Synthesis of Naturally Occurring Nitrogen Heterocycles from Carbohydrates

Carbohydrates are widely distributed in nature and easily available, so are considered as a promising feedstock for the preparation of many organic chemical compounds, and are particularly useful in the preparation of nitrogen heterocycles because of their related structural characteristics.
Synthesis of Naturally Occurring Nitrogen Heterocycles from Carbohydrates reviews the recent literature dealing with use of carbohydrates as raw materials in the synthesis of these materials. It provides a detailed discussion of the various synthetic approaches to these compounds, using carbohydrate starting materials, and attempts to give as much detail as possible on the actual experimental conditions used, in such a way that the chemist can use the information directly to design a multi–step synthesis. Written for organic chemists in the pharmaceutical, agrochemicals and specialty organic chemicals industries, and faculty and postgraduate students working on the synthesis of heterocyclic compounds, it discusses the different approaches to the synthesis of a wide range of naturally occurring nitrogen heterocycles in a format that enables the reader to make comparisons and decisions on whether to use a certain procedure, to modify it, or to devise a new synthetic methodology.

Spis treści:
Chapter 1 Five Membered Nitrogen Heterocycles.
1.1 Hydroxymethylpyrrolidines.
2–Hydroxymethyl–pyrrolidines.
Dihydro–2–hydroxymethylpyrrole (Nectrisine).
2,5–Dihydroxymethyl–pyrrolidines.
1.2 2–Carboxypyrrolidines.
Hydroxyprolines.
Bulgecins.
1.3 2–Aralkyl pyrrolidines.
Anisomycin.
Preussin.
1.4 2–Aryl pyrrolidines.
Codonopsinine and Codonopsine.
1.5 Miscellaneous.
Detoxins.
Gualamycin.
Lactacystin.
Chapter 2 Five Membered Heterocycles with two Heteroatoms.
2.1 Hydantocidin.
2.2 Bleomycin.
2.3 Calyculins.
2.4 Acivicin.
2.5 Bengazo le.
Chapter 3 Six Membered Nitrogen Heterocycles.
3.1 Hydroxymethylpiperidines.
Nojirimycin.
Mannojirimycin.
Galactonojirimycin.
Fagomine.
Homojirimycins.
3.2 Miscellaneous substituted piperidines.
2,6–Disubstituted–3–hydroxypiperidines.
Hydroxylated pipicolic acid.
Sesbanimide.
Siastatin.
Meroquinene.
Pyridyl of pyridomycin.
Chapter 4 Seven Membered Nitrogen Heterocycles.
4.1 Bengamides.
4.2 Liposidomycins.
Chapter 5 Fused Nitrogen Heterocycles.
5.1 3:5–Fused Heterocycles.
Azinomycins.
5.2 4:5–Fused Heterocycles.
b–Lactams.
5.3 5:5–Fused Heterocycles.
Polyhydroxypyrrolizidines.
Trehazolin.
Allosamidin.
Biotin.
5.4 5:6–Fused Heterocycles.
Hydroxylated indolizidines.
Castanospermine.
Swainsonine.
Lentiginosine.
Slaframine.
Miscellaneous.
Kifunensine.
Nagastatin.
Calystegines.
Mesembrine.
Streptolidine.
55 6:6–Fused Heterocycles.
Hydroxylated Quinuclidines.
Biopterins.
Isoquinolines.
Calycotomine.
Decumbenosine.
Laudanosine and glaucine.
Chapter 6 Multi–fused heterocycles.
6.1 Indoloquinolizidines.
Xylopinine.
Antirhine.
Allo–Yohimbane.
Ajmalicine.
6.2 Indolocarbazole Alkaloids.
6.3 Phenanthridone alkaloids.
6.4 Ecteinascidins

Nota biograficzna:
Professor El Sayed H. El Ashry1 Dr. Ahmed El Nemr 2
1 Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt.
2 Environmental Division, National Institute of Oceanography and Fisheries, Kayet Bay, Alexandria, Egypt.

Okładka tylna:
Carbohydrates are widely distributed in nature and easily available, so are considered as a promising feedstock for the preparation of many organic chemical compounds, and are particularly useful in the preparation of nitrogen heterocycles because of their related structural characteristics.
Synthesis of Naturally Occurring Nitrogen Heterocycles from Carbohydrates reviews the recent literature dealing with use of carbohydrates as raw materials in the synthesis of these materials. It provides a detailed discussion of the various synthetic approaches to these compounds, using carbohydrate starting materials, and attempts to give as much detail as possible on the actual experimental conditions used, in such a way that the chemist can use the information directly to design a multi–step synthesis. Written for organic chemists in the pharmaceutical, agrochemicals and specialty organic chemicals industries, and faculty and postgraduate students working on the synthesis of heterocyclic compounds, it discusses the different approaches to the synthesis of a wide range of naturally occurring nitrogen heterocycles in a format that enables the reader to make comparisons and decisions on whether to use a certain procedure, to modify it, or to devise a new synthetic methodology.