Nutrigenomics and Proteomics in Health and Disease: Towards a Systems–level Understanding of Gene–diet Interactions

Now in a revised second edition, Nutrigenomics and Proteomics in Health and Disease brings together the very latest science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals and their impact on gene interaction and health. Authored by an international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date.

Thoroughly updated to reflect the most current developments in the field, the second edition includes six new chapters covering gut health and the personal microbiome; gut microbe–derived bioactive metabolites; proteomics and peptidomics in nutrition; gene selection for nutrigenomic studies; gene–nutrient network analysis; and nutrigenomics to nutritional systems biology. An additional five chapters have also been significantly remodelled. The new text includes a rethinking of in vitro and in vivo models with regard to their translatability into human phenotypes, and normative science methods and approaches have been complemented by more comprehensive systems biology–based investigations, deploying a multitude of omic platforms in an integrated fashion. Innovative tools and methods for statistical treatment and biological network analysis are also now included.

List of Contributors

Preface

SECTION I GENES, PROTEINS AND NUTRITION

1. Personalized Nutrition
Lydia Afman

2. Genetic–Epigenetic Interactions
Rima Rozen

3. Epigenetics and Metabolic Programming
Keith Godfrey and Peter Gluckman

SECTION II BIOACTIVES AND PHYTONUTRIENTS

4. Bioactive Interactions in Food and Natural Extracts
Sofia Moço and Denis Barron

5. Bioflavonoids and Biomarkers of Metabolic Syndrome
Mary Ann Lila and David H. Murdock

6. Dietary Antioxidants and Bioflavonoids in Atherogenesis and Angiogenesis
Mohsen Meydani, Angelo Azzi and Taiki Miyazawa

7. Proteomic and Genomic Approaches to Identify Sensitive Resveratrol Targets
César López–Camarillo

8. Genomic Effects of Food Bioactives in Neuroprotection
Ashraf Virmani

9. Food–based RNAs and their Bioactivity
Kendal Hirschi and Lisa Farmer

SECTION III PREBIOTICS, PROBIOTICS, SYNBIOTICS AND THE GUT ECOSYSTEM

10. Gut Health and the Personal Microbiome
Willem de Vos

11. Infant Nutrition and the Microbiome: Systems Biology Approaches to Host–Microbe Interactions
Mei Wang and Sharon M. Donovan

12. Gut Microbe–Derived Bioactive Metabolites
François–Pierre Martin

SECTION IV NUTRIGENOMIC AND PROTEOMIC TECHNOLOGIES

13. Network Analysis in Systems Nutrition
Corrado Priami and Marie–Pier Scott–Boyer

14. Gene Selection for Nutrigenomic Studies
Damien Valour

Index

About the Editors

Martin Kussmann is Professor of "Systems Biology in Nutrition and Health" at the Liggins Institute, University of Auckland, New Zealand. He is also Chief Scientist of New Zealand′s National Science Challenge "High–Value Nutrition". In 2011, Martin joined the Nestlè Institute of Health Sciences (NIHS) on the campus of the Ecole Polytechnique Fèdèrale Lausanne (EPFL), Switzerland, as Head of the "Molecular Biomarkers Core". From 2012 to 2016, he has been Lecturer at the Faculty of Life Sciences, EPFL. Since June 2009, Martin is Honorary Professor for Nutritional Science at the Faculty of Science, Aarhus University, Denmark. He holds a MSc and PhD in Chemistry from the University of Konstanz, Germany.

Patrick J. Stover is Professor and Director of the Division of Nutritional Sciences at Cornell University. He graduated from Saint Joseph′s University with a BS degree in Chemistry, and received a PhD degree in Biochemistry and Molecular Biophysics from the Medical College of Virginia, and performed his postdoctoral studies in Nutritional Sciences at the University of California at Berkeley.