Human Toxicology of Chemical Mixtures

In this important reference work, Zeliger catalogs the known effects of chemical mixtures

on the human body and also proposes a framework for understanding and predicting their

actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The

author’s focus is on illnesses that ensue following exposures to mixtures of chemicals

that cannot be attributed to any one component of the mixture.

In the first part the mechanisms of chemical absorption at a molecular and

macromolecular level are explained, as well as the body’s methods of defending itself

against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed,

looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which

includes numerous case studies, examines specific effects of particular mixtures on

particular body systems and organs and presents a theoretical framework for predicting

what the effects of uncharacterized mixtures might be. Part IV covers regulatory

requirements and the need to adjust recommended exposure levels for products

containing mixtures. It also contains recommendations on how to limit exposure to

mixtures in the products we use and on how to limit release of mixtures into the

environment.

Providing brief summaries of each mixture and its effects, Zeliger provides a

comprehensive reference, a jumping off point for professionals (with extensive chapter

bibliographies) and an introduction to the topic for those studying traditional toxicology.

Addressing many inadequately understood illnesses and conditions such as asthma,

infertility and cancer, it will also be of interest to health professionals, environmental

scientists and lawyers.

Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists (this predictive aspect is important due to the vast number of different potential chemical combinations – far too many to comprehensively catalog)A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures, for groups including chemists and engineers, toxicologists, health professionals and environmental scientistsNew and updated material comprises over 30% of this timely new edition, which includes the latest research data alongside an expanded introduction to the science and art of predicting the toxicological properties of chemical mixtures

PART I

1) Introduction to Chemical Toxicology of Mixtures

2) Health Effects of Exposures to Chemical Mixtures

3) Absorption of Chemical Mixtures

4) Chemical Toxicology

PART II Exposures to Chemical Mixtures

5) Scope and sources of toxic exposures

6) In Utero Exposure

7) Air Pollution

8) Water Pollution

9) Soil Pollution

10) Food

11) Chemicals In and Around The Home

12) Sick Building Syndrome

13) Industrial Exposure

14) Pesticides

15) Alcohol and Tobacco: Recreational Toxins

16) Electromagnetic Radiation and Toxic Exposure

PART III Mixture Effects on Body Systems

17) Respiratory System

18) Nervous System

19) Developmental Neurotoxicology

20) Autism: Effect of Maternal Exposure to Neurotoxic Chemcials

21) Attention Deficit Hyperactivity Disorder (ADHD)

22) Endocrine System

23) Toxic Infertility

24) Teratogens

25) Immune System

26) Chemical Sensitivity: Multiple Chemical Sensitivity (MCS)

27) Skin

28) Musculoskeletal System

29) Cardiovascular System

30) Liver

31) Kidneys

32) Cancer

33) Childhood Cancer

34) Cancer Clusters

PART IV Regulatory Requirements

35) Regulatory Requirements

36) Conclusions and Recommendations