The Handbook of Alzheimers Disease and Other Dementias

The book will provide the reader with a comprehensive review of Alzheimer’s disease and other Dementias from both basic and clinical neuroscience perspectives in a single volume. There is no volume that encompasses the specific range of topics to be presented in this volume. Other volumes on the market are focused more narrowly on either basic sciences or behavioral and clinical sciences. The combination of basic molecular perspectives and cognitive neurosciences is novel.
The book opens with an introduction and overview to the major dementias and expores pathology, manifestations, and treatment and other necessary background on the diseases such as Alzheimer′s, Pik′s Disease, and Vascular Dementia. Section Two explores the state of the art research on specific diseas mechanism relaevant to dementia such as neuropathology and epidemiology and genetic risk factors. Seciton Three examines most recent research on major topics in cognitive and behavioral neuroscience as it relates to Dementia. The final section of the book explores the state of the art research in neuroimaging relevant to Dementia.

Spis treści:
Contributors ix
Foreword xii
Preface xv
Part I Common Dementias 1
1 Alzheimer’s Disease 3
Alan M. Mandell and Robert C. Green
2 Vascular Dementia 92
Angela L. Jefferson, Amanda M. Gentile, and Ravi Kahlon
3 Dementia with Lewy Bodies 131
Tamara G. Fong and Daniel Z. Press
4 Frontotemporal Dementia 145
Adam L. Boxer
5 Other Dementias 179
Peter Morin
Part II Pathogenesis and Disease Mechanisms 195
6 Genetic Risk Factors for Dementia 197
Paul Hollingworth and Julie Williams
7 The Neuropathology of the Dementing Disorders 235
Ann C. McKee and Brandon E. Gavett
8 Amyloid Beta Peptide and the Amyloid Cascade Hypothesis 262
Carmela R. Abraham
9 Other Mechanisms of Neurod egeneration 277
Marina Boziki, Vassilis Papaliagkas, and Magda Tsolaki
10 Rational Therapeutics for Alzheimer’s Disease and Other Dementias 301
Neil W. Kowall
Part III Cognitive and Behavioral Dysfunction 313

11 Memory Dysfunction in Dementia 315
Andrew E. Budson
12 Language Processing in Dementia 336
Jamie Reilly, Joshua Troche, and Murray Grossman
13 Executive Functioning 369
Robert A. Stern, Stacy L. Andersen, and Brandon E. Gavett
14 Emotion and Behavior in Alzheimer’s Disease and Other Dementias 416
Christopher I. Wright
15 Visuospatial Function in Alzheimer’s Disease and Related Disorders 457
Alice Cronin–Golomb
16 Sleep and Circadian Rhythms in Dementia 483
David G. Harper
Part IV Neuroimaging in Dementia 505
17 Glimpses of the Living Brain with Alzheimer’s Disease 507
Ronald J. Killiany
18 Functional MRI in Alzheimer’s Disease and Other Dementias 535
Maija Pihlajamäki and Reisa A. Sperling
19 Molecular Neuroimaging of the Dementias 557
Bradford C. Dickerson
20 Using EEG and MEG to Understand Brain Physiology in Alzheimer’s Disease and Related Dementias 575
Brandon A. Ally
Index 604

Nota biograficzna:
Neil W. Kowall graduated with his MD from the University of British Columbia in 1979. He received postgraduate training in Internal Medicine at the Beth Israel Deaconess followed by a Neurology residency at Massachusetts General Hospital. After completion of his clinical training he completed a postdoctoral research fellowship and was appointed Assistant Professor of Neurology at Massachusetts General Hospital and Harvard Medical School . He moved to the Bedford VA Medical Center in 1992 where he is now Director of the New England Geriatrics Research Education and Clinical Center. He is a Professor of Neurol ogy and Pathology at Boston University School of Medicine and directs the NIH–funded Boston University Alzheimer’s Disease Center. His major research interests are human neuroanatomy and neuropathology and animal models of neurodegenerative disease. NIH, VA and private foundations support his research. He has published over 100 original peer–reviewed manuscripts. Dr. Kowall has received various awards, including the following: two Medical Research Council Studentship awards, the Russel Prize in Anatomy, the Hamber Prize in Medicine, the Bristol Medical Prize in Pharmacology, the Merck Scholarship in Medical Therapeutics, the Mead Prize in Pediatrics, the FIRST Award (R29) from National Institute of Neurological Disorders and Stroke, the Moore Award for Best Paper on Clinicopathological Correlation from the American Association of Neuropathologists, two Director′s Special Quality Awards/Commendations from the Bedford VAMC, and the Zenith Award from the Alzheimer′s Association.

Andrew E. Budson (MD from Harvard Medical School) is Associate Professor of Neurology at Boston University′s School of Medicine. He is also the Director of Cognitive Neuroscience Research at Boston University′s Alzheimer′s Center. He is a member of the Cognitive Neuroscience Society and American Academy of Neurology. He is on the editorial boards of several journals such as "Neuropsychology," "Cognitive Neuroscience," and "Neurobiology of Aging." He is a frequent invited speaker on Alzheimer′s and cognitive disorders. His research uses the techniques of experimental psychology and cognitive neuroscience to understand how memory breaks down in patients with Alzheimer’s disease.

Okładka tylna:
The book will provide the reader with a comprehensive review of Alzheimer’s disease and other Dementias from both basic and clinical neuroscience perspectives in a single volume. There is no volume that en compasses the specific range of topics to be presented in this volume. Other volumes on the market are focused more narrowly on either basic sciences or behavioral and clinical sciences. The combination of basic molecular perspectives and cognitive neurosciences is novel.
The book opens with an introduction and overview to the major dementias and expores pathology, manifestations, and treatment and other necessary background on the diseases such as Alzheimer′s, Pik′s Disease, and Vascular Dementia. Section Two explores the state of the art research on specific diseas mechanism relaevant to dementia such as neuropathology and epidemiology and genetic risk factors. Seciton Three examines most recent research on major topics in cognitive and behavioral neuroscience as it relates to Dementia. The final section of the book explores the state of the art research in neuroimaging relevant to Dementia.