UICC Manual of Clinical Oncology

The Manual of Clinical Oncology, Ninth Edition, published with the International Union Against Cancer (UICC), provides a concise, accessible and feasible reference covering state of art multidisciplinary clinical oncology in order to meet the needs of clinicians caring for cancer patients throughout the world.

Edited by world–renowned practising oncologists and written by key opinion leaders, this book contains authoritative and up–to–date information on cancer detection, diagnosis and treatment alongside topics such as survivorship, special populations and palliative care.

Remodelled and revised for the ninth edition to provide practical information to oncology workers, the UICC Manual of Clinical Oncology is structured in two parts. Part 1 covers general principles of cancer diagnosis and management with additional attention to special settings in oncology, including supportive care and survivorship, and Part 2 covers site–specific multidisciplinary cancer management. The edition includes up–to–date summaries of all treatment modalities (medical, surgical and radiation) for all tumour sites. It also contains the latest TNM classifications outlined in the new edition of TNM Classification of Malignant Tumours.

The ninth edition includes

Practical presentation with bullet points, tables, and flow charts intended to facilitate quick reference for day–to–day clinical practice in busy oncology environments, Representation of multidisciplinary care for site specific management, Evidence–based approaches to management, including specific treatment recommendations and investigations guided by clinical practice guidelines, State of art evidence–based recommendations that take into consideration the lack of availability of certain medications or resources, as well as practice variations, in different and remote regions of the world, and Contemporary topics on cancer treatment, such as cancer informatics, evidence levels, principles of prognostication, survivorship and cancer in pregnancy.
Oncologists, oncologists–in–training, nurses working with cancer patients and other health professionals responsible for treating and caring for those with cancers will find the UICC Manual of Clinical Oncology an indispensable and comprehensive resource.

