Osteoporosis: Diagnosis and Management

You can reduce the risk of your patients suffering an osteoporosis–related fracture. Osteoporosis is a highly prevalent, treatable disease, but it is currently incurable. Successful early diagnosis can lead to effective treatment strategies that reduce the risk of a patient’s life being compromised by serious fracture injury. In Osteoporosis , Dr Dale Stovall has assembled world–leading experts who guide you through modern best–practice approaches to: • Diagnosis of osteoporosis • Risk assessment for fractures • Use of calcium and vitamin D • Medical therapy and follow up • Future approaches to treatment Osteoporosis empowers you to identify and treat your patients with osteoporosis and low bone mass, preventing subsequent fractures and improving their quality of life.

List of Contributors, vii Preface, ix 1 Epidemiology and Genetics of Postmenopausal Osteoporosis, 1 Mark Edwards, Rebecca Moon, Nick Harvey & Cyrus Cooper 2 Osteoporosis in Men, 15 Robert A. Adler 3 Mechanisms of Bone Remodeling, 31 Maziar Shabestari & Erik Fink Eriksen 4 Fracture Risk Assessment, 46 Ronald C. Hamdy 5 Secondary Causes of Osteoporosis: Bone Diseases, 62 Peter R. Ebeling 6 Glucocorticoid–induced Osteoporosis, 79 Stuart Silverman & Swamy Venuturupalli 7 Secondary Causes of Osteoporosis: Other Medications, 93 Diane M. Biskobing 8 Hormone Therapy for Osteoporosis, 108 Pilar Valenzuela Mazo & James A. Simon 9 Bisphosphonates, 123 Paul D. Miller & Nelson B. Watts 10 Denosumab, 144 Michael A. Bolognese 11 Parathyroid Hormone: Anabolic Treatment of Osteoporosis, 158 Erik Fink Eriksen 12 Optimum Calcium and Vitamin D for the Prevention and Treatment of Osteoporosis, 178 Michael F. Holick 13 The Use of Combination Therapy in the Treatment of Postmenopausal Osteoporosis, 201 Juliet Compston 14 Emerging Therapies, 211 Michael R. McClung & Cristiano A. F. Zerbini 15 Monitoring Therapy for Osteoporosis, 227 E. Michael Lewiecki 16 Persistence and Compliance with Medications to Prevent Fractures: Epidemiology, Etiology, and Management Issues, 239 John T. Schousboe Appendix: A Clinician’s Approach to the Patient, 263 Robert Lindsay Index, 273

Edited by Dale W. Stovall , MD, Riverside Regional Medical Center, Newport News, VA, and University of Virginia Health System, Charlottesville, VA, USA