Rossis Principles of Transfusion Medicine

Transfusion medicine as a multidisciplinary clinical specialty allied to blood banking continues to be a dynamic and increasingly complex evolution. Patients who require blood transfusions generally fall into two categories: those requiring transfusions resulting from acute blood loss that might be associated with surgery or accident; or those requiring chronic transfusions associated with treatment for chronic anaemias, chemotherapy, or bone marrow transplant. As such transfusion medicine impacts all areas of critical care medicine, and multiple areas of chronic care.

Rossi′s Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available. Now updated for a fifth edition with new material on donor care including the frequency of donation and management of iron deficiency/status, patient blood management, hemovigilance, and the novel cellular therapies and stem cell transplantation. This is a key resource for specialists and trainees in transfusion medicine and blood banking, as well as physicians, nurses, and medical technologists active in the transfusion of patients.

This edition;

Compiled by a world class Editor team including two past–presidents of AABB, a past– President of the American Board of Pathology and members of the FDA Blood Products Advisory Committee, and international contributor team Covers current hot topics such as donor care including the frequency of donation and management of iron deficiency/status), patient blood management, hemovigilance, and the organization of transfusion and transplant services Presents new material on molecular immunohematology Companion website includes figures, full text and references Update your practice with this comprehensive reference resource, considered the gold standard in transfusion medicine.

1 Transfusion in the New Millennium

Ennio C. Rossi, Toby L. Simon

Section I. Contemporary Issues in Donation and Transfusion

2 Patient Blood Management

Darrell J. Triulzi, Mark H. Yazer, J.H. Waters

3 Clinical and Technical Aspects of Blood Administration

Eric Gehrie, Jocelyn Chandler, Edward Snyder

4 Recruitment and Screening of Donors and the Collection, Processing, and Testing of Blood

Kendall P. Crookston, Aaron E. Pritchard, Toby L. Simon

5 Adverse Reactions and Iron Deficiency after Blood Donation

Anne F. Eder, Joseph E. Kiss

6 Donor Vigilance and Hemovigilance

Øystein Flesland, Johannna C. Wiersum–Osselton

7 Global Perspective on Ensuring Blood and Blood Product Safety and Availability

Paul D. Mintz, Mark J. Weinstein

Section II. Blood Components and Derivatives

Part I. Red Blood cells

8 Red Blood Cell Production and Kinetics

Mark J. Koury

9 Red Blood Cell Metabolism, Preservation and Oxygen Delivery

John R. Hess, Bjarte G. Solheim

10 Anemia and Red Blood Cell Transfusion

Jeffrey L. Carson, Paul Hébert

11 Sickle Cell Anemia, Thalassemia and Congenital Hemolytic Anemias

Keith Quirolo, Elliott Vichinsky

12 Autoimmune Hemolytic Anemias and Paroxysmal Nocturnal Hemoglobinuria

Andrea M. McGonigle, Paul M. Ness, Karen E. King

13 Carbohydrate Blood Groups

Laura Cooling

14 Rh and LW Blood Groups

Connie M. Westhoff, Don L. Siegel

15 Other Protein Blood Groups

Jill R. Storry

16 Red Cell Immunology and Compatibility Testing

Connie M. Westhoff

Part II: Platelets

17 Platelet Production and Kinetics

Christopher A. Tormey, Henry M. Rinder

18 Platelet Immunology and Alloimmunization

Janice G. McFarland

19 Preparation, Preservation, and Storage of Platelet Concentrates

Ralph R. Vassallo, Jr.

