Biogerontology: Mechanisms and Interventions, Volume 1100

Biological aging and interventionary strategies are investigated with the eventual goal of extending healthy human lifespan and minimizing the incidence of diseases associated with aging.
Biogerontologists, evolutionary biologists, biodemographers, scientists in related basic research, clinicians, and dieticians came together in Istanbul, Turkey, to share their research and discuss the latest developments in this rapidly advancing field.
This volume presents chapters representative of the highlights of the meeting, including contributions in the following areas: (1) biological and nonbiological factors affecting lifespan and the quality of life; (2) ethical and social issues related to lifespan and health–span extension; (3) novel areas of understanding aging –– physiological, cellular, and molecular aspects; (4) new technologies to understand and modulate aging; (5) the latest successful approaches in the prevention and treatment of age–related diseases; and (6) aging intervention, prevention, and modulation by genes, natural and synthetic molecules, and lifestyle modifications.
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Spis treści:
Preface: Biogerontology: Mechanisms and Interventions: Suresh I. S. Rattan and Serif Akman.
Part I: Aging, Longevity and Evolution:.
1. Biological Aging is No Longer an Unsolved Problem: Leonard Hayflick.
2. Modalities of Gene Actio n Predicted by the Classical Evolutionary Biological Theory of Aging: George M. Martin.
3. Genetics of Healthy Aging in Europe: The EU–Integrated Project GEHA (Genetics of Healthy Aging): Claudio Franceschi, Vladyslav Bezrukov, Helene Blanche, Lars Bolund, Kaare Christensen, Giovanna De Benedictis, Luca Deiana, Efsthatios Gonos, Antti Hervonen, Huanning Yang, Bernard Jeune, Tom B. L. Kirkwood, Peter Kristensen, Alberta Leon, Pier Giuseppe Pelicci, Leena Peltonen, Michel Poulain, Irene Maeve Rea, Jose Remacle, Jean Marie Robine, Stefan Schreiber, Ewa Sikora, Pieternella Eline Slagboom, Liana Spazzafumo, Maria Antonietta Stazi, Olivier Toussaint, and James W. Vaupel.
4. Postponement of Postmenopausal Mortality Acceleration in Low–Mortality Populations: Eugene M. G. Milne.
5. Cross–Talk between Aging and Cancer: The Epigenetic Language: Mario F. Fraga, Ruben Agrelo, and Manel Esteller.
6. Molecular Chaperones and the Epigenetics of Longevity and Cancer Resistance: Jens Kroll.
Part II: Immunity, Aging and Diseases:.
7. Regulation of Human Life Histories: The Role of the Inflammatory Host Response: David Van Bodegom, Linda May, Hans J. Meij, and Rudi G. J. Westendorp.
8. Do Membrane Rafts Contribute to Human Immunosenescence?: Andru Tomoiu, Anis Larbi, Carl Fortin, Gilles Dupuis, and Tamas Fulop, Jr.
9. Zinc and Inflammatory/Immune Response in Aging: Sonya Vasto, Eugenio Mocchegiani, Marco Malavolta, Irene Cuppari, Florinda Listi, Domenico Nuzzo, Vito Ditta, Giuseppina Candore, and Calogero Caruso.
10. Genetics of Inflammation in Age–Related Atherosclerosis: Its Relevance to Pharmacogenomics: Maria Paola Grimaldi, Sonya Vasto, Carmela Rita Balistreri, Daniele Di Carlo, Marco Caruso, Egle Incalcaterra, Domenico Lio, Calogero Caruso, and Giuseppina Candore.
11. PECAM–1/CD31 in Infarction and Longevity: Florinda Listi, Calogero Caruso, Carmela Rita Balistreri, Maria Paola Grimaldi, Marco Caruso, Gregorio Ca imi, Enrico Hoffmann, Domenico Lio, and Giuseppina Candore.
12. Plasma Levels of Apolipoprotein E and Risk of Stroke in Old Age: Peter Van Vliet, Simon P. Mooijaart, Anton J. M. De Craen, Patrick C. N. Rensen, Diana Van Heemst, and Rudi G. J. Westendorp.
13. Plasma Levels of Apolipoprotein E and Cognitive Function in Old Age: Simon P. Mooijaart, Peter Van Vliet, Diana Van Heemst, Patrick C. N. Rensen, Jimmy F. P. Berbee, Jelle Jolles, Anton J. M. De Craen, and Rudi G. J. Westendorp.
