Hoffbrands Essential Haematology

The new and fully updated edition of the definitive haematology textbook for undergraduate and postgraduate students and trainees

Hoffbrand's Essential Haematology is widely regarded as the most authoritative introduction to the subject available, helping medical students and trainee doctors understand the essential principles of modern clinical and laboratory haematology for nearly four decades. Now in its eighth edition, this market-leading textbook introduces the formation and function of blood cells and the diseases that arise from dysfunction and disruption of these processes.

Beautifully presented with over 300 stunning colour illustrations, the new edition has been thoroughly updated to reflect recent advances in knowledge of the pathogenesis of blood diseases and their diagnosis and treatment. This new text:

Describes disorders and diseases of the blood such as the various anaemias and white cell disorders, leukaemias, lymphomas and myeloma, as well as bleeding and thrombotic disorders Incorporates the latest World Health Organization (WHO) classification of haematological neoplastic diseases Reviews contemporary application of multiparameter flow cytometry, DNA sequencing and other technologies in evaluating patients with suspected haematological disease Discusses the therapeutic use of chimeric antigen T-cells, mono- and bi-specific monoclonal antibodies, inhibitors of intracellular signalling pathways and direct orally acting anticoagulants Includes sections on blood transfusion and the haematological aspects of systemic diseases, pregnancy and the neonate

Hoffbrand's Essential Haematology is a vital resource for all students and trainees, and a valuable reference for practicing specialists wishing to update their knowledge.

Author Biography:

Victor Hoffbrand is Emeritus Professor of Haematology, University College London and Honorary Consultant Haematologist, the Royal Free Hospital London, UK.

David Steensma is Associate Professor of Medicine at Harvard Medical School, and Haematologist and Oncologist at Dana-Farber Cancer Institute, Boston, USA.

Preface to the Eighth Edition vi

Preface to the First Edition vii

How to use your textbook viii

About the companion website x

1 Haemopoiesis 1

2 Erythropoiesis and general aspects of anaemia 11

3 Hypochromic anaemias 27

4 Iron overload 42

5 Megaloblastic anaemias and other macrocytic anaemias 50

6 Haemolytic anaemias 64

7 Genetic disorders of haemoglobin 78

8 The white cells, part 1: granulocytes, monocytes and their benign disorders 96

9 The white cells, part 2: lymphocytes and their benign disorders 111

10 The spleen 126

11 The aetiology and genetics of haematological neoplasia 132

12 Management of haematological malignancy 147

13 Acute myeloid leukaemia 158

14 Chronic myeloid leukaemia 172

15 Myeloproliferative neoplasms 182

16 Myelodysplastic syndromes 196

17 Acute lymphoblastic leukaemia 206

18 The chronic lymphocytic leukaemias 219

19 Hodgkin lymphoma 229

20 Non-Hodgkin lymphomas 238

21 Multiple myeloma and related plasma cell neoplasms 255

22 Aplastic anaemia and bone marrow failure 272

23 Haemopoietic stem cell transplantation 281

24 Platelets, blood coagulation and haemostasis 296

25 Bleeding disorders caused by vascular and platelet abnormalities 312

26 Coagulation disorders 324

27 Thrombosis 1: pathogenesis and diagnosis 338

28 Thrombosis 2: treatment 347

29 Haematological changes in systemic diseases 360

30 Blood transfusion 372

31 Pregnancy and neonatal haematology 386

Appendix 395

Index 401