pascale Roux–Lombard, Lionel Fontao, Cees G.M. Kallenberg, Marc Bijl, Torsten Mattias, Abigail Fraser, Gisele Zandman–Goddard, Miri Blank, Boris Gilburd, Pier Luigi Meroni.
Part II: Scleroderma:.
26. Unstabilized DNA Breaks in Lymphocytes of Patients With Different Subsets of Systemic Sclerosis: Franco Majone, Franco Cozzi, Marta Tonello, Silvia Olivieri, Anna Montaldi, Maria Favari, Serena Visentin, Roberto Luisetto, Amelia Ruffatti.
27. Scleroderna Renal Crisis, Still a Life Threatening Complication:Luis Teixeira, Alfred Mahr, Alice Berezné, Laure–Hélène Noël, Loïc Guillevin, Luc Mouthon.
28. Early Atherosclerosis and Autoantibodies to Heat–Shock Proteins and Oxidized LDL in Systemic Sclerosis: Yaniv Sherar, Marco Matucci Cerinic, Francesca Bartoli, Jelena Blagojevic, Maria Letizia Conforti, Boris Gliburd, Michael Ehrenfeld, Yehuda Shoenfeld.
29. Systemic Sclerosis Associated Myopathy: Brigitte Ranque, Francois–Jérome Authier, Alice Berenze, Loïc Guillevin, Luc Mouthon.
30. Flow Mediated Vasodilation and Carotid Intima–Media Thickness in Systemic Sclerosis: Francesca Bartoli, Jelena Blagojevic, Marzia Bacci, Ginevra Fiori, Alessio Tempestini, MariaLetizia Conforti, Seren