Stem Cell Biology: Development and Plasticity, Volume 1049

Cover art: Various cell surface receptors mediate an intimate dialogue between stem cells and their environment and can modulate the behavior of both in decisive ways. The over–expression of such molecules in neural stem cells can lead to elaborate neurite outgrowth from differentiating neurons. The examples shows a large neuron (body size over 30 um) in culture over–expressing the neural cell recognition molecule L1 and communicating with other cellular partners. Nuclei of cultured cells are visualized by the fluorescent marker DAPI (blue) and the neurons by immunofluorescent staining against the early neuronal antigen BIII–tubulin (red). Microphotograph taken by Dr. Ying–Zhi Xu from the Ourednik Lab of Stem Cell Plasticity and Neural Transplantation, Iowa State University, Ames, Iowa.

Spis treści:
Preface: Jitka Ourednik, Václav Ourednik, Donald Sakaguchi, and Marit Nilsen–Hamilton.
Part I: Regional Determinants of Cell Fate:.
1. Oxygen in the Cultivation of Stem Cells. By Marie Csete.
2. DNA Damage–Induced Programmed Cell Death: Potential Roles in Germ Cell Development. By Yukiko Yamada and Clark R. Coffman.
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Part II: Intrinsic Determinants of Stem Cells:.
3. G Protein–Coupled Receptor Roles in Cell Migration and Cell Death Decisions: Angela R. Kamps and Clark R. Coffman.
4. Growth and Differentiation of Astrocytes and Neural Progenitor Cells on Micropatterned Polymer Films: Jennifer B. Recknor, D S. Sakaguchi, and S K. Mallapragada.
5. Cellular and Molecular Regulation of Hematopoietic and Intestinal Stem Cell Behavior: Xi C. He, Jiwang Zhang, and Linheng Li.
6. The Function of the Neuronal Proteins Shc and Huntingtin in Stem Cells and Neurons: Pharmacologic Exploitation for Human Brain Diseases: Chiara Zuccato, Luciano Conti, Erika Reitano, Marzia Tartari, and Elena Cattaneo.
7. Engineering a Dopaminergic Phenotype in Stem/Precursor C ells: Role of Nurr1, Glia–Derived Signals, and Wnts: Ernest Arenas.
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Part III: Transdifferentiation:.
8. Umbilical Cord Blood–Derived Stem Cells and Brain Repair: Paul R. Sanberg, Alison E. Willing, Svitlana Garbuzova–Davis, Samuel Saporta, Guoqing Liu, Cyndy Davis Sanberg, Paula C. Bickford, Stephen K. Klasko, and Nagwa S. El–Badri.
9. Infusion of Human Umbilical Cord Blood Ameliorates Neurologic Deficits in Rats with Hemorrhagic Brain Injury: Zhenhong Nan, andrew Grande, Cyndy D. Sanberg, Paul R. Sanberg, and Walter C. Low.
10. How Wnt Signaling Affects Bone Repair by Mesenchymal Stem Cells from the Bone Marrow: Carl A. Gregory, William G. Gunn, Emigdio Reyes, Angela J. Smolarz, James Munoz, Jeffrey L. Spees, and Darwin J. Prockop.
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Part IV: Stem Cell Responses to Perturbation:.
11. Human Retinal Progenitor Cells Grown as Neurospheres Demonstrate Time–Dependent Changes in Neuronal and Glial Cell Fate Potential: David M. Gamm, Aaron D. Nelson, and Clive N. Svendsen.
12. Neural Progenitor Cell Transplants into the Developing and Mature Central Nervous System: D S. Sakaguchi, S J. Van Hoffelen, S D. Grozdanic, Y H. Kwon, R H. Kardon, and M J. Young.
13. Stem Cells for Retinal Degenerative Disorders: Jason S. Meyer, Martin L. Katz, and Mark D. Kirk.
14. Magnetic Resonance Tracking of Implanted Adult and Embryonic Stem Cells in Injured Brain and Spinal Cord: Eva Syková and Pavla Jendelová.
15. The Miniature Pig as an Animal Model in Biomedical Research: Petr Vodicka, Karel Smetana, Jr., Barbora Dvoránková, Teresa Emerick, Yingzhi Z. Xu, Jitka Ourednik, Václav Ourednik, and Jan Motlík.
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Part V: Reciprocal Communication between Graft and Host:.
16. Graft/Host Relationships in the Developing and Regenerating CNS of Mammals: Václav Ourednik and Jitka Ourednik.
17. Grafted Neural Stem Cells Shield the Host Environment from Oxidative Stres s: Lalitha Madhavan, Václav Ourednik, and Jitka Ourednik.
18. Administration of Allogenic Stem Cells Dosed to Secure Cardiogenesis and Sustained Infarct Repair: Atta Behfar, Denice M. Hodgson, Leonid V. Zingman, Carmen Perez–Terzic, Satsuki Yamada, Garvan C. Kane, Alexey E. Alekseev, Michel Pucéat, and andre Terzic.
Index of Contributors

Okładka tylna:
Cover art: Various cell surface receptors mediate an intimate dialogue between stem cells and their environment and can modulate the behavior of both in decisive ways. The over–expression of such molecules in neural stem cells can lead to elaborate neurite outgrowth from differentiating neurons. The examples shows a large neuron (body size over 30 um) in culture over–expressing the neural cell recognition molecule L1 and communicating with other cellular partners. Nuclei of cultured cells are visualized by the fluorescent marker DAPI (blue) and the neurons by immunofluorescent staining against the early neuronal antigen BIII–tubulin (red). Microphotograph taken by Dr. Ying–Zhi Xu from the Ourednik Lab of Stem Cell Plasticity and Neural Transplantation, Iowa State University, Ames, Iowa.