Metal Complex – DNA Interactions

The importance of metal–DNA interactions in living systems, and their potential applications especially in the treatment and diagnosis of diseases has stimulated considerable recent interest in this area. The most important application is the antitumour action of certain heavy metals, which work by binding to and distorting DNA, causing cell death. For example, Cisplatin (Cl2H6N2Pt ) is one of the most potent and widely used anticancer drugs in use today.

This book provides an overview of metal–DNA interactions, the mechanism of their interaction, metal–based drugs and metal ion toxicity. It is essential reading for academic researchers in bioinorganic chemistry, biochemistry, biology, biotechnology and medicine, and pharmaceutical industries involved in developing metal–based drugs.

Spis treści:
A Basic Structural and Kinetic Aspects
1. Sequence–Selective Binding of Transition Metal Complexes to DNA
2. Thermodynamic Models of Metal Ion –DNA.Interactions
3. Metal Ion Coordination in G–quadruplexes
4. Supramolecular Chemistry of Metal–Nucleobase Complexes
B Medical Applications
5. Platinum Drugs, Nucleotides, and DNA: the Role of Interligand Interactions,
nucleotides and DNA
6. Role of DNA Repair in Antitumor Effects of Platinum Drugs
7. Telomeres and Telomerase: Potential Targets for Platinum Complexes
8. Toward Photodynamic Therapy of Cancer with Platinum Group Metal Polyazine Complexes
9. Platinated Oligonucleotides: Synthesis and Applications for the Control of Gene
Expression
10. New Titanium and Ruthenium Anticancer Drugs and their Interaction with DNA
C DNA–Recognition – Nucleases and Sensors
11. Groove–Binding Ruthenium(II) Complexes as Probes of DNA Recognition
12. DNA Recognition and Binding by Peptide–Metal Complex conjugate
13. Artificial Restriction Agents – Hydrolytic Agents for DNA Cleavage
14. New Metallo–DNAzymes: Fundamental Studies of Metal–DNA Interactions and
Metal Sensing Applications
15. Two–metal Ion Dependent Catalysis in Nucleic Acid Enzymes
D Toxicological aspects
16. Mercury– DNA Interactions. Structural Studies on MercuryII –Mediated T–T Base–Pair with NMR Spectroscopy
17. Chromium–Induced DNA Damage and Repair
18. Arsenic and nickel: Mechanisms Affecting DNA Integrity

Nota biograficzna:
Nikolaos Hadjiliadis is Professor in the Dept of Chemistry at the University of Ioannina, Greece. Einar Sletten is Professor in the Dept of Chemistry at the University of Bergen, Norway.

Okładka tylna:
The importance of metal–DNA interactions in living systems, and their potential applications especially in the treatment and diagnosis of diseases has stimulated considerable recent interest in this area. The most important application is the antitumour action of certain heavy metals, which work by binding to and distorting DNA, causing cell death. For example, Cisplatin (Cl2H6N2Pt ) is one of the most potent and widely used anticancer drugs in use today.

This book provides an overview of metal–DNA interactions, the mechanism of their interaction, metal–based drugs and metal ion toxicity. It is essential reading for academic researchers in bioinorganic chemistry, biochemistry, biology, biotechnology and medicine, and pharmaceutical industries involved in developing metal–based drugs.