Foreword Preface About the Editors Contributors Residual tumor (R) classification Part 1 General principles of cancer diagnosis and management Principles of management 1 Cancer epidemiology Rajesh Dikshit and Preetha Rajaraman [M1]   2 Levels of evidence, guidelines and standards R. Bryan Rumble and Melissa C. Brouwers 3 Prognosis and classification of cancer Brian O′Sullivan, James Brierley and Mary Gospodarowicz 4 Principles of cancer staging Leslie Sobin, James Brierley, Mary Gospodarowicz, Brian O Sullivan and Christian Wittekind 5 Assessment of treatment outcome Judi Manola, Wei Xu and Bruce J. Giantonio 6 Cancer informatics David Jaffray, Andrew Hope, Terry Michaelson, Prateek Dwivedi and Andre Dekker Principles of cancer diagnosis 7 Imaging Supreeta Arya, Venkatesh Rangarajan and Nilendu Purandare 8 Pathology Joanna Chan, Rossitza Draganova–Tacheva, Wei Jiang, Zi–Xuan Wang and Stephen Peiper Principles of treatment 9 Principles of surgery Matthew Katz and Brian Bednarski 10 Principles of radiotherapy Vincent Gregoire, Cai Grau, Karin Haustermans, Ludvig Paul Muren and Fiona Stewart 11 Principles of systemic therapy Martin F. Fey and Stefan Aebi Special settings, supportive care and survivorship 12 Treatment in pregnancy Hatem A. Azim, Fedro A. Peccatori, Isabel Demeestere, Oreste Gentilini and Nicholas Pavlidis 13 Treatment in the elderly Matti Aapro 14 Oncology emergencies Jonathan King, Dustin Deming and H. Ian Robins 15 Supportive care during curative treatment Susan Urba, Suzette Walker, Danielle Karsies, Dawna Allore, Claire Casselman and Maria Almond 16 Pain management P. N. Jain and Sumitra Bakshi 17 Palliative care Mary Ann Muckaden 18 Survivorship Jennifer M. Jones, Felicia Knaul, Meredith Giuliani, Danielle Rodin and Pamela Catton 19 Rehabilitation Theresa Gillis and Kerry Tobias Part 2 Site–specific multidisciplinary cancer management Thoracic malignancies 20 Lung Suresh S. Ramalingam, Felix Fernandez, Kristin A. Higgins, William F. Auffermann and Fadlo R. Khuri Breast 21 Breast Ivo A. Olivotto, Caroline Lohrisch and Christopher Baliski Gastrointestinal malignancies 22 Liver Eddie K. Abdalla, Emile Brihi and Hady Ghanem 23 Biliary tract and pancreas 23.1 Biliary tract Rory L. Smoot, Christopher L. Hallemeier,Robert R. McWilliamsand Mark J. Truty 23.2 Pancreas Rory L. Smoot, Christopher L. Hallemeier,Robert R. McWilliamsand Mark J. Truty 24 Oesophagus Wentao Fang, Zhigang Li, Teng Mao, Jun Liu and Xufeng Guo 25 Stomach Takeshi Sano, Savtaj Brar, James Brierley and Jan Vermorken 26 Colon, rectum and anus 26.1 Colon and rectum Rob Glynne–Jones, Gina Brown, Ian Chau and Brendan J. Moran 26.2 Anus Rob Glynne–Jones, Gina Brown, Ian Chau and Brendan J. Moran Genitourinary malignancies 27 Prostate Malcolm Mason, Howard Kynaston and Robert Jones 28 Bladder and other urothelium Gillian M. Duchesne, Shomik Sengupta and Ian D. Davis 29 Kidney J. E. Ferguson III, W. Kimryn Rathmell and Eric M. Wallen 30 Testis Christian Winter, Anja Lorch, Carsten Bokemeyer, Heinz Schmidberger and Peter Albers 31 Penis Juanita Crook, Lance Pagliaro and Curtis Pettaway Haematological malignancies 32 Lymphoma Richard W. C. Tsang and Michael Crump 33 Myeloma J. San Miguel, P. Rodríguez–Otero , E. Ocio, B. Paiva, N. Gutierrez and M. V. Mateos 34 Leukaemia Tsila Zuckerman and Jacob M. Rowe Gynaecological cancers 35 Cervix Lynette Denny and Leon Van Wijk 36 Uterus G. Kristensen, V. Abeler, Kristina Lindemann and Carien L. Creutzberg 37 Ovary and fallopian tube Gemma Owens and Henry Kitchener 38 Vulva M. H. M. Oonk, E. Pras and A. G. J. van der Zee Head and neck cancer 39 General principles of head and neck cancer management Mitali Dandekar, Anil K. D Cruz, Shao Hui Huang, Brian O Sullivan and Jan B. Vermorken 40 Nasopharynx Ann W. M. Lee, W. T. Ng, Quynh–Thu Le, Anthony T. C. Chan, Jimmy Y. W. Chan and Henry C. K. Sze 41 Oral cavity Richa Vaish, Mitali Dandekar, Jai Prakash Agarwal, Kumar Prabhash and Anil K. D′Cruz 42 Larynx and hypopharynx Jai Prakash Agarwal, Tejpal Gupta, Rahul Krishnatry, Amit Joshi and Mitali Dandekar 43 Oropharynx Shao Hui Huang, Hisham Mehanna, Jan B. Vermorken and Brian O′Sullivan 44 Major salivary glands Devendra Chaukar, Abhishek D. Vaidya, Rohan Walvekar, Sarbani Ghosh–Laskar and Kumar Prabhash 45 Nasal cavity and paranasal sinus Prathamesh S. Pai, Sarbani Ghosh–Laskar, Shubhada Kane, K. Thomas Robbins, Piero Nicolai and Lisa Licitra 46 Head and neck unknown primary Sarbani Ghosh–Laskar, Naveen B. Mummudi, Vedang Murthy and Gouri Pantvaidya Endocrine tumours 47 Pituitary Sherise D. Ferguson and Ian E. McCutcheon 48 Thyroid James D. Brierley, David P. Goldstein and Monika K. Krzyzanowska 49 Adrenal gland Minerva Angélica Romero Arentumouras, Mouhammed Amir Habra and Nancy D. Perrier 50 Neuroendocrine tumours Dermot O′Toole, Laura H. Tang, Robert T. Jensen, Massimo Falconi, U.–F. Pape and Dik Kwekkeboom Dermatological cancer 51 Skin: Basal cell carcinoma, squamous cell carcinoma and Merkel cell carcinoma Sandro V. Porceddu, Michael J. Veness and H. Peter Soyer 52 Melanoma Kim Margolin, Brian O′Sullivanand Raphael Pollock Central nervous system and ocular cancers 53 Central nervous system Caroline Chung, Do–Hyun Nam and Roger Stupp 54 Eye: Choroidal melanoma, retinoblastoma, ocular adnexal lymphoma and eyelid cancers Paul T. Finger Sarcoma 55 Bone (osteosarcoma) Elizabeth J. Davis, Geoffrey Siegel, Mary Feng, J. Sybil Biermann and Rashmi Chugh 56 Soft tissue Colleen Dickie, Abha Gupta, Raphael Pollock and Brian O′Sullivan Childhood malignancies 57 Paediatric tumours Hatel Moonat, Anna R. Franklin, Andrea Hayes–Jordan, Mary F. McAleer and Winston W. Huh Specific cancer situations 58 Cancer of unknown primary (non–head and neck) George Pentheroudakis and Nicholas Pavlidis 59 HIV and transplant–related neoplasms 59.1 HIV–related neoplasms Jean–Philippe Spano, Dominique Costagliola, Sylvain Choquet, Fabrice Bonnet, Armelle Lavolle and Laurent Quéro 59.2 Post–transplantation lymphoproliferative disease Jean–Philippe Spano, Sylvain Choquet, Fabrice Bonnet, Armelle Lavolle and Laurent Quéro 59.3 Cancer after solid organ transplantation Jerome Martin Laurence Index

