The Role of Mitochondria in Human Aging and Disease: From Genes to Cell Signaling, Volume 1042

Virtually every aspect of mitochondrial research and medicine is addressed in this volume, including mitochondrial function and dysfunction, free radical biology relevant to mitochondrial dysfunction, the role of mitochondria in apoptosis, and abnormal signaling processes and disease mechanisms associated with aging, mtDNA mutations, or mitochondrial damage.
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Spis treści:
Preface: Yau–Huei Wei, Horng–Mo Lee, and Chung Y. Hsu.
Part I: Mitochondrial Disease Models:.
1. Mitochondria–Based Model for Fetal Origin of Adult Disease and Insulin Resistance: Hong Kyu Lee, Kyong Soo Park, Young Min Cho, Yun Yong Lee, and Youngmi Kim Pak.
2. Evolutional Analysis in Determining Pathogenic versus Nonpathogenic Mutations of ATPase 6 in Human Mitochondriopathy: Chin–Yuan Tzen and Tsu–Yen Wu.
3. Restoration of Mitochondrial Function in Cells with Complex I Deficiency: Yidong Bai, Jeong Soon Park, Jian–Hong Deng, Youfen Li, and Peiqing Hu.
4. Hearing Loss in Mitochondrial Disorders: Chang–Hung Hsu, Haeyoung Kwon, Cherng–Lih Perng, Ren–Kui Bai, Pu Dai, and Lee–Jun C. Wong.
5. Brain Single Photon Emission Computed Tomography in Patients with A3243G Mutation in Mitochondrial DNA tRNA: Peterus Thajeb, Ming–Che Wu, Bing–Fu Shih, Chin–Yuan Tzen, Ming–Fu Chiang, and Rey–Yue Yuan.
6. Upregulation of Matrix Me talloproteinase 1 and Disruption of Mitochondrial Network in Skin Fibroblasts of Patients with MERRF Syndrome: Yi–Shing Ma, Yin–Chiu Chen, Ching–You Lu, Chun–Yi Liu, and Yau–Huei Wei.
7. Increased Oxidative Damage with Altered Antioxidative Status in Type 2 Diabetic Patients Harboring the 16189 T to C Variant of Mitochondrial DNA: Tsu–Kung Lin, Shang–Der Chen, Pei–Wen Wang, Yau–Huei Wei, Cheng–Feng Lee, Tzu–Ling Chen, Yao–Chung Chuang, Teng–Yeow Tan, Ku–Chou Chang, and Chia–Wei Liou.
8. Alteration of the Copy Number of Mitochondrial DNA in Leukocytes of Patients with Hyperlipidemia: Chin–San Liu, Ching–Ling Kuo, Wen–Ling Cheng, Ching–Shan Huang, Cheng–Feng Lee, and Yau–Huei Wei.
9. A New Noninvasive Test to Detect Mitochondrial Dysfunction of Skeletal Muscles in Progressive Supranuclear Palsy: Yung–Yee Chang, Chiang–Hsuan Lee, Min–Yu Lan, Hsiu–Shan Wu, Chiung–Chih Chang, and Jia–Shou Liu.
10. High Prevalence of the COII/tRNALys Intergenic 9–bp Deletion in Mitochondrial DNA of Taiwanese Patients with MELAS or MERRF Syndrome: Chin–San Liu, Wen–Ling Cheng, Yi–Yun Chen, Yi–Shing Ma, Cheng–Yoong Pang, and Yau–Huei Wei.
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Part II: Mitochondrial Genome:.
11. Analysis of Proteome Bound to D–Loop Region of Mitochondrial DNA by DNA–Linked Affinity Chromatography and Reverse–Phase Liquid Chromatography/Tandem Mass Spectrometry: Yon–Sik Choi, Bo–Kyung Ryu, Hye–Ki Min, Sang–Won Lee, and Youngmi Kim Pak.
12. Mitochondrial Transcription Factor A in the Maintenance of Mitochondrial DNA: Overview of Its Multiple Roles: Dongchon Kang and Naotaka Hamasaki.
13. Mitochondrial Genome Instability and mtDNA Depletion in Human Cancers. By Hsin–Chen Lee, Pen–Hui Yin, Jin–Ching Lin, Cheng–Chun g Wu, Chih–Yi Chen, Chew–Wun Wu, Chin–Wen Chi, Tseng–Nip Tam, and Yau–Huei Wei.
14. Frequent Occurrence of Mitochondrial Microsatellite Instability in the D–Loop Region of Human Cancers: Yue Wang, Vincent W.S. Liu, Hextan Y.S. Ngan, and Phillip Nagley.
