Heterocyclic Chemistry

Heterocyclic chemistry is a central part of organic chemistry and biochemistry. The term refers to a particular set of chemical structure characteristics, with many drugs and specialty chemicals, and most agrochemicals, containing these characteristics. Heterocyclic Chemistry by Joule & Mills has established itself as the premier textbook of heterocyclic chemistry, used by high level undergraduates, postgraduates and industrial researchers all over the world.
Heterocyclic Chemistry covers the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second– and third–year undergraduate chemistry students. It also includes more advanced material, making the book appropriate for postgraduate taught courses and to researchers, either at postgraduate degree level or those working with heterocyclic compounds in industry. Essential teaching material is collected in specific introductory chapters, explaining the principles of heterocyclic reactivity in the simplest terms, suitable either as introductions or as summaries for examination preparation. These chapters are augmented by detailed, systematic discussions of the chemical reactivity of particular heterocyclic systems. References to both primary literature and reviews are given throughout the text, and whilst these are essential for postgraduate teaching and to research workers, they do not interfere with the readability of the text for undergraduate students.

Spis treści:
Preface
Definitions of abbreviations
1. Heterocyclic nomenclature
2. Structures and spectroscopic properties of aromatic heterocycles
3. Substitutions of aromatic heterocycles
4. Organometallic heterocyclic chemistry
5. Methods in heterocyclic chemistry
6. Ring synthesis of aromatic heterocycles
7. Typical reactivity of pyridines, quinolines and isoquinolines
8. Pyridines: reaction s and synthesis
9. Quinolines and isoquinolines: reactions and synthesis
10. Typical reactivity of pyrylium and benzopyrylium ions, pyrones and benzopyrones
11. Pyryliums, 2– and 4–pyrones: reactions and synthesis
12. Benzopyryliums, benzopyrones: reactions and synthesis
13. Typical reactivity of the diazines: pyridazine, pyrimidine and pyrazine
14. The diazines: pyridazine, pyrimidine, and pyrazine: reactions and synthesis
15. Typical reactivity of pyrroles, thiophenes, and furans
16. Pyrroles: reactions and synthesis
17. Thiophenes: reactions and synthesis
18. Furans: reactions and synthesis
19. Typical reactivity of indoles, benzo[b]thiophenes, benzo[b]furans, isoindoles, benzo[c]thiophenes and isobenzofurans
20. Indoles: reactions and synthesis
21. Benzo[b]thiophenes and benzo[b]furans: reactions and synthesis
22. Isoindoles, benzo[c]thiophenes and isobenzofurans: reactions and synthesis
23. Typical reactivity of 1,3– and 1,2–azoles and benzo–1,3– and –1,2–azoles
24. 1,3–Azoles: imidazoles, thiazoles, and oxazoles: reactions and synthesis
25. 1,2–Azoles: pyrazoles, isothiazoles, isoxazoles: reactions and synthesis
26. Benzanellated azoles: reactions and synthesis
27. Purines: reactions and synthesis
28. Heterocycles containing a ring–junction nitrogen (bridgehead compounds)
29. Heterocycles containing more than two heteroatoms
30. Saturated and partially unsaturated heterocyclic compounds: reactions and synthesis
31. Special topics
32. Heterocycles in biochemistry; heterocyclic natural products
33. Heterocycles in medicine


Nota biograficzna:
John Joule is Emeritus Professor in t he School of Chemistry, The University of Manchester, UK
Keith Mills spent 25 years in the Medicinal Chemistry and Development Chemistry departments at GlaxoSmithKline, Stevenage, UK, and is now an independent consultant.

Okładka tylna:
Heterocyclic chemistry is a central part of organic chemistry and biochemistry. The term refers to a particular set of chemical structure characteristics, with many drugs and specialty chemicals, and most agrochemicals, containing these characteristics. Heterocyclic Chemistry by Joule & Mills has established itself as the premier textbook of heterocyclic chemistry, used by high level undergraduates, postgraduates and industrial researchers all over the world.
Heterocyclic Chemistry covers the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second– and third–year undergraduate chemistry students. It also includes more advanced material, making the book appropriate for postgraduate taught courses and to researchers, either at postgraduate degree level or those working with heterocyclic compounds in industry. Essential teaching material is collected in specific introductory chapters, explaining the principles of heterocyclic reactivity in the simplest terms, suitable either as introductions or as summaries for examination preparation. These chapters are augmented by detailed, systematic discussions of the chemical reactivity of particular heterocyclic systems. References to both primary literature and reviews are given throughout the text, and whilst these are essential for postgraduate teaching and to research workers, they do not interfere with the readability of the text for undergraduate students.