Autoimmunity, Part A: Basic Principles and New Diagnostic Tools, Volume 1109

The incidence of autoimmune diseases is increasing worldwide, and the search for better management of these diseases and even for a cure is being pursued by scientists from many disciplines. Tools from the areas of genetics, neuroscience, cell biology, virology, and infectious disease are being applied to the problem and are yielding useful results.
This volume contains the first section of the proceedings of a large, comprehensive meeting held in Sorrento, Italy. Because the meeting focused on such an important area of human health, four volumes have been dedicated to it: Part A presents new principles in autoimmunity, including the roles of key players such as designed ankyrin repeat proteins, SLAM–associated protein, interleukin–12, human proteinase 3, the complement system, IgG, disturbances in cytokine synthesis, and IFN–γ blockers. The second section of the volume takes a look at new diagnostic tools, including screening of endothelial expression libraries, electrical skin impedance, and IgA anti–tissue transglutaminase antibody assays.
Autoimmunity, Part B continues the presentation of basic research and its applications with a focus on genetics. Parts C and D present the clinical research in various manifestations of autoimmune disease and its treatments.
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Spis treści:
Foreword (M. Eric Gershwin and Yehuda Shoe nfeld).
Part I: New Principles of Autoimmunity.
1. The Nature and Nurture of Common Autoimmunity (John Castiblanco and Juan–Manuel Anaya).
2. Designed Ankyrin Repeat Proteins as Anti–Idiotypic Binding Molecules (Monique Vogel, Elsbeth Keller–Gautschi, Michael J. Baumann, Patrick Amstutz, Christine Ruf, Franz Kricek, Beda M. Stadler).
3. SLAM–Associated Protein (SAP) Solves a Mystery of Autoimmunity: (Shigemasa Sawada, Masami Takei, Tetsuyosi Ishiwata, Hidetaka Shiraiwa, Hirotake Inomata, Takamasa Nozaki).
4. Standardization of Autoimmune Diagnostics in Germany – Activities of the German Group in the European Autoimmune Standardisation Initiative (Ulrich Sack, Karsten Conrad, Elena Csernok, Ingrid Frank, Michael Haass, Torsten Krieger, Michael Seyfarth, Udo Schlosser, Reinhold E. Schmidt, Torsten Witte).
5. Autoimmunity and Time Entanglement (Juan I. Poo, Pablo I. Martin, Enrique Rewald).
6. The Pro– and Anti–Inflammatory Potential of Interleukin–12 (Hyun–Dong Chang, Andreas Radbruch).
7. NKG2D and Natural Cytotoxicity Receptors Are Involved in Natural Killer Cell Interaction with Self–Antigen Presenting Cells and Stromal Cells (Poggi Alessandro, Prevosto Claudia, Zancolli Marta, Paolo Canevali, Alessandra Musso, Zocchi Maria Raffaella).
8. The Role of Toll–Like Receptors in HMGB1 Release from Macrophages (David S. Pisetsky, Weiwen Jiang).
9. Immune Complex Pathophysiology (Urs E. Nydegger).
10. Human Proteinase 3 (PR3) and Its Binding Molecules: Implications for Inflammatory and PR3–Related Autoimmune Responses (Antje Müller, Jan Voswinkel, Stefan Gottschlich, Elena Csernok).
11. Loss of Self–Control in the Complement System and Innate Autoreactivity (Seppo Meri).
12. Immunodeficiency and Autoimmune Phenomena in Female Hyper IgM Syndrome (HIGM) (Melegari Alessandra, Mascia Maria Teresa, Sandri Gilda, Carbonieri Anna).
13. Autoimmune Di seases of Domestic Animals (Laurel J. Gershwin).
14. Prediction and Prevention of Autoimmune Disease: A Personal Perspective (Noel R. Rose).
15. Alterations of Th1/Th2 Reactivity by Heavy Metals: Possible Consequences Include Induction of Autoimmune Diseases (Nasr Y.A. Hemdan, Frank Emmrich, Sonya Faber, Ulrich Sack).
