Immunology of Diabetes IV: Progress in Our Understanding, Volume 1079

The incidence of diabetes in increasing all over the world and has become a major public health problem. This volume brings together reports from scientists working in the fields of immunology genetics that that report on basic research as well as current approaches to treatment in the clinic.
Reports from workshops on autoantibodies and T cells are included, as are chapters covering target autoantigens, innate immunity in type 1 diabetes, fluminant type 1 diabetes, and the role of viral infections in type 1 diabetes. The genetics of LADA and SPIDDM are presented as well as a comparison of their immunoepidemiology and immunopathological features. A section on genetics and the characteristics of susceptible genes concludes the basic research.
The clinical topices covered include islet regeneration and the use of stem cells in mediating tolerance for type 1 diabetes prevention. Reports on the progress on islet transplantation conclude the volume.
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Spis treści:
Part I: Special Papers:.
1. The Type 1 Diabetes Genetics Consortium: Stephen S. Rich, Patrick Concannon, Henry Erlich, Cecile Julier, Grant Morahan, Jorn Nerup, Flemming Pociot, John A. Todd.
2. A Mini Meta–Analysis of Studies on CD4+CD25+ T Cells in Human Type 1 Diabetes; Report of the Immunology of Diabetes Society T Cell Workshop: Timothy I.M. Tree, Bart O Roep and Mark Peakman.
3. HLA Class I Epitope Discovery in Type I Diabetes: Independent and Reproducible Identification of Proinsulin Epitopes of CD8 T–Cells. Gabrielle G. M. Pinkse, Christian Boitard, Timothy I.M Tree, Mark Peakman and Bart O. Roep.
Part II: Diabetes in Asia:.
4. Genetics of Fluminant Type 1 Diabetes. Eiji Kawasaki, Katsumi Eguchi.
5. Why is Type 1 Diabetes Uncommon in Asia?: Yongsoo Park.
6. Association of SUMO4, as a Candidate Gene for IDDM5, with Susceptibility to Type 1 Diabetes in Asian Populations: Shinsuke Noso, Hiroshi Ikegami, Tomomi Fujisawa, Yumiko Kawabata, Katsuaki Asano, Yoshihisa Hiromine, Miyuki Moritani, Shigetaka Sugihara, Inkyu Lee, Eiji Kawasaki, Takuya Awata, Toshio Ogihara.
7. The Gene for Human IL–21 and Genetic Susceptibility to Type 1 Diabetes in Japanese: Katsuaki Asano, Hiroshi Ikegami, Tomomi Fujisawa, Yumiko Kawabata, Shinsuke Noso, Yoshihisa Hiromine, Toshio Ogihara.
8. Genetics of Type 1 Diabetes: Similarities and Differences Between Asian and Caucasian Populations: Hiroshi Ikegami, Tomomi Fujisawa, Yumiko Kawabata, Shinsuke Noso, Toshio Ogihara.
Part III: Latent Autoimmune Diabetes in Adults (LADA):.
9. Immunopathological and Genetic Features in Slowly Progressive Insulin–Dependant Diabetes Mellitus (SPIDDM) and Latent Autoimmune Diabetes in Adult (LADA): Tetsuro Kobayashi, Shoichiro Tanaka, Norikazu Harii, Kaoru Aida, Hiroki Shimura, Masayuki Ohmori, Masahiro Kanesige, Akira Shimada, Taro Maruyama.
10. Genes Influencing Innate and Acquired Immunity in Type 1 Diabetes and Latent Autoimmune Diabetes in Adults: Carani B Sanjeevi.
11. Progression of Autoimmune Diabetes: Slowly Progressive Insulin Dependent Diabetes Mellitus (SPIDDM) or Latent Autoimmune Diabetes of Adult (LADA): Huriya Beyan, Thomas Ola, R. David G. Leslie.
12. Immunomodulation for the Prevention of SPIDDM and LADA: P.Pozzilli, C. Guglielmi.
Part IV: Animal Models:.
13. Heightened Interferona/b Response Causes Myeloid Cell Dysfunction and Promotes T1D Pathogenesis in NOD Mice: Ruihua Peng, Paek E., Xia C.Q., Tennyson N., and M.J. Clare–Salzler.
14. Immunolocalization of Monocyte Chemoattractant Protein–1 (MCP–1) in Islets of NOD Mice During Cyclophosphamide Administration: Shiva Reddy, Yan Bai, Elizabeth Robinson, Jacqueline Ross.
15. Young NOD Mice Show Increased Diabetes Sensitivity to Low Doses of Streptozotocin: Shiva Reddy, Mike Chang, Elizabeth Robinson.
