Practical Transfusion Medicine

The fifth edition of this practical textbook on transfusion medicine has been thoroughly revised with the latest in scientific and technological developments and edited by a leading team of international expert haematologists, including a new co–editor Mark H. Yazer MD.

The concise and comprehensive content covers the diverse field of transfusion medicine including; the fields of haemostasis, immunology, transplantation and cellular engineering; apheresis technology; treatment using recombinant and plasma–derived plasma proteins; and the daily use of blood components in clinical medicine. Such is the reach of the field that without transfusion resources ensuring the provision of a safe blood supply very little of modern surgery and medicine could be accomplished. The seven sections of this book guide the reader systematically through the key areas of the speciality; principles of transfusion medicine; complications of transfusion; practice in blood centres and hospitals; clinical transfusion practice; patient blood management; cellular and tissue therapy and organ transplantation; and development of the evidence base for transfusion.

This book offers:

A succinct and user–friendly resource with key points, charts and algorithms Discussion of practice in blood centres and hospitals, including regulatory aspects, transfusion safety, production and storage, donor care, and blood transfusion in a global context Coverage of cellular and tissue therapies and organ transplantation, including stem cell collection and haematopoietic stem cell processing and storage Review of the development of the evidence base for transfusion medicine Content on the alternatives to transfusions, and practical clinical advice

This book is ideal for trainee or resident haematologists revising for examinations and as a reference source for clinical and scientific staff working in the field of transfusion medicine.

1 Introduction: recent evolution of transfusion medicine
Walter H. (Sunny) Dzik and Mike Murphy

2 Essential immunology for transfusion medicine
Jaap Jan Zwaginga and S. Marieke van Ham

3 Human blood group systems
Geoff Daniels

4 Human leucocyte antigens
Cristina V. Navarrete and Colin J. Brown

5 Platelet and neutrophil antigens
Brian Curtis

6 Pretransfusion testing and selection of red cell products for transfusion
Mark Yazer and Meghan Delaney

7 Investigation of acute transfusion reactions
Kathryn E. Webert and Nancy M. Heddle

8 Haemolytic transfusion reactions
Edwin J. Massey, Robertson D. Davenport and Richard M. Kaufman

9 Febrile and allergic transfusion reactions
Mark K. Fung and Nancy M. Heddle

10 Acute lung injury after transfusion
Steven H. Kleinman and Daryl Kor

11 Purported adverse effects of old blood
Lirong Qu and Darrell Triulzi

12 Transfusion–related immunomodulation
Amy E. Schmidt, Majed A. Refaai, Joanna M. Heal and Neil Blumberg

13 Transfusion–associated graft–versus–host disease and microchimerism
Beth H. Shaz, Richard O. Francis and Christopher D. Hillyer

14 Posttransfusion purpura
Michael F. Murphy

15 Transfusion–transmitted infections
Roger Y. Dodd and Susan L. Stramer

16 Bacterial contamination
Sandra Ramirez–Arcoss and Mindy Goldman

17 Emerging infections and transfusion safety
Roger Y. Dodd

18 Regulatory aspects of blood transfusion
William G. Murphy, Louis M. Katz and Peter Flanagan

19 The role of haemovigilance in transfusion safety
Katharine A. Downes and Barbee Whittaker

20 Donors and blood collection
Marc Germain, Ellen McSweeney and William G. Murphy

21 Blood donation testing and the safety of the blood supply
Mindy Goldman

22 Production and storage of blood components
Marissa Li, Rebecca Cardigan, Stephen Thomas and Ralph Vassallo

23 Blood transfusion in hospitals
Erica M. Wood, Mark H. Yazer and Michael F. Murphy

24 Blood transfusion in a global context
David J. Roberts, Alan D. Kitchen, Stephen P. Field, Imelda Bates, Jean Pierre Allain and Meghan Delaney

25 Inherited and acquired coagulation disorders
Irina Chibisov and Frank Bontempo

26 Massive blood loss
John R. Hess

27 Blood management in acute haemorrhage and critical care
Gavin J. Murphy, Nicola Curry, Nishith Patel and Timothy S.Walsh

28 Point–of–care haemostasis testing
Lou Alarcon and Matthew Neal

29 Haematological disease
Lise J. Estcourt, Simon J. Stanworth and Michael F. Murphy

30 Blood transfusion in the management of patients with haemoglobinopathies
Enrico Novelli

31 Heparin–induced thrombocytopenia
Andreas Greinacher and Theodore E. Warkentin

32 Immunodeficiency and immunoglobulin therapy
Siraj A. Misbah

33 Fetal, neonatal and childhood transfusions
Ron Strauss

34 Principles of patient blood management
Jon Waters

35 Principles of Perioperative anaemia management
Toby Richards

36 Principles of Perioperative anaemia management
Tim Goodnough

37 Using data to support patient blood management
Steven M. Frank and Jack O. Wasey

38 Regulation and accreditation in cellular therapy
Zbigniew Ziggy M. Szczepiorkowski1 and Daniel Hollyman

39 Stem cell collection and therapeutic apheresis
Khaled El–Ghariani1 and Zbigniew M. Szczepiorkowski

40 Haemopoietic stem cell processing and storage
Ronan Foley and Pamela O Hoski

41 Haemopoietic stem cell transplantation
Robert D Danby, Rachel Protheroe and David J. Roberts

42 Cord blood transplantation
Rachael Hough and Robert Danby

43 Recent advances in clinical cellular immunotherapy
Mark W. Lowdell and Emma Morris

44 Tissue banking
Akila Chandrasekar, Paul Rooney and John Kearney

45 Observational and interventional trials in transfusion medicine
Alan Tinmouth, Dean Fergusson and Paul C. Hébert

46 Getting the most out of the evidence for transfusion medicine
Simon J. Stanworth, Susan J. Brunskill, Carolyn Dorée and Sally Hopewell

47 Primer in biostatistics
Andrew W Shih and Nancy M Heddle

48 Primer in health economics
Seemer Kacker and Aaron Tobian

49 Scanning the future of transfusion medicine
Jay Menitove, Paul Ness and Eric Snyder

MICHAEL F. MURPHY, Professor of Blood Transfusion Medicine, University of Oxford, UK

DAVID J. ROBERTS, Professor of Haematology, University of Oxford, UK

MARK H. YAZER, Professor of Pathology, University of Pittsburgh, USA; Adjunct Professor of Clinical Immunology, University of Southern Denmark, Denmark