The Metabolic Syndrome

The Metabolic Syndrome is a valuable reference text, covering all aspects of the metabolic syndrome and its constituent diseases including inflammation, oxidation and adipocytokines. This book explains the aetiology, pathogenesis and clinical treatment of all risk factors as well as the relationship with diabetes, non–alcoholic fatty liver disease, polycystic ovary syndrome and coronary heart disease. The Metabolic Syndrome has been further improved from the 1st edition that was highly commended in 2006 Annual British Medical Association medical books competition. All chapters from the first edition are fully updated and this new edition contains an increase in international contributions and five new chapters on: • Childhood obesity and metabolic syndrome • Bariatric surgery for obesity • Fitness • Brain insulin resistance and appetite • The nature of the insulin resistance seen in metabolic syndrome. This brand new edition of The Metabolic Syndrome will be an indispensable resource for all clinical researchers, physicians and scientists requiring detailed up–to–date information on the metabolic syndrome to further their own research or to treat and manage the syndrome and its complications. Specifically, the text will be of particular relevance to those involved and working in the fields of diabetes, endocrinology, obesity, cardiology, vascular disease and hepatology.

List of Contributors. Foreword. Preface. 1 The Epidemiology of the Metabolic Syndrome and its Association with Diabetes, Cardiovascular Disease and Other Conditions ( Sarah H. Wild and Christopher D. Byrne ). 2 Metabolic Syndrome and Ethnicity ( Thérèse Tillin and Nita G. Forouhi ). 3 Developmental Origins of Endothelial Dysfunction: A Key Step in Cardiometabolic Disease ( Christopher Torrens, Geraldine F. Clough and Mark A Hanson ). 4 Developmental Origins of Insulin Resistance and Type 2 Diabetes ( Susan E. Ozanne and Kenneth Siddle ). 5 The Metabolic Syndrome in Children ( Ram Weiss and Sonia Caprio ). 6 Assessment of Insulin Sensitivity ( Julia Szendroedi, Esther Phielix and Michael Roden ). 7 Recent Progress in Identifying Genes Contributing to Type 2 Diabetes ( Weijia Xie, Timothy M Frayling and Michael N Weedon ). 8 Endocrine Aspects of the Metabolic Syndrome ( Richard I.G. Holt and Peter Sönksen ). 9 Brain Insulin Resistance ( Katharine F Hunt, Yee Seun Cheah and Stephanie A Amiel ). 10 Cardiorespiratory Fitness and the Metabolic Syndrome ( Paul A. McAuley and Steven N. Blair ). 11 Metabolic Syndrome and Mental Illness ( Richard I.G. Holt and Robert C Peveler ). 12 Atherothrombosis and the Metabolic Syndrome ( Kristina F Standeven and Peter J Grant ). 13 Inflammation and Metabolic Syndrome ( Sridevi Devaraj, David Siegel and Ishwarlal Jialal ). 14 Adipocytokine Dysregulation, Obesity and the Metabolic Syndrome ( Ulf Smith and Xiaolin Yang ). 15 Non Alcoholic Fatty Liver Disease ( Mohammed H. Ahmed and Christopher D. Byrne ). 16 Polycystic Ovary Syndrome ( Naveed Sattar ). 17 Nutrition: Its Relevance in Development and Treatment of the Metabolic Syndrome ( Jim Mann and Lisa Te Morenga ). 18 Non–Surgical Treatments for the Metabolic Syndrome ( Markolf Hanefeld U Schatz, and Frank Schaper ). 19 Metabolic/Bariatric Surgery Therapy for the Metabolic Syndrome ( Henry Buchwald ).

Christopher Byrne trained as a physician and clinical scientist at Cardiff, Cambridge and Stanford Universities. After Medical Research Council clinical science fellowships he was appointed Professor of Endocrinology & Metabolism at Southampton University Hospitals Trust, UK. He is an academic diabetologist with clinical and molecular research interests in the pathogenesis of the metabolic syndrome, and the mechanisms linking metabolic syndrome with type 2 diabetes and cardiovascular disease. His publications span a range of disciplines from epidemiological to gene expression studies. He has had 112 articles published (PubMed) Sarah Wild trained in medicine in London and Cambridge and subsequently received training in epidemiology at Stanford University and the London School of Hygiene and Tropical Medicine. She is currently senior lecturer in epidemiology at the University of Edinburgh. Her research interests include the global burden of diabetes and metabolic syndrome and cardiovascular epidemiology.She has had 31 articles published (PubMed)

"It′s rare to find an academic book as engaging as this one. While clearly focused on a specific disease entity, the magnitude of the metabolic disease epidemic coupled with the comprehensive review of the topic this book delivers, should make it interesting reading to a diverse audience." (Doody′s, 3 February 2012) "This excellent book must be considered the flagship text in the Wiley series encompassing obesity, diabetes and insulin resistance." (Practical Diabetes, 2011) "In all, the text provides a valuable summary of current knowledge, and it may even convince doubters of the existence of the metabolic syndrome! The information that is provided will be of considerable interest to both applied scientists and clinicians who study and treat the epidemics of physical inactivity and obesity that currently afflict so many countries." (Faculty of Physical Education & Health, 2011)