16. Contribution of Class III MHC to Susceptibility to Type 1 Diabetes in the NOD Mouse: Kaori Yamaji, Hiroshi Ikegami, Tomomi Fujisawa, Shinsuke Noso, Koji Nojima, Naru Babaya, Michiko Itoi–Babaya, Mistao Kobayashi, Yoshihisa Hiromine, Susumu Makino, Toshio Ogihara.
17. Mhc– Linked Susceptibility to Type 1 Diabetes in the NOD Mouse: Further Localization of IDD16 by Subcongenic Analysis: Tomomi Fujisawa, Hiroshi Ikegami, Kaori Yamaji, Koji Nojima, Naru Babaya, Mchiko Itoi–Babaya, Yoshimasa Hiromine, Misato Kobayashi, Susumu Makino, Toshio Ogihara.
18. Long–Term Prevention of Diabetes and Marked Suppression of Insulin Autoantibodies and Insulitis in Mice Lacking Native Insulin B9–23 Sequence: M. Nakayama, N. Babaya, D. Miao, R. Gianani, E. Liu, J. F. Elliot, G. S. Eisenbarth.
19. Eicosanoid Imbalance in the NOD Mouse is Related to a Dysregulation in Soluble Epoxide Hydrolase and 15–PGDH Expression: Michelle Rodriguez and Macheal Clare Salzler.
20. Pancreatic Autoimmunity Induction with Insulin B:9–23 Peptide and Viral Mimics in the NZB Mouse: Devasenan Devendra, Dongmei Miao, Maki Nakayama, George S. Eisenbarth and Edwin Liu.
21. Viruses Cause Type 1 Diabetes in Animals : Ji–Won Yoon and Hee–Sook Jun.
22. Characterization of PAF–AH IB1 in NOD Mice: PAF–AH IB1 May Not be a Candidate of Diabetes Susceptibility IDD4.1 Locus: Qing–Shen Mi, Li Zhou, Marsha Grattan, Zai–Zhao Wang, M. Sivilotti, Jing–Xiang She and Terry L Delovitch.
23. Peptide–Pulsed Immature Dendritic Cells Reduce Response to Β Cell Target Antigens and Protects NOD Recipients from Type 1 Diabetes: Jeannette Lo, Rui Hua Peng, Tolga Barker and Michael J. Clare–Salzler.
24. New Members of the Interleukin–12 (IL–12) Family of Cytokines, IL–23 and IL–.
Part V: T–Cells:.
25. Glutamic Acid Decarboxylase–Specific CD4+ Regulatory T Cells: Chih–Pin Liu.
26. Metabolism Genes are Amongst the Differentially Expressed Ones Observed in Lymphomononuclear Cells of Recently Diagnosed Type 1 Diabetes Mellitus Patients: Rassi D.M., Junta C.M., Fachin A.L., Sandrin–Garcia P., Mello S., Marques M.M.C., Fernandes A.P.M., Foss–Freitas M.C., Foss M.C., Sakamoto–Hojo E.T., Passos G.A.S., Donadi E.A.
27. In Vitro TNF–Α and IL–6 Production by Adherent Peripheral Blood Mononuclear Cells Obtained from Type 1 and Type 2 Diabetic Patients Evaluated According to the Metabolic Control: Maria Cristina Foss–Freitas, Norma Tiraboschi Foss, Edurado Antonio Donadi, Miltom Cesar Foss.
28. T Cell Immunity to Glutamic Acid Decarboxylase in Fulminant Type 1 Diabetes Without Significant Elevation of Serum Amylase: Kanemi Aoki MD, Matsuo Taniyama MD, Chieko Nagayama MD, Yoichi Oikawa MD, Akira Shimada MD.
29. Expression Levels of CXC Chemokine Receptors 3 are Associated with Clinical Phenotype of Type 1 Diabetes: Satoru Yamada, Yoichi Oikawa, Gen Sakai, Yoshihito, Atsumi, Taro Maruyama, Akira Shimada.
30. HLA Class I Epitope Discovery in Type 1 Diabetes: Peter Van Endert, Yousra Hassainya, Vivian Lindo, Jean–Marie Bach, Philippe Blancou, Francois Lemonnier, Roberto Mallone.
31. Up Regulation of FOXP3 Expression in Mouse and Human TREG IS IL–2/STAT5 Dependent; Implications for the NOD STAT5B Mutation in Diabetes Pathogenesis: Matthew R. Murawski, S.A. Litherland, M.J: Clare–