14. CCR5 Receptor: Biologic and Genetic Implications in Age–Related Diseases: Carmela Rita Balistreri, Calogero Caruso, Maria Paola Grimaldi, Florinda Listi, Sonya Vasto, Valentina Orlando, Anna Maria Campagna, Domenico Lio, and Giuseppina Candore.
15. Lumbar Spinal Stenosis in Elderly Patients: Hulagu Kaptan, Omur Kasimcan, Kutay Cakiroglu, Mustafa Necmi Ilhan, and Celal Kilic.
16. Comparison of Lipoprotein(a) Levels between Elderly and Middle–Aged Men with Coronary Artery Disease: Hulya Cicek, Sibel Bayil, Yasemin Zer, Ahmet Celik, and Iclal Geyikli.
17. Chitotriosidase Levels in Healthy Elderly Subjects: Ismail Kurt, Dilek Abasli, Murat Cihan, Muhittin A. Serdar, Abdullah Olgun, Ercan Saruhan, and M. Kemal Erbil.
18. Genetic Variation in the Interleukin–10 Gene Promoter and Risk of Coronary and Cerebrovascular Events: The PROSPER Study: S. Trompet, D. Pons, A. J. M. De Craen, P. Slagboom, J. Shepherd, G. J. Blauw, M. B. Murphy, S. M. Cobbe, E.L.E.M. Bollen, B. M. Buckley, I. Ford, M. Hyland, A. Gaw, P. W. Macfarlane, C. J. Packard, J. Norrie, I. J. Perry, D. J. Stott, B. J. Sweeney, C. Twomey, R. G. J. Westendorp, J. W. Jukema, and on behalf of the PROSPER Group.
19. Antioxidant Enzymes and Diabetic Retinopathy: Zuhal Yildirim, N. Irem Ucgun, Nedret Kilic, E. Gursel, and Aylin Sepici–Dincel.
20. Pseudoexfoliation Syndrome and Trace Elements: Zuhal Yildirim, N. Irem Ucgun, Nedret Kilic, E. Gursel, and Aylin Sepici–Dincel.
21. The Importance of Serum Lipids in Exudative Diabetic Macular Edema in Type 2 Diabetic Patients: Nil Irem Ucgun, Zuhal Yildirim, Nedret Kilic, and Emin Gursel.
22. Age–Related Paraoxonase Activity Changes in Turkish Population: Ercan Saruhan, Abdullah Olgun, Kamile Ozturk, Serif Akman, and M. Kemal Erbil.
23. Evaluation of Measurement Uncertainty of Glucose in Clinical Chemistry: B. Bercik Inal, M. Koldas, H. Inal, C. Cockun, A. Gumus, and Y. Doventas.
Part III: Molecular and Cellular Aging:.
24. Mitochondrial DNA Mutations and Aging: Kim J. Krishnan, Laura C. Greaves, Amy K. Reeve, and Douglass M. Turnbull.
25. Mitochondrial DNA–Deficient Models and Aging: Abdullah Olgun and Serif Akman.
26. Mitochondrial DNA Alterations in Aging: Kamile Ozturk, Abdullah Olgun, Ercan Saruhan, Aydan Ergen, Serif Akman, and M. Kemal Erbil.
27. Alterations to Nuclear Architecture and Genome Behavior in Senescent Cells: Ishita S. Mehta, Martin Figgitt, Craig S. Clements, Ian R. Kill, and Joanna M. Bridger.
28. PGC–1α–Induced Mitochondrial Alterations in 3T3 Fibroblast Cells: Huiyun Liang, Yidong Bai, Youfen Li, Arlan Richardson, and Walter F. Ward.
29. Proteasome and Photoaging: The Effects of UV Irradiation: Anne–Laure Bulteau, Marielle Moreau, Carine Nizard, and Bertrand Friguet.
30. Proteome Alterations in Rat Mitochondria Caused by Aging: Norbert A. Dencher, Monika Frenzel, Nicole H. Reifschneider, Michiru Sugawa, and Frank Krause.
31. The Role of the MORF/MRG Family of Genes in Cell Growth, Differentiation, DNA Repair, and Thereby Aging: Andreana N. Pena and Olivia M. Pereira–Smith.
32. Involvement of Mortalin in Cellular Senescence from the Perspective of its Mitochondrial Import, Chaperone, and Oxidative Stress Management Functions: Tomoko Yaguchi, Satoshi Aida, Sunil C. Kaul, and Renu Wadhwa.
33. CARF Binds to Three Members (ARF, p53, and HDM2) of the p53 Tumor–Suppressor Pathway: Hasa