Autoimmune Diseases and Treatment: Organ–Specific and Systemic Disorders, Volume 1051

Only in very recent times have therapies been developed that are specific to a particular manifestation of autoimmune disease, and these have begun to replace the all–purpose remedies of the past 30 years. This volume, which draws on the principles of immunology presented in Volume 1050 (Autoimmunity: Concepts and Diagnosis at the Cutting Edge), extends these concepts to the realm of clinical findings and current therapy for many autoimmune and connective tissue disorders.
Both organ–specific and organ–nonspecific diseases are covered, and one section is entirely focused on treatment. Treatments using cytokines, chemokines, cognate receptors, and genetic interactions are particularly prominent in these reports, and attention is also paid to the increasing use of intravenous imunoglobulins and both monoclonal and imunosuppressive agents. A therapeutic void remains, but the work reported on here contributes considerably to the effort to fill that void.
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Spis treści:
Foreword: Yehuda Shoenfeld and M. Eric Gershwin.
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Part I: Organ–Specific Autoimmune Diseases:.
1. Activation, Apoptosis, and Clearance of Neutrophils in Wegener′s Granulomatosis: André P. van Rossum, Pieter C. Limburg, and Cees G. M. Kallenberg.
2. Is PR3–ANCA Formation Initiated in Wegener′s Granulomatosis Lesions? Granulomas as Potential Lymphoid Tissue Maintai ning Autoantibody Production: J Voswinkel, A Müller, and P Lamprecht.
3. Clinical Relevance of Antiphospholipid Antibodies in Primary Biliary Cirrhosis: Philipp von Landenberg, Michael Baumgartner, Juergen Schoelmerich, Karl J. Lackner, and Reinhild Klein.
4. IL–10 and the Cytokine Network in the Pathogenesis of Human Autoimmune Hemolytic Anemia: Caterina Toriani–Terenzi and Enzo Fagiolo.
5. Crohn′s Disease Is Associated with Polymorphism of CARD15/NOD2 Gene in a Hungarian Population: Zsuzsanna Nagy, Oszkár Karádi, György Rumi, György Rumi, Jr., Alajos Pár, Gyula Mózsik, László Czirják, and Gábor Süto.
6. Apoptosis in Human Skin: Role in Pathogenesis of Various Diseases and Relevance for Therapy: Esther Reefman, Pieter C. Limburg, Cees G. M. Kallenberg, and Marc Bijl.
7. Cancer–Associated Myositis: Clinical Features and Prognostic Signs: Andrea Ponyi, Tamás Constantin, Miklós Garami, Csilla andrás, Béla Tállai, Andrea Váncsa, Lajos Gergely, and Katalin Dankó.
8. Control of Type 1 Autoimmune Diabetes by Naturally Occurring CD4+CD25+ Regulatory T Lymphocytes in Neonatal NOD Mice: C A Piccirillo, M Tritt, E Sgouroudis, A Albanese, M Pyzik, and V Hay.
9. The Role of Methallothioneins in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis: Carmen Espejo and Eva M. Martínez–Cáceres.
10. Oxidized Low–Density Lipoprotein/ß2–Glycoprotein I Complexes and Autoantibodies in Patients with Type 2 Diabetes Mellitus: Luis R. Lopez, Beth L. Hurley, Daniel F. Simpson, and Eiji Matsuura.
11. Autoantibodies to Human 6 Integrin in Patients with Bullous Pemphigoid: Mária Kiss, Ádám Perényi, Ilona Marczinovits, János Molnár, Attila Dobozy, Lajos Kemény, and Sándor Husz.
12. Soluble HLA Class I and Class II Molecules in Relapsing–Remitting Multiple Scl erosis: Acute Response to Interferon–ß1a Treatment and Their Use as Markers of Disease Activity: Alireza Minagar, Irena Adamashvilli, Stephen L. Jaffe, Michael F. Glabus, Eduardo Gonzalez–Toledo, and Roger E. Kelley.
13. Proinflammatory Cytokines and Autoimmunity in Churg–Strauss Syndrome: B Hellmich, E Csernok, and W L Gross.
14. Rheumatic Fever: How S. pyogenes–Primed Peripheral T Cells Trigger Heart Valve Lesions: L Guilherme, K C Faé, S E Oshiro, A C Tanaka, P M A Pomerantzeff, and J Kalil.