16. EASI – The European Autoimmunity Standardisation Initiative: A New Initiative That Can Contribute to Agreed Diagnostic Models of Diagnosing Autoimmune Disorders Throughout Europe (Yehuda Shoenfeld, Ricard Cervera, Michael Haass, Cees Kallenberg, Munther Khamashta, Pier Luigi Meroni, Jean–Charles Piette, Reinhold Schmidt, Allan Wiik).
17. Effector Memory CD8+ T Cells Are Resistant to Apoptosis (Sudhir Gupta, Sastry Gollapudi).
18. Two–Step Mechanism of Virus–Induced Autoimmune Hemolytic Anemia (Jean–Paul Coutelier, Laurent Detalle, Andrei Musaji, Mory Meite, Shozo Izui).
19. Autoimmune Reactions After Electro–Oxidation of IgG from Healthy Persons. Relevance of Electric Current and Antioxidants (Borut Bozic, Sasa Cucnik, Tanja Kveder, Blaz Rozman).
20. Autoimmune Diseases Are Connected With Disturbances In Cytokine Synthesis and Therapy With IFN–g Blockers Is Their Main Pathogenetic Treatment (Boris Skurkovich, Simon Skurkovich).
Part II: New Tools in Diagnosis.
21. Screening of Endothelial Expression Libraries for the Identification of Novel Autoantigens Involved in Distinct Autoimmune Diseases Characterized by Endothelial Dysfunction (Paola Margutti, Federica Delunardo, Tania Colasanti, Ettore Piro, Elisabetta Profumo, Rachele Riganò, Alessandra Siracusano, Brigitta Buttari, Fabrizio Conti, Cristiano Alessandri, Antonella Capozzi, Maurizio Sorice, Elena Ortona).
22. Diagnosing Diseases by Mesurement of Electrical Skin Impedance: A Novel Technique (Rony Weitzen, Nava Epstein, Yehuda Shoenfeld, Eyal Zimlichman).
23. Antigen Preparation for Immunological Studies in Systemic Autoimmune Diseases (Sandra Zampieri, Anna Ghirardello, Katia Rossini, Luca Iaccarino, Nicola Bassi, Fabiola Atzeni, PierCarlo Sarzi–Puttini, Andrea Doria).
24. Comparison of Two Elisa Assays for Anti–SP100 Determination (José Manuel Lucena, Marcos Montes Cano, José Luis Caro, Nieves Respaldiza, Antonia Alvarez, Julio Sánchez–Román, Antonio Núñez–Roldán, Ingeborg Wichmann).
25. Diagnostic Accuracy of IgA Anti–Tissue Transglutaminase Antibody Assays in Celiac Disease Patients with Selective IgA Deficiency (D. Villalta, M.G. Alessio, M. Tampoia, E. Tonutti, I. Brusca, M. Bagnasco, G. Pesce, N. Bizzaro).
26. Anti–Topoisomerase 1 Antibodies in Systemic Sclerosis: How to Improve the Detection (Mathieu C. Tamby, Guillaume Bussone, Luc Mouthon).
27. The Effect of Open Heart Surgery on Tuberculin Skin Test Reactivity (Michal Stein, Batia Sela–Razon, Ilan Linder, Eli Somekh).
28. The Reliability of Control Skin Tests with Common Antigens in Children Undergoing Tuberculin Skin Test (Michal Stein, Batia Sela–Razon, Yeshayaou Kleter, Eli Somekh).
29. Ena Screen Chemiluminescence Immunoassay: A Random Access Method in Autoimmunology (S. Signorini, I. Kutschera, F. Capuano, L. Lattuada).
30. Evaluation of the BioPlex 2200™ ANA Screen for the Detection of Anti–Nuclear Antibodies and Comparison with Conventional Methods (Sophie Desplat–Jego, Nathalie Bardin, Bruno Larida, Marielle Sanmarco).
31. A New Line Immunoassay for the Multiparametric Detection of Anti–Ganglioside Autoantibodies in Patients with Autoimmune Peripheral Neuropathies (Karsten Conrad, Hauke Schneider, Tjalf Ziemssen, Thomas Talaska, Dirk Reinhold, Rene–Louis Humbel, Dirk Roggenbuck).
32. Lipocalin–2, Tweak and Other Cytokines as Urinary Biomarkers for Lupus Nephritis (Noa Schwartz, Jennifer S. Michaelson, Chaim Putterman).
33. The Prevalence of Anti–