Micro- and Nanoengineering of the Cell Surface

Micro- and Nanoengineering of the Cell Surface explores the direct engineering of cell surfaces, enabling materials scientists and chemists to manipulate or augment cell functions and phenotypes. The book is accessible for readers across industry, academia, and in clinical settings in multiple disciplines, including materials science, engineering, chemistry, biology, and medicine. Written by leaders in the field, it covers numerous cell surface engineering methods along with their current and potential applications in cell therapy, tissue engineering, biosensing, and diagnosis.

The interface of chemistry, materials science, and biology presents many opportunities for developing innovative tools to diagnose and treat various diseases. However, cell surface engineering using chemistry and materials science approaches is a new and diverse field. This book provides a full coverage of the subject, introducing the fundamentals of cell membrane biology before exploring the key application areas.

Demystifies the direct engineering of cell surfaces, enabling materials scientists and chemists to manipulate or augment cell functions and phenotypesProvides a toolkit of micro- and nanoengineering approaches to the manipulation of the cell surfaceUnlocks the potential of cell surface manipulation for a range of new applications in the fields of in vitro research, cell therapy, tissue engineering, biosensing, and diagnostics

1 - Cell membrane engineering: an introduction
2 - Cell membrane biology
3 - Cell Surface Engineering by Chemical Reaction and Remodeling
4 - Noncovalent approaches
5 - liposome fusion
6 - fatty acid, GPI and cholesterol anchors
7 - Engineering the surface of cells using the biotin-avidin interaction
8 - Cell microencapsulation for tissue engineering and regenerative medicine
9 - glycosylphosphatidyl inositol (GPI), cholesterol anchors, palmitated protein A/G (hydrophobic), Protein painting/transfer, tethered ligands
10 - Recent advances in bioconjugation of living cells and their applications in metabolic oligosaccharide engineering.
11 -bio-orthogonal chemistry at cell surfaces
12 - Cell surface enzymatic engineering-based approaches to improve cell therapies
13 - Strategies for incorporation of biological cues into synthetic hydrogels
14 - Nanoparticle/cell interfacing, Control the stability of functioned (nano)materials on the cell surface: consideration and factors
15 - Study/imaging of cell surface engineering; tools for study cell-materials interface
16 - Cell surface/nanoparticle interfacing to manipulate cell fate
17 - Pushing the bacterial envelope: Genetic strategies for re-engineering bacterial surfaces with heterologous proteins and sugars
18 - Use of surface engineering for in vitro research tools and reagents
19 - Nucleic acids as nanoscale cellular patches
20 - Molecular Engineering of Cell and Tissue Surfaces with Polymer Thin Films
21 - Considerations for manufacturing surface modified cells for cell therapy applications, Challenges, regulatory, scale up, future