20 Thrombocytopenia and Platelet Transfusion

Mike F. Murphy, Simon Stanworth, Lise Estcourt

21 Management of Immune–Mediated Thrombocytopenia

Donald M. Arnold, Ishac Nazi, James W. Smith, Theodore E. Warkentin

Part III: White Blood Cells

22  Neutrophil Production and Kinetics: Neutropenia and Neutrophilia

Lawrence Rice and Miho Teruya

23 Neutrophil Collection and Transfusion

Ronald G. Strauss

24 Leukocyte–Reduced Blood Components: Laboratory and Clinical Aspects

Tor Hervig, Jerard Segatchian

Part IV Plasma

25 Composition of Plasma

Peter Hellstern

26 Plasma and Cryoprecipitate for Transfusion

Simon J. Stanworth, Alan T. Tinmouth

27 The Purification of Plasma Proteins for Therapeutic Use

Joseph Bertolini

28 Recombinant Products for the Treatment of Hemophilia: Recent Advances

Michael Wilson, Andrew Nash, Iris Jacobs, Arna Andrews

29 Coagulation Factor Concentrates for Inherited Bleeding Disorders

Gary M. Woods, Amy L. Dunn

30 Coagulation Factor Concentrates and Pharmacologic Therapies for Acquired Bleeding Disorders

Neil Shah, Lawrence Tim Goodnough

31  Immunoglobulin Products

Melvin Berger

Section III: Apheresis, Transplantation, and New Therapies

32 Apheresis: Principles and Technology of Hemapheresis

Edwin A. Burgstaler, Jeffrey L. Winters

33 Therapeutic Apheresis

Bruce McLeod, Shanna Morgan, Jeffrey McCullough

34 Therapeutic Phlebotomy and Specialized Hemapheresis

Jeffrey A. Bailey, Robert Weinstein

35 Hematopoietic Growth Factors

David J. Kuter

36 Hematopoietic Stem Cells and Cord Blood

Jeffrey McCullough

37 Hematopoietic Stem Cell Transplantation

Sameh Gaballa, Amin Alousi, Sergio Giralt, Richard Champlin

38 Gene Therapy Applications to Transfusion Medicine

Eric A. Gehrie, Alexey Bersenev, Emanuela Bruscia, Diane Krause, Wade Schulz

39 HLA Antigens and Alleles

Christian Naper, Bjarte G. Solheim

40 Tissue Banking

Ralph M. Powers, Jeanne V. Linden

41 Adoptive Immunotherapy

Sarah M. Drawz, Jeffrey S. Miller, David H. McKenna

42 Tissue Engineering and Regenerative Medicine

Sumati Sundaram, Joshua Siewert, Jenna Balestrini, Ashley Gard, Kevin Boehm, Elise Wilcox, Laura Niklason

Section IV. Specialized Clinical Practice

Part I: Obstetrics and Pediatrics

43 Obstetric Transfusion Practice

Marieke B.Veenhof, Jos J.M. van Roosmalen, Anneke Brand

44 Fetal and Neonatal Hematopoiesis

Robert D. Christensen, Martha C. Sola–Visner

45 Hemolytic Disease of the Fetus and Newborn

Bjarte G. Solheim, Morten Grönn, Thor Willy Ruud Hansen

46 Red Blood Cell Transfusions for Neonates and Infants

Ronald G. Strauss

47 Platelet and Plasma Transfusions for Infants and Children

Jeanne E. Hendrickson, Cassandra D. Josephson

Part II: Surgery and Trauma

48 Perioperative Transfusion Needs

Leanne Clifford, Daryl J. Kor, James R. Stubbs

49 Transfusion Therapy in the Care of Trauma and Burn Patients

John R. Hess, John B. Holcomb, Steven E. Wolf, Michael W. Cripps

Part III: Oncology

50 Transfusion Support for the Oncology Patient

Wade L. Schulz, Edward L. Snyder

Section V. Hazards of Transfusion

Part I: Infectious Hazards

51 Transfusion Transmitted Virus Infections (TTVI)

Erhard Seifried, Michael Schmidt

52 Transfusion Transmission of Parasites

Bryan R. Spencer

53 Bacterial Contamination of Blood Components

Richard J. Benjamin

54 Prion Diseases

Marc L. Turner

55 Testing for Pathogens in Donors

Tho D. Pham, Susan A. Galel

56 Pathogen Reduction of Blood Components and Plasma Derivatives

Nathan J. Roth

Part II: Other Hazards

57 Hemolytic Transfusion Reactions

Robertson D. Davenport, Martin H. Bluth

58 Febrile, Allergic, and Non–immune Transfusion Reactions

Emmanuel Fadeyi, Gregory J. Pomper

59 Transfusion–Related Lung Injury

Ulrich J. Sachs, Jonathan P. Wallis

60 Transfusion–Associated Graft Versus Host Disease

Eric Gehrie, Edward Snyder, Alex Ryder

61 Transfusional Iron Overload

Sujit Sheth

62  Immunomodulatory and Pro–Inlammatory Effects of Allogeneic Blood Transfusion

Eleftherios C. Vamvakas, José O. Bordin, Morris A. Blajchman

Dr. Toby Simon is senior medical director at CSL Behring, a biotherapeutics company that is a world leader in fractionation of plasma for blood derivatives. He has previous experience in both blood centers and transfusion services and did research in transfusion medicine for many years at the University of New Mexico School of Medicine and has most recently been a consultant to the NIH REDS II program. He is a past president of AABB and America s Blood Centers. He served on the American Board of Pathology Transfusion Medicine Test Development and Advisory Committee for over 25 years and is currently in his second term as Inudstry Representative on the FDA Blood Products Advisory Committee.

Dr. Jeffery McCullough is professor of laboratory medicine and pathology at the University Of Minnesota School Of Medicine where he has been since 1978 including service as Medical Director of the hospital blood bank.. He directed the entire American Red Cross Blood Program in the past and has also served as President of the American Board of Pathology and several terms as editor of Transfusion. He has directed national research programs and published extensively including a single authored book in Transfusion Medicine published by Wiley.

Dr. Edward Snyder is professor of laboratory medicine at Yale University School of Medicine. He also serves as associate chair of his department for clinical affairs and director of apheresis/transfusion service and blood bank. He was an editor of the third and fourth editions of this text. He is a past–president of AABB. He has published extensively and is currently an investigator in the NIH REDS III project.

Dr. Bjarte Solheim is Professor Emeritus at the Institute of Immunology at Rikshospitalet University Hospital and University of Oslo School of Medicine in Oslo, Norway. He was an editor of the fourth edition and was instrumental in making this text an international one by recruiting many European authors. While officially retired, he remains active in clinical and research aspects of transfusion medicine.

Dr. Ronald Strauss is Professor Emeritus of Pathology and Pediatrics at the University Of Iowa School Of Medicine. Since his retirement from Iowa he has remained active in transfusion medicine research and has also been serving as associate medical director of LifeSource/Institute of Transfusion Medicine in Chicago. He serves on the American Board of Pathology Transfusion Medicine Test Development and Advisory Committee. He has a long research career with several NIH grants and roles in national research studies. He was an editor of the third and fourth editions.