Focal Therapy in Prostate Cancer

Do you manage patients with prostate cancer?

Are you keen on learning more about the very latest form of treatment?

Focal therapy represents a potentially huge shift in the way in which men with localized prostate cancer are treated. By targeting and treating only the cancer areas in the gland, it offers a credible alternative to more traditional radical surgery or active surveillance.

Focal Therapy in Prostate Cancer provides you with an evidence–based, dynamic and comprehensive review of this exciting new form of treatment, written by an outstanding international team of leading urologists, oncologists, radiologists and pathologists. Well–illustrated throughout, chapters are divided into key sections covering the key questions faced by cancer specialists and patients interested in focal therapy:

Is there a role for focal therapy in localized prostate cancer? How can we accurately locate cancer within the gland? How can we create discrete tissue necrosis? How can we determine the success of focal therapy?

No other book goes into such detail or covers the range of different technologies used for this cutting–edge therapy. With expert guidance throughout to help improve your clinical knowledge, Focal Therapy in Prostate Cancer is an essential guide for all training and practicing oncologists, urologists, and radiologists as well as the general physician with a keen interest in cancer care.

Titles of Related Interest

Challenges in Prostate Cancer, 2nd Edition
Bowsher, ISBN 9781405107525

Interventional Techniques in Uro–oncology>/i?
Ahmed, ISBN 9781405192729

Website: www.wiley.com/go/urology

Contributor List, vii

Preface, xi

Section I Is there a role for Focal Therapy in Localised Prostate Cancer?, 1

1 The Rationale for Focal Therapy of Prostate Cancer, 3
Cole Davis, Matthew Cooperberg, and Peter R. Carroll

2 Factors That Affect Patients′ Choice of Treatment, 11
Deb Feldman–Stewart and Michael D. Brundage

3 Histological Trends and the Index Lesion in Localized Prostate Cancer, 17
Vladimir Mouraviev, Thomas Wheeler, and Thomas J. Polascik

4 Selection Criteria for Prostate Cancer Focal Therapy, 29
Rajat K. Jain, Timothy K. Ito, and Samir S. Taneja

Section II How can we accurately locate cancer within the gland?, 37

5 Localisation of Cancer within the Gland: Biopsy Strategies, 39
Winston E Barzell and Rodrigo Pinochet

6 Localisation of Cancer within the Gland: Ultrasound Imaging, 47
Ulrich Scheipers

7 Localization of Cancer within the Prostate: Dynamic Contrast–Enhanced MRI, 55
Philippe Puech, Anwar Padhani, Laurent Lemaitre, Nacim Betrouni, Pierre Colin, and Arnauld Villers

8 Localization of Cancer within the Gland: Diffusion–Weighted Magnetic Resonance Imaging of the Prostate, 66
Sophie F Riches, Nina Tunariu, and Nandita M deSouza

9 The future of Molecular and Biomolecular Imaging in Prostate Cancer, 75
Michael S. Gee and Mukesh G. Harisinghani

Section III How can we create discrete tissue necrosis?, 85

10 Energies for Focal Ablation: Cryoablation, 87
John F. Ward

11 Focal Salvage Cryoablation in Recurrent Prostate Cancer, 98
Katsuto Shinohara

12 High–Intensity Focused Ultrasound, 106
Hashim Uddin Ahmed and Mark Emberton

13 Energies for Focal Ablation: Photodynamic Therapy, 114
Caroline M. Moore, Nimalan Arumainayagam and Mark Emberton

14 Focal Therapy for Prostate Cancer Using Radiation, 126
Irving Kaplan, Elizabeth Genega and Neil Rofsky

15 Image Registration and Fusion for Image–Guided Focal Ablation, 132
Dean Barratt and David Hawkes

Section IV How can we determine the success of Focal Therapy? , 143

16 Determining Success of Focal Therapy: Biochemical and Biopsy Strategies, 145
Al Barqawi, Paul Maroni, and David Crawford

17 Determining Success of Focal Therapy: Imaging, 153
Alex Kirkham and Clare Allen

18 Evaluating Focal Therapy: Future Perspectives, 170
Hashim Uddin Ahmed and Mark Emberton

Index, 179

Colour plate section can be found facing page 116

Edited by Hashim U. Ahmed, Division of Surgery and Interventional Science, University College London, London, UK

Manit Arya, Department of Urology, University College London, London, UK

Peter R. Carroll, Department of Urology, University of California, San Francisco, CA, USA

Mark Emberton, Division of Surgery and Interventional Science, University College London, London, UK

Whilst the book is not designed to represent a daily reference guide for the majority of the urological fraternity, it clearly does what it sets out to do; provide an up–to–date and comprehensive analysis of a treatment option that perhaps one day we will routinely consider alongside active surveillance and robotic surgery.   (Urology News, 1 November 2012)