15. Analysis of Heteroplasmy in Hypervariable Region II of Mitochondrial DNA in Maternally Related Individuals: Mei–Chen Lo, Horng–Mo Lee, Ming–Wei Lin, and Chin–Yuan Tzen.
16. Deleted Mitochondrial DNA in Human Luteinized Granulosa Cells: Heng–Kien Au, Shyh–Hsiang Lin, Shih–Yi Huang, Tien–Shun Yeh, Chii–Ruey Tzeng, and Rong–Hong Hsieh.
17. Identification of Human–Specific Adaptation Sites of ATP6: Bey–Liing Mau, Horng–Mo Lee, and Chin–Yuan Tzen.
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Part III: Mitochondrial Function:.
18. Repeated Ovarian Stimulations Induce Oxidative Damage and Mitochondrial DNA Mutations in Mouse Ovaries: Hsiang–Tai Chao, Shu–Yu Lee, Horng–Mo Lee, Tien–Ling Liao, Yau–Huei Wei, and Shu–Huei Kao.
19. Calcium Stimulates Mitochondrial Biogenesis in Human Granulosa Cells: Tien–Shun Yeh, Jau–Der Ho, Vivian Wei–Chung Yang, Chii–Ruey Tzeng, and Rong–Hong Hsieh.
20. Dynamics of Mitochondria and Mitochondrial Ca2+ near the Plasma Membrane of PC12 Cells: A Study by Multimode Microscopy: De–Ming Yang, Chung–Chih Lin, Hsia Yu Lin, Chien–Chang Huang, Din Ping Tsai, Chin–Wen Chi, and Lung–Sen Kao.
21. Propofol Specifically Inhibits Mitochondrial Membrane Potential but Not Complex I NADH Dehydrogenase Activity, Thus Reducing Cellular ATP Biosynthesis and Migration of Macrophages: Gong–Jhe Wu, Yu–Ting Tai, Ta–Liang Chen, Li–Ling Lin, Yune–Fang Ueng, and Ruei–Ming Chen.
22. Abnormal Mitochondrial Structure in Human Unfertilized Oocytes and Arrested Embryos: Heng 211;Kien Au, Tien–Shun Yeh, Shu–Huei Kao, Chii–Ruey Tzeng, and Rong–Hong Hsieh.
23. Oxidative Damage and Mitochondrial DNA Mutations with Endometriosis: Shu–Huei Kao, Hsieng–Chiang Huang, Rong–Hong Hsieh, Su–Chee Chen, Ming–Chuan Tsai, and Chii–Reuy Tzeng.
24. Neuroprotective Role of Coenzyme Q10 against Dysfunction of Mitochondrial Respiratory Chain at Rostral Ventrolateral Medulla during Fatal Mevinphos Intoxication in the Rat: F C.H. LI, H P TSENG, and A Y.W. Chang.
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Part IV: Oxidative Stress:.
25. Mitochondrial Dysfunction and Oxidative Stress as Determinants of Cell Death/Survival in Stroke: Pak H. Chan.
26. Oxidative Damage in Mitochondrial DNA Is Not Extensive: Kok Seong Lim, Kandiah Jeyaseelan, Matthew Whiteman, andrew Jenner, and Barry Halliwell.
27. Enhanced Generation of Mitochondrial Reactive Oxygen Species in Cybrids Containing 4977–bp Mitochondrial DNA Deletion: Mei–Jie Jou, Tsung–I Peng, Hong–Yueh Wu, and Yau–Huei Wei.
28. S–Nitrosoglutathione and Hypoxia–Inducible Factor–1 Confer Chemoresistance against Carbamoylating Cytotoxicity of BCNU in Rat C6 Glioma Cells: Ding–I Yang, Shang–Der Chen, Jiu–Haw Yin, and Chung Y. Hsu.
29. Celecoxib Induces Heme–Oxygenase Expression in Glomerular Mesangial Cells: Chun–Cheng Hou, Su–Li Hung, Shu–Huei Kao, Tso Hsiao Chen, and Horng–Mo Lee.
30. Oxidative Stress–Induced Depolymerization of Microtubules and Alteration of Mitochondrial Mass in Human Cells: Cheng–Feng Lee, Chun–Yi Liu, Rong–Hong Hsieh, and Yau–Huei Wei.
31. Blood Lipid Peroxides and Muscle Damage Increased following Intensive Resistance Training of Female Weightlifters: Jen–Fang Liu, Wei–Yin Chang, Kuei–Hui Chan, Wen–Yee Tsai, Chen–Li Lin, and Mei–Chieh Hsu.
32. Anti–Inflammatory and Ant