Fatty Liver Disease: NASH and Related Disorders

Fatty liver disease, especially non–alcoholic steatohepatitis (NASH), is emerging as the most common form of liver disease – affecting at least 5% of the population of western countries with increasing incidence in developing economies in other continents (particularly Asia, South America and South Africa).
NASH is the form of fatty liver disorder which can result in cirrhosis, particularly in those with diabetes or who are overweight, yet it is still not widely recognised despite its already high and increasing prevalence worldwide. This book explains what NASH is, why it happens, who gets it, how it can result in cirrhosis, when to think about it, how to select practical management between those with a minor abnormality from those who may have cirrhosis, and how to prevent and treat this ubiquitous condition.
Fatty Liver Diseases: NASH and Related Disorders is an unusual book: it combines a practical approach for students and physicians concerned with the problem with a clear overview on the causative mechanisms. It should appeal to doctors and other health care workers who encounter this problem, as well as to pathologists and investigators interested in the field of liver disease.

Spis treści:
Contributors.
Preface.
1 Overview: an introduction to NASH and related fatty liver disorders.
2 Pathology of hepatic steatosis, NASH and related conditions.
3 The epidemiology and risk factors of NASH.
4 Insulin resistance in NAFLD: potential mechanisms and therapies.
5 NASH as part of the metabolic (insulin resistance) syndrome.
6 NASH is a genetically determined disease.
7 The pathogenesis of NASH: human studies.
8 Animal models of steatohepatitis.
9 Fatty acid metabolism and lipotoxicity in the pathogenesis of NAFLD/NASH.
10 Cytokines and inflammatory recruitment in NASH: experimental and human studies.
11 Mitochondrial injury and NASH.
12 Cell biology of NASH: fibrosis and ce ll proliferation.
13 Clinical manifestations and diagnosis of NAFLD.
14 The clinical outcome of NAFLD including cryptogenic cirrhosis.
15 Practical approach to the diagnosis and management of people with fatty liver diseases.
16 Management of NASH: current and future perspectives on treatment.
17 NAFLD, NASH and orthotopic liver transplantation.
18 NAFLD/NASH is not just a ‘Western’ problem: some perspectives on NAFLD/NASH from the East.
19 NAFLD/NASH in children.
20 Steatohepatitis resulting from intestinal bypass.
21 Specific disorders associated with NAFLD.
22 Hepatocellular carcinoma in NAFLD.
23 Does NASH or NAFLD contribute to comorbidity of other liver diseases?.
24 Recent advances.
Index

Okładka tylna:
Fatty liver disease, especially non–alcoholic steatohepatitis (NASH), is emerging as the most common form of liver disease – affecting at least 5% of the population of western countries with increasing incidence in developing economies in other continents (particularly Asia, South America and South Africa).
NASH is the form of fatty liver disorder which can result in cirrhosis, particularly in those with diabetes or who are overweight, yet it is still not widely recognised despite its already high and increasing prevalence worldwide. This book explains what NASH is, why it happens, who gets it, how it can result in cirrhosis, when to think about it, how to select practical management between those with a minor abnormality from those who may have cirrhosis, and how to prevent and treat this ubiquitous condition.
Fatty Liver Diseases: NASH and Related Disorders is an unusual book: it combines a practical approach for students and physicians concerned with the problem with a clear overview on the causative mechanisms. It should appeal to doctors and other health care workers who encounter this problem, as well as to pathologists and investigators interested in the field of liver disease.