Signal Transduction Pathways, Part B: Stress Signaling and Transcriptional Control, Volume 1091

This is the second volume to emerge from the cell signaling meeting in Luxembourg (see Part A) to discuss therapeutic applications in the field of signal transduction, transcription, and translation. These meetings and the volumes comprising their proceedings have brought forward new insights in this rapidly moving field. These volumes focus on the therapeutic potential for targeting cell signaling mechanisms with particular attention to cancer therapies and inflammatory signaling pathways as well as immunomodulation.
Part B focuses on basic research, and the chapters are divided into the following sections: oxidative stress, transcriptional control, HDAC, and novel technological and therapeutic approaches.
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Spis treści:
Part I: Oxidative Stress:.
1. Oxidative Upregulation of Bcl–2 in Healthy Lymphocytes: Silvia Cristofanon, Silvia Nuccitelli, Maria D’alessio, Flavia Radogna, Milena De Nicola, Antonio Bergamaschi, Claudia Cerella, Andrea Magrini, Marc Diederich, and Lina Ghibelli.
2. Intracellular Pro–oxidant Activity of Melatonin Deprives U937 Cells of Reduced Glutathione without Affecting Glutathione Peroxidase Activity: Maria Cristina Albertini, Flavia Radogna, Augusto Accorsi, Francesco Uguccioni, Laura Paternoster, Claudia Cerella, Milena De Nicola, Maria D’alessio, Antonio Bergamaschi, Andrea Magrini, and Lina Ghibelli.
3. Mitochondrial "Movement" and Lens Optics following Oxidative St ress from UV–B Irradiation: Cultured Bovine Lenses and Human Retinal Pigment Epithelial Cells (ARPE–19) as Examples: Vladimir Bantseev and Hyun–Yi Youn.
4. 2–Methoxyestradiol Inhibits Superoxide Anion Generation while It Enhances Superoxide Dismutase Activity in Swine Granulosa Cells: Giuseppina Basini, Sujen Eleonora Santini, and Francesca Grasselli.
5. Role of Reactive Oxygen Species in Kv Channel Inhibition and Vasoconstriction Induced by TP Receptor Activation in Rat Pulmonary Arteries: Angel Cogolludo, Giovanna Frazziano, Laura Cobeno, Laura Moreno, Federica Lodi, Eduardo Villamor, Juan Tamargo, and Francisco Perez–Vizcaino.
6. DNA Strand Breaks by Metal–Induced Oxygen Radicals in Purified Salmonella typhimurium DNA: Ezzatollah Keyhani, Fatemeh Abdi–Oskouei, Farnoosh Attar, and Jacqueline Keyhani.
7. Antioxidant Enzymes during Hypoxia–Anoxia Signaling Events in Crocus sativus L. Corm: Ezzatollah Keyhani, Lila Ghamsari, Jacqueline Keyhani, and Mahnaz Hadizadeh.
8. Ataxia–Telangiectasia–Mutated–Dependent Activation of Ku in Human Fibroblasts Exposed to Hydrogen Peroxide: Jong Hwa Lee, Ji Hoon Yu, Kyung Hwan Kim, and Hyeyoung Kim.
9. Regulation of 2–Deoxy–D–Glucose Transport, Lactate Metabolism, and MMP–2 Secretion by the Hypoxia Mimetic Cobalt Chloride in Articular Chondrocytes: Ali Mobasheri, Nicola Platt, Colin Thorpe, and Mehdi Shakibaei.
10. Oxidative Stress Response in Telomerase–Immortalized Fibroblasts from a Centenarian: Chiara Mondello, Maria Grazia Bottone, Sakon Noriki, Cristiana Soldani, Carlo Pellicciari, and Anna Ivana Scovassi.
11. Differential Modulation of AMPK Signaling Pathways by Low or High Levels of Exogenous Reactive Oxygen Species in Colon Cancer Cells: In–Ja Park, Jin–Taek Hwang, Young Min Kim, Joohun Ha, and Ock Jin Park.
12. Alterations in Salivary Antioxidants, Nitric Oxide, and Transforming Growth Fac tor–B1 in Relation to Disease Activity in Crohn’s Disease Patients: Ali Rezaie, Fakhteh Ghorbani, Azadeh Eshghtork, Mohammad J. Zamani, Gholamreza Dehghan, Bardia Taghavi, Shekoufeh Nikfar, Azadeh Mohammadirad, Nasser E. Daryani, and Mohammad Abdollahi.
