Molecular and Biochemical Toxicology

An essential resource for students, academic, and industrial toxicologists and environmental health scientists

Throughout its past editions, this text has been an important source for defining the biochemical, cellular, and molecular events that toxicants induce at the cellular and organismic levels  and linking molecular and cellular biology as well as genomic sciences to mechanistic toxicology.

Though stemming from the editors course at North Carolina State and written as an advanced text for toxicology students, Molecular and Biochemical Toxicology is much more than an introduction and provides in–depth information describing the underlying mechanisms through which toxicants produce their adverse responses. Toxicologic issues are covered from both an organ–based approach along with the basic principles of toxicology and methodology.

While toxicology is a broad and comprehensive science, it is also true that different areas progress at different rates and molecular and mechanistic approaches have seen dramatic advances since the 4th edition of this text published. Changes in the new edition stress these advances in molecular techniques and their contributions to fundamental mechanisms of toxic action.

At the same time, the 5th edition provides continuity with advances in organ toxicity and develops ideas as to future applications. Additional features include:

Linkage of traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies
A didactic approach with basic biological or theoretical background for the methodology presented
Assembling and comprehensively covering a range of dynamic aspects in biochemical and molecular toxicology
Guidance for student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts

Whether used in the classroom or in industry, research or academia, Molecular and Biochemical Toxicology remains essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects.

Robert C. Smart, PhD, is the William Neal Reynolds Professor of Toxicology, Director of Graduate Programs, and Director of the Center for Human Health and the Environment at North Carolina State University. Together with Dr. Hodgson, he coedited the two previous editions of this book.

Ernest Hodgson, PhD, is Distinguished Professor Emeritus of Environmental and Molecular Toxicology and Executive Director of the Foundation for Toxicology and Agromedicine at North Carolina State University. Alongside the previous editions of this book, he edited four editions of A Textbook of Modern Toxicology (Wiley) and is the Editor of the Journal of Biochemical and Molecular Toxicology.