15. Avidity of Anti–ß2–Glycoprotein I and Thrombosis or Pregnancy Loss in Patients with Antiphospholipid Syndrome: S Cucnik, B Bozic, T Kveder, M Tomsic, and B Rozman.
16. Neurological Complications of Celiac Disease and Autoimmune Mechanisms: Preliminary Data of a Prospective Study in Adult Patients: C Briani, G Zara, E Toffanin, S Ruggero, A Ferrarini, F De Lazzari, M Luca, D Faggian, F Grassivaro, M Ermani, R Pezzani, B Giometto, and A D′odorico.
17. E2F1–/– C57BL/6 Mice Overexpressing a Human Bcl–2 Transgene in B Cells Develop a Mild Autoimmune Syndrome: María J. Marín, Itxaso García, Marta Peña, Ainhoa Bolívar, Ana Zubiaga, and Marcos Lóez–Hoyos.
18. Systemic Thromboembolism in Inflammatory Bowel Disease: Mechanisms and Clinical Applications: Gilad Twig, Gisele Zandman–Goddard, Martine Szyper–Kravitz, and Yehuda Shoenfeld.
19. Pregnancy Loss and Endometriosis: Pathogenic Role of Anti–Laminin–1 Autoantibodies: Junko Inagaki, Akane Kondo, Luis R. Lopez, Yehuda Shoenfeld, and Eiji Matsuura.
20. Primary Biliary Cirrhosis: Solving the Enigma: Alessia Giorgini, Carlo Selmi, Pietro Invernizzi, Mauro Podda, Massimo Zuin, and M Eric Gershwin.
21. The Stages of Type 1A Diabetes: Naru Babaya, Maki Nakayama, and George S. Eisenbarth.
22. Soluble CD40L in Plasma of Patients with Primary Biliary Cirrhosis: Sabine Oertelt, Pietro Invernizzi, Carlo Selmi, Mauro Podda, and M Eric Gershwin.
23. Decreased Serum Leptin Levels in Primary Biliary Cirrhosis: A Link between Metabolism and Autoimmunity?: Roman Rieger, Sabine Oertelt, Carlo Selmi, Pietro Invernizzi, Mauro Podda, and M Eric Gershwin.
24. Analysis of the Foxp3/Scurfin Gene in Crohn′s Disease: Ogyi Park, Irina Grishina, Patrick S. Leung, M Eric Gershwin, and T Prindiville.
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Part II: Systematic Autoimmune Diseases:.
25. Juvenile Systemic Sclerosis: A Follow–up Study of Eight Patients: Szilvia Szamosi, László Maródi, László Czirják, Zoltán Ellenes, and Gabriella Szücs.
26. Antifodrin Antibodies in Sjögren′s Syndrome: A Review: Torsten Witte.
27. Generation and Characterization of Three Monoclonal IgM Antiphospholipid Antibodies Recognizing Different Phospholipid Antigens: Catharina Buschmann, Christian Fischer, Viola Ochsenhirt, Carolin Neukirch, Karl J. Lackner, and Philipp von Landenberg.
28. Premature Immunosenescence in Rheumatoid Arthritis and Multiple Sclerosis Patients: Marielle Thewissen, Loes Linsen, Veerle Somers, Piet Geusens, Jef Raus, and Piet Stinissen.
29. Association of Rheumatoid Arthritis with HLA–DR1 and HLA–DR4 in Hungary: Anikó Kapitány, Erika Zilahi, Sándor Szántó, Gabriella Szücs, Zoltán Szabó, Anikó Végvári, Péter Rass, Sándor Sipka, Gyula Szegedi, and Zoltán Szekanecz.
30. Plasminogen Activator Inhibitor–1 Is Associated with Impaired Endothelial Function in Women with Systemic Lupus Erythematosus: Emily C. Somers, Wendy Marder, Mariana J. Kaplan, Robert D. Brook, and W Joseph McCune.
31. Early Atherosclerosis in Rheumatoid Arthritis: Effects of Smoking on Thickness of the Carotid Artery Intima Media: Roberto Gerli, Yaniv Sherer, Gaetano Vaudo, Giuseppe Schillaci, Boris Gilburd, andrea Giordano, Elena Bartoloni Bocci, R