13. Control of Bioamine Metabolism by 5–HT2B and B1D Autoreceptors through Reactive Oxygen Species and Tumor Necrosis Factor–a Signaling in Neuronal Cells: Benoit Schneider, Mathea Pietri, Sophie Mouillet–Richard, Myriam Ermonval, Vincent Mutel, Jean–Marie Launay, and Odile Kellermann.
14. Determination of Oxidative Stress Status and Concentration of TGF–B1 in the Blood and Saliva of Osteoporotic Subjects: Gholamreza Yousefzadeh, Bagher Larijani, Azadeh Mohammadirad, Ramin Heshmat, Gholamreza Dehghan, Roja Rahimi, and Mohammad Abdollahi.
Part II: Transcriptional Control:.
15. Targeting Signal–Transducer–and–Activator–of–Transcription–3 for Prevention and Therapy of Cancer: Modern Target but Ancient Solution: Bharat B. Aggarwal, Gautam Sethi, Kwang Seok Ahn, Santosh K. Sandur, Manoj K. Pandey, Ajaikumar B. Kunnumakkara, Bokyung Sung, and Haruyo Ichikawa.
16. Gene Expression Modulation in A549 Human Lung Cells in Response to Combustion–Generated Nano–Sized Particles: Andrea Arenz, Christine E. Hellweg, Nevena Stojicic, Christa Baumstark–Khan, and Horst–Henning Grotheer.
17. Multiple Levels of Control of the Expression of the Human A—H–J–J Locus Encoding Aspartyl–b–hydroxylase, Junctin, and Junctate: Giordana Feriotto, Alessia Finotti, Giulia Breveglieri, Susan Treves, Francesco Zorzato, and Roberto Gambari.
18. Activation of Nuclear Factor kB by Different Agents: Influence of Culture Conditions in a Cell–Based Assay: Christine E. Hellweg, Andrea Arenz, Susanne Bogner, Claudia Schmitz, and Christa Baumstark–Khan.
19. Atrial Appendage Transcription al Profile in Patients with Atrial Fibrillation with Structural Heart Diseases: Maria S. Kharlap, Angelica V. Timofeeva, Ludmila E. Goryunova, George L. Khaspekov, Sergey L. Dzemeshkevich, Vladimir V. Ruskin, Renat S. Akchurin, Sergey P. Golitsyn, and Robert Sh. Beabealashvilli.
20. DNA Hypomethylation of CAGE Promotors in Squamous Cell Carcinoma of Uterine Cervix: Taek Sang Lee, Jae Weon Kim, Gyeong Hoon Kang, Noh Hyun Park, Yong Sang Song, Soon Beom Kang, and Hyo Pyo Lee.
21. The MECP2 Gene Mutation Screening in Rett Syndrome Patients from Croatia: Tanja Matijevi, Jelena Knezevic, Ingeborg Barisic, Biserka Resic, Vida Culic, and Jasminka Pavelic.
22. Prostaglandins Regulate Transcription by Means of Prostaglandin Response Elements Located in the Promoters of Mammalian Na,K–ATPase B1 Subunit Genes: Keikantse Matlhagela and Mary Taub.
23. Different Modulation of ER–Mediated Transactivation by Xenobiotic Nuclear Receptors Depending on the Estrogen Response Elements and Estrogen Target Cell Types: Gyesik Min.
24. Effects of TK Promotor and Hepatocyte Nuclear Factor–4 in CAR–Mediated Transcriptional Activity of Phenobarbital Responsive Unit of CYP2B Gene in Monkey Kidney Epithelial–Derived Cell Line COS–7: Gyesik Min.
25. Expression of the E2F Family of Transcription Factors and Its Clinical Relevance in Ovarian Cancer: Daniel Reimer, Susann Sadr, Annemarie Wiedemair, Georg Goebel, Nicole Concin, Gerda Hofstetter, Christian Marth, and Alain G. Zeimet.
26. Isolation and Characterization of the Rat SND p102 Gene Promoter: Putative Role for Nuclear Factor–Y in Regulation of Transcription: Lorena Rodrıguez, Nerea Bartolome, Begona Ochoa, and Marıa J. Martınez.
27. The cAMP–Responsive Unit of the Human Insulin–Like Growth Factor–Binding Protein–1 Coinstitutes a Functional Insulin–Response Element: Ghislaine Schweizer–Groyer, Guillaume Fallot, Francoise Cadep