Brian O Sullivan, MD, FRCPC, FRCPI, FFRRCSI (Hon), FASTRO (Editor–in–Chief)

Professor, Department of Radiation Oncology

Bartley–Smith / Wharton Chair in Radiation Oncology

Princess Margaret Cancer Centre / University of Toronto

Toronto, Ontario, Canada

 

James D Brierley, BSc, MB, FRCP, FRCR, FRCPC (Associate Editor)

Professor, Department of Radiation Oncology

Princess Margaret Cancer Centre / University of Toronto

Toronto, Ontario, Canada

 

Anil K. D Cruz MS, DNB, FRCS (Associate Editor)

Professor, Department of Head and Neck Surgical Oncology

Tata Memorial Hospital, Mumbai, India

 

Martin F. Fey, MD (Associate Editor)

Professor, Department of Medical Oncology

Inselspital and University Hospital

Bern, Switzerland

 

Raphael Pollock, MD, PhD (Associate Editor)

Director of Surgical Oncology, Chief of Surgical Services

The James NCICCC/Ohio State University

Columbus, OH, USA

 

Jan B. Vermorken, MD, PhD (Associate Editor)

Emeritus Professor of Oncology

Faculty of Medicine and Health Sciences,

University of Antwerp, Antwerp, Belgium

Department of Medical Oncology

Antwerp University Hospital

Edegem, Belgium

 

 

Shao Hui Huang, MD, MSc, MRT(T) (Editorial coordinator)

Assistant Professor

Department of Radiation Oncology

Princess Margaret Cancer Centre / University of Toronto

 

 

BIOGRAPHIES

Brian O Sullivan is a Professor in the Department of Radiation Oncology at the University of Toronto, Toronto, Ontario, Canada. He also holds the Bartley–Smith/Wharton Distinguished Chair in Radiation Oncology in the Department of Radiation Oncology at the Princess Margaret Cancer Centre, University of Toronto. He is the Head and Neck Oncology Program Chair at Princess Margaret Cancer Centre, the co–Chair of the US NCI Head and Neck Steering Committee, Coordinating Center for Clinical Trials, CTEP, and a full standing member of the Commission of the International Commission on Radiation Units (ICRU). He is the recipient of numerous international awards, and research grants.  He has published almost 300 peer reviewed papers, in excess of 50 book chapters, and has written or edited 6 oncology textbooks.  His interests include sarcoma and head and neck cancer, translational research, IMRT delivery and the principles of image guided radiotherapy, chemo–radiotherapy and molecular targeting. He is a member of the TNM Committee of the Union for International Cancer Control (UICC), Chair of the UICC Prognostic Classification Sub–Committee and represents the UICC as liaison in several oncology sites to the American Joint Committee on Cancer (AJCC).

 

James Brierley is a Professor in the Department of Radiation Oncology at the University of Toronto, Princess Margaret Cancer Centre. He obtained his medical degree from Westminster Medical School, University of London. He initially did postgraduate training in Internal Medicine before transferring to Clinical Oncology. He is interested in the management of gastrointestinal malignancy and thyroid malignancy and cancer staging and surveillance. He has written extensively on thyroid cancer, the role of radiation in gastrointestinal malignancy and cancer staging and surveillance and is actively involved in research into the role of radiation in the management of gastrointestinal and endocrine malignancies and ensuring staging data is collected and used on a population basis. He is the previous head of the Gastrointestinal Site Group at the Princess Margaret Cancer Centre and is currently the Canadian Partnership Against; Cancer  Expert Lead, Staging and Surveillance. He is a Member of the AJCC Executive and Chair of the AJCC Education and Promotions Working Group,  Co–Chair of the UICC TNM Prognostic Factors Core Group and Co–Editor of the UICC 8th edition TNM Classification of Malignant Tumours.

 

Anil D Cruz is Director at the Tata Memorial Hospital, Mumbai, India as well as Professor& Surgeon, Department of Head & Neck Surgery.   He is a distinguished leader in the field of oncology and on the Board of Directors of the Union for International Cancer Control (UICC), Geneva, Foundation of Head Neck Oncology India and the Asian Society of Head Neck Oncology.. He has more than 150 peer–reviewed publications and chapters to his name and is also an editor for a two volume text book on Head and neck Surgery. He is Associate Editor of Head Neck Oncology Journal and member of the Editorial Board of many reputed national and international journals. He has delivered more than 250 invited lectures and 50 orations.

 

Martin Fey is a Professor and Head of Department of Medical Oncology at the University of Berne, Switzerland. He is also Head of the Department of Oncology, Laboratory medicine and Hospital Pharmacy at the Inselspital Bern. He received his medical degree from the Berne University Medical School. He was the recipient of Robert–Wenner Award of the Swiss Cancer League and Ellermann Award of the Swiss Society of Haematology. He has more than 250 peer–reviewed publications to his credit, mainly in clinical and experimental haematological oncology. He leads clinical trials in leukaemia, lymphoma, breast cancer and other types of tumours. He was the Chairman of the Leukaemia Group of the Swiss Group for Clinical Cancer Re¬search (SAKK) from 1990–1995 and a Principal Investigator of the SAKK and the International Breast Cancer Study Group (IBCSG) from 1993–2002. His interests include leukaemia, lymphoma, breast cancer, and the design of clinical trials. He is a member of the Cantonal Ethics Committee for Clinical Trials of the Canton of Bern, Switzerland.

 

Raphael Pollock, M.D., Ph.D. was born in Chicago, Illinois and graduated from Oberlin College, Oberlin, Ohio in 1972. This was followed by medical school at the St. Louis University School of Medicine Chicago, IL residencies in General Surgery at the University of Chicago and Rush Medical College, a fellowship in Surgical Oncology at The University of Texas M. D. Anderson Cancer Center, and a Ph.D. in Tumor Immunology from the Graduate School of the Biological Sciences at the University of Texas–Houston Health Sciences Center. Dr. Pollock joined the Department of Surgical Oncology at The University of Texas M. D. Anderson Cancer Center as a faculty member in 1984.  Dr. Pollock became Chairman of the Department of Surgical Oncology in 1993 and became Head of the Division of Surgery at The University of Texas M. D. Anderson Cancer Center in 1997. In 2006–07 Dr. Pollock served as President of the Society of Surgical Oncology; from 1999–2011 he served as Editor–in–Chief of Cancer. In 2013 Dr. Pollock left MD Anderson to become Director and Professor, Division of Surgical Oncology and Chief of Surgical Services at The James Comprehensive Cancer Center at The Ohio State University Medical Center, Columbus, Ohio. Dr. Pollock serves as Director of the Sarcoma Research Laboratory at The Ohio State University Medical Center and is the Principal Investigator on behalf of the US NIH/NCI SARC Sarcoma SPORE grant program. Dr. Pollock is a member of the US NIH/NCI Board of Scientific Counselors.

 

Jan B. Vermorken was born in 1944,  graduated in 1970 from the University of Amsterdam, the Netherlands and became a board–certified specialist in internal medicine in 1975. Since that time he has worked in the field of Medical Oncology and was officially registered as a Medical Oncologist in the Netherlands in 1992. He received his PhD in Medical Sciences in 1986 from the Vrije Universiteit in Amsterdam.  From May 1997 until October 1, 2009, he was Professor of Oncology at the University of Antwerp (UA), and head of the Department of Medical Oncology at the University Hospital Antwerp (UZA), in Edegem, Belgium. After his retirement he remains connected to both University (emeritus Professor) and University Hospital.

His main fields of interest are gynecologic oncology, and head and neck oncology. He devotes a significant amount of time to teaching, professional training, and continuing medical education.

Professor Vermorken is member of various scientific societies, is member of several editorial boards of International journals, reviewer multiple cancer journals and author or co–author of more than 500 publications in international journals. From January 1, 2009 until January 1, 2014 he was Editor–in–Chief of Annals of Oncology, the official journal of the European Society for Medical Oncology and the Japanese Society of Medical Oncology. On March 1, 2013 he received the title of Commander in the Order of Leopold for his